Abstract
The first study on fatty acid composition of the postmortem brains of patients with psychiatric disorders was performed by Horrobin et al. in 1991, who found abnormalities in polyunsaturated fatty acids (PUFAs) in patients with schizophrenia. About a decade later, research in this field was re-started by Yao et al., followed by a number of other research groups. The results seem to show that the PUFA changes in psychiatric disorders may be specific to certain brain regions, but the underlying mechanisms remain unclear. Here we review these case-control studies of postmortem brain composition.
Keywords: polyunsaturated fatty acids, case-control study, schizophrenia, bipolar disorder, major depressive disorder, postmortem brain
Current Psychopharmacology
Title:Polyunsaturated Fatty Acids and their Related Enzymes in Postmortem Brain Tissues of Patients with Psychiatric Disorders
Volume: 2
Author(s): Kei Hamazaki, Tomohito Hamazaki and Hidekuni Inadera
Affiliation:
Keywords: polyunsaturated fatty acids, case-control study, schizophrenia, bipolar disorder, major depressive disorder, postmortem brain
Abstract: The first study on fatty acid composition of the postmortem brains of patients with psychiatric disorders was performed by Horrobin et al. in 1991, who found abnormalities in polyunsaturated fatty acids (PUFAs) in patients with schizophrenia. About a decade later, research in this field was re-started by Yao et al., followed by a number of other research groups. The results seem to show that the PUFA changes in psychiatric disorders may be specific to certain brain regions, but the underlying mechanisms remain unclear. Here we review these case-control studies of postmortem brain composition.
Export Options
About this article
Cite this article as:
Hamazaki Kei, Hamazaki Tomohito and Inadera Hidekuni, Polyunsaturated Fatty Acids and their Related Enzymes in Postmortem Brain Tissues of Patients with Psychiatric Disorders, Current Psychopharmacology 2013; 2 (1) . https://dx.doi.org/10.2174/2211556011302010066
DOI https://dx.doi.org/10.2174/2211556011302010066 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Structure Based Lead Optimization Approach in Discovery of Selective DPP4 Inhibitors
Mini-Reviews in Medicinal Chemistry The Association between Tumor-associated Macrophages and Glioblastoma: A Potential Target for Therapy
Current Pharmaceutical Design Targeting Proteasomes with Naturally Occurring Compounds in Cancer Treatment
Current Cancer Drug Targets Nanostructured Lipid Carriers (NLCs) for Drug Delivery: Role of Liquid Lipid (Oil)
Current Drug Delivery Subject Index To Volume 12
Current Pharmaceutical Design The Therapeutic Potential of Toll-Like Receptor 7 Stimulation in Asthma
Inflammation & Allergy - Drug Targets (Discontinued) Current Status of Epigenetics and Anticancer Drug Discovery
Anti-Cancer Agents in Medicinal Chemistry In Vitro Blood-Brain Barrier Models – Latest Advances and Therapeutic Applications in a Chronological Perspective
Mini-Reviews in Medicinal Chemistry Computational Analysis of miRNA and their Gene Targets Significantly Involved in Colorectal Cancer Progression
MicroRNA Peripheral Benzodiazepine Receptor (PBR) New Insight in Cell Proliferation and Cell Differentiation Review
Current Clinical Pharmacology Molecular Mechanism of Anti-tumor Effect by Triptolide in Hematological Malignancies
Current Signal Transduction Therapy RGD Peptide–mediated Molecular Imaging for Targeting Integrin Alpha(v) Beta(3) in Tumors: A Review
Current Medical Imaging Herpes Simplex Viruses in Antiviral Drug Discovery
Current Pharmaceutical Design Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
Current Pharmaceutical Biotechnology Blood-Brain Barrier Transport of Drugs for the Treatment of Brain Diseases
CNS & Neurological Disorders - Drug Targets Immunoregulatory and Effector Activities of Nitric Oxide and Reactive Nitrogen Species in Cancer
Current Medicinal Chemistry CCL21 and IFNγ Recruit and Activate Tumor Specific T cells in 3D Scaffold Model of Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
Current Cancer Drug Targets Recent Developments in Chimeric NSAIDs as Anticancer Agents: Teaching an Old Dog a New Trick
Mini-Reviews in Medicinal Chemistry Insulin-Like Growth Factor 2 - The Oncogene and its Accomplices
Current Pharmaceutical Design