Phosphonomethoxyalkyl Analogs of Nucleotides

Title: Phosphonomethoxyalkyl Analogs of Nucleotides

Volume: 9 Issue: 31

Author(s): Antonin Holy

Affiliation:

Keywords: adefovir, cidofovir, tenofovir, aids, hepatitis b, dna viruses, retroviruses

Abstract: Acyclic nucleoside phosphonates (ANP) are analogs of nucleotides exhibiting various biological (e.g. antiviral, cytostatic, antiparasitic, immunomodulatory) activities. This review describes synthetic approaches to their preparation, biological activities, structure-activity relationships and mode of action of ANPs, with emphasis to selected drugs or drug candidates. Three compounds of the ANP group (cidofovir, adefovir, tenofovir) are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses.

Cite this article as:

Holy Antonin, Phosphonomethoxyalkyl Analogs of Nucleotides, Current Pharmaceutical Design 2003; 9 (31) . https://dx.doi.org/10.2174/1381612033453668