Abstract
Quinone methides (QMs) are naturally occurring reactive intermediates which play important roles in organic syntheses as well as in a large number of chemical andbiological processes. QMs are also believed to be responsible for the ultimate cytotoxicity of many antitumor drugs, antibiotics, and DNA alkylators through enzyme inhibition or DNA alkylation. Many different chemical methods have been developed to synthesize QMs and their derivatives. This review highlights generation of QMs by exploiting cellular process and their biological applications.
Keywords: Quinone methides, in vivo generation, enzymatic oxidation, phenols, enzymatic reduction, quinones, ROS induction, arylboronates and arylboronic acids.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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