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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi

Author(s): Xiliang Yang*, Jinping Liu, Jiahui Mei , Rui Jiang, Shizheng Tu, Huafeng Deng, Jing Liu, Sumei Yang and Juan Li*

Volume 21, Issue 15, 2021

Published on: 17 February, 2021

Page: [2000 - 2019] Pages: 20

DOI: 10.2174/1389557521666210217093517

Price: $65

Abstract

In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine- derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

Keywords: Penicillium, secondary metabolite, marine fungus, antimicrobial, cytotoxicity, enzymatic activity.

Graphical Abstract


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