Abstract
The delivery of drugs can be improved with the use of different carriers, such as those based on nanoparticles. The nanostructures loaded with the therapeutic molecules should be able to reach the target cells and, what is more, release the drugs efficiently. Ideally, the drugs should be delivered only in the target cells, and not along their way to the cells. For these reasons several approaches have been developed to control the release of the drugs at the desired sites. In this review article we have summarized the reports that describe the use of glutathione to trigger the release of the therapeutic molecules from different nanostructures.
Keywords: Chemotherapy, Copolymers, Disulfide, Drug delivery, Glutathione, Nanomedicine, Nanoparticles.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Glutathione-Triggered Drug Release from Nanostructures
Volume: 14 Issue: 23
Author(s): Alfonso Latorre and Alvaro Somoza
Affiliation:
Keywords: Chemotherapy, Copolymers, Disulfide, Drug delivery, Glutathione, Nanomedicine, Nanoparticles.
Abstract: The delivery of drugs can be improved with the use of different carriers, such as those based on nanoparticles. The nanostructures loaded with the therapeutic molecules should be able to reach the target cells and, what is more, release the drugs efficiently. Ideally, the drugs should be delivered only in the target cells, and not along their way to the cells. For these reasons several approaches have been developed to control the release of the drugs at the desired sites. In this review article we have summarized the reports that describe the use of glutathione to trigger the release of the therapeutic molecules from different nanostructures.
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Cite this article as:
Latorre Alfonso and Somoza Alvaro, Glutathione-Triggered Drug Release from Nanostructures, Current Topics in Medicinal Chemistry 2014; 14 (23) . https://dx.doi.org/10.2174/1568026614666141215143659
DOI https://dx.doi.org/10.2174/1568026614666141215143659 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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