Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid

Title:Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid

Volume: 27 Issue: 22

Author(s): Rabia Batool, Azhar Rasul*, Ghulam Hussain, Muhammad Ajmal Shah*, Bushra Nageen, Iqra Sarfraz, Muhammad Kashif Zahoor, Ammara Riaz, Aiza Ajaz and Şevki Adem

Affiliation:

• Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000,Pakistan

• Department of Pharmacognosy, Faculty of Life Sciences, Government College University Faisalabad, 38000,Pakistan

Keywords: Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.

Abstract: Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.

Cite this article as:

Batool Rabia, Rasul Azhar *, Hussain Ghulam , Shah Ajmal Muhammad *, Nageen Bushra, Sarfraz Iqra , Zahoor Kashif Muhammad, Riaz Ammara , Ajaz Aiza and Adem Şevki, Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid, Current Pharmaceutical Design 2021; 27 (22) . https://dx.doi.org/10.2174/1381612827666210211125304