Abstract
Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.
Keywords: Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.
Current Pharmaceutical Design
Title:Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid
Volume: 27 Issue: 22
Author(s): Rabia Batool, Azhar Rasul*, Ghulam Hussain, Muhammad Ajmal Shah*, Bushra Nageen, Iqra Sarfraz, Muhammad Kashif Zahoor, Ammara Riaz, Aiza Ajaz and Şevki Adem
Affiliation:
- Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000,Pakistan
- Department of Pharmacognosy, Faculty of Life Sciences, Government College University Faisalabad, 38000,Pakistan
Keywords: Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.
Abstract: Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.
Export Options
About this article
Cite this article as:
Batool Rabia, Rasul Azhar *, Hussain Ghulam , Shah Ajmal Muhammad *, Nageen Bushra, Sarfraz Iqra , Zahoor Kashif Muhammad, Riaz Ammara , Ajaz Aiza and Adem Şevki, Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid, Current Pharmaceutical Design 2021; 27 (22) . https://dx.doi.org/10.2174/1381612827666210211125304
DOI https://dx.doi.org/10.2174/1381612827666210211125304 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Graphical Abstracts
Letters in Drug Design & Discovery NAD<sup>+</sup>-Dependent Enzymes at the Endoplasmic Reticulum
Current Topics in Medicinal Chemistry Targeting Invasion Induction as a Therapeutic Strategy for the Treatment of Cancer
Current Cancer Drug Targets Nano-Delivery in Pediatric Tumors: Looking Back, Moving Forward
Anti-Cancer Agents in Medicinal Chemistry Quinazolines as Apoptosis Inducers and Inhibitors: A Review of Patent Literature
Recent Patents on Anti-Cancer Drug Discovery Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and their Application in Drug Discovery
Current Medicinal Chemistry CNS Drug Development – Lost in Translation?
Mini-Reviews in Medicinal Chemistry Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference <i>In Vitro</i> and <i>In Vivo</i>
Current Pharmaceutical Design Antiproliferative and Antifungal Activities of 1,3-diarylpropane-1,3-diones Commonly used as Sunscreen Agents
Letters in Drug Design & Discovery Epidemiology and Pathophysiology of Chronic Cough
Current Respiratory Medicine Reviews Targeting Angiogenesis for Treatment of NSCLC Brain Metastases
Current Cancer Drug Targets A Review of Aberrant DNA Methylation and Epigenetic Agents Targeting DNA Methyltransferases in Endometriosis
Current Drug Targets Targeting Cancer Stem Cells with Natural Products
Current Drug Targets Perspective of MiRNAs in Clinical Glioblastoma Research
Current Signal Transduction Therapy Polymeric Micelles of Modified Chitosan Block Copolymer as Nanocarrier for Delivery of Paclitaxel
Current Nanomedicine Crizotinib Versus Chemotherapy on ALK-positive NSCLC: A Systematic Review of Efficacy and Safety
Current Cancer Drug Targets The Significance of Ubiquitin Proteasome Pathway in Cancer Development
Recent Patents on Anti-Cancer Drug Discovery Bone: A Fertile Soil for Cancer Metastasis
Current Drug Targets Aptamers: Molecular Tools for Medical Diagnosis
Current Topics in Medicinal Chemistry β-Galactosylated Alkyl-oligoamine Derivatives of Polyethylenimine Enhanced pDNA Delivery into Hepatic Cells with Reduced Toxicity
Current Nanoscience