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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Phosphonomethoxyalkyl Analogs of Nucleotides

Author(s): Antonin Holy

Volume 9, Issue 31, 2003

Page: [2567 - 2592] Pages: 26

DOI: 10.2174/1381612033453668

Price: $65

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Abstract

Acyclic nucleoside phosphonates (ANP) are analogs of nucleotides exhibiting various biological (e.g. antiviral, cytostatic, antiparasitic, immunomodulatory) activities. This review describes synthetic approaches to their preparation, biological activities, structure-activity relationships and mode of action of ANPs, with emphasis to selected drugs or drug candidates. Three compounds of the ANP group (cidofovir, adefovir, tenofovir) are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses.

Keywords: adefovir, cidofovir, tenofovir, aids, hepatitis b, dna viruses, retroviruses


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