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Protein & Peptide Letters

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Mini-Review Article

Evolution and Structure of API5 and Its Roles in Anti-Apoptosis

Author(s): Meishan Chen, Weiwei Wu, Dongwu Liu, Yanhua Lv, Hongkuan Deng, Sijia Gao, Yaqi Gu, Mujie Huang, Xiao Guo, Baohua Liu, Bosheng Zhao and Qiuxiang Pang*

Volume 28, Issue 6, 2021

Published on: 11 December, 2020

Page: [612 - 622] Pages: 11

DOI: 10.2174/0929866527999201211195551

Price: $65

Abstract

Apoptosis, also named programmed cell death, is a highly conserved physiological mechanism. Apoptosis plays crucial roles in many life processes, such as tissue development, organ formation, homeostasis maintenance, resistance against external aggression, and immune responses. Apoptosis is regulated by many genes, among which Apoptosis Inhibitor-5 (API5) is an effective inhibitor, though the structure of API5 is completely different from the other known Inhibitors of Apoptosis Proteins (IAPs). Due to its high expression in many types of tumors, API5 has received extensive attention, and may be an effective target for cancer treatment. In order to comprehensively and systematically understand the biological roles of API5, we summarized the evolution and structure of API5 and its roles in anti-apoptosis in this review.

Keywords: Apoptosis, API5, anti-apoptosis, evolution, structure, functional pathways.

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