Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease

Title:Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease

Volume: 27 Issue: 22

Author(s): Md. Tanvir Kabir, Md. Sahab Uddin*, Sonia Zaman, Md. Sohanur Rahman, Tapan Behl, Ausaf Ahmad, Abdul Hafeez, Asma Perveen and Ghulam Md. Ashraf*

Affiliation:

• Department of Pharmacy, Southeast University, Dhaka,Bangladesh

• Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah,Saudi Arabia

Keywords: Anti-Neuroinflammatory effects, Alzheimer's disease, phytochemicals, steroids, terpenoids, neurodegeneration.

Abstract: Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that significantly affects cognitive functions in a way that causes loss of memory, thinking, and behavior. Multiple studies revealed that neuroinflammation associated with AD is linked with the amyloid-beta deposition in the brain. Elevated levels of expression of cytokines, microglial activation, nuclear factor kappa B, and reactive oxygen species play roles in AD-related inflammatory processes. Indeed, effective therapeutic approaches are urgently required to develop therapeutic agents to prevent and treat AD. So far, many anti-AD drug candidates have failed in the clinical stages and currently available drugs only provide symptomatic treatment. In recent times, pharmacologically active phytochemicals have been found to possess promising anti-neuroinflammatory effects; therefore, these natural products can be useful in AD treatment. In this review, we have comprehensively discussed the role of neuroinflammation and the molecular processes altered by multiple steroid and terpenoid-derived phytochemicals in various AD-related neuroinflammatory pathways. Indeed, steroid and terpenoid-derived phytochemicals show important therapeutic activities, which can be useful in ameliorating and treating AD-related neurodegeneration.

Cite this article as:

Kabir Tanvir Md. , Uddin Sahab Md. *, Zaman Sonia , Rahman Sohanur Md. , Behl Tapan, Ahmad Ausaf , Hafeez Abdul , Perveen Asma and Ashraf Md. Ghulam *, Exploring the Anti-Neuroinflammatory Potential of Steroid and Terpenoid-Derived Phytochemicals to Combat Alzheimer's Disease, Current Pharmaceutical Design 2021; 27 (22) . https://dx.doi.org/10.2174/1381612826666210101152352