Abstract
Background: Diabetic Ketoacidosis (DKA) is one of the most commonly encountered diabetic complication emergencies. It typically affects people with type 1 diabetes at the onset of the disease. It can also affect people with type 2 diabetes, although this is uncommon.
Methods: Research and online content related to diabetes online activity is reviewed. DKA is caused by a relative or absolute deficiency of insulin and elevated levels of counter-regulatory hormones.
Results: Goals of therapy are to correct dehydration, acidosis, and to reverse ketosis, gradually restoring blood glucose concentration to near normal.
Conclusion: It is essential to monitor potential complications of DKA and, if necessary, to treat them and any precipitating events.
Keywords: Type 1 diabetes mellitus, diabetic ketoacidosis, mortality, medicine, glycemic control, insulin pump therapy, complications, children.
Graphical Abstract
[http://dx.doi.org/10.1038/nrendo.2016.15] [PMID: 26893262]
[PMID: 23547550]
[http://dx.doi.org/10.1056/NEJMc1701990] [PMID: 28591538]
[http://dx.doi.org/10.1007/s00125-012-2690-2] [PMID: 22933123]
[http://dx.doi.org/10.1136/bmjopen-2017-016587] [PMID: 28765134]
[http://dx.doi.org/10.1016/j.metabol.2015.12.007] [PMID: 26975543]
[http://dx.doi.org/10.1093/qjmed/hcr226] [PMID: 22109683]
[http://dx.doi.org/10.1002/14651858.CD000567.pub6] [PMID: 23450531]
[http://dx.doi.org/10.3389/fendo.2017.00106] [PMID: 28659865]
[http://dx.doi.org/10.1002/14651858.CD011281.pub2] [PMID: 26798030]
[http://dx.doi.org/10.1016/j.amjmed.2004.05.010] [PMID: 15336577]
[http://dx.doi.org/10.1111/j.1368-5031.2006.00786.x] [PMID: 16620355]
[http://dx.doi.org/10.4239/wjd.v9.i12.226] [PMID: 30588284]
[http://dx.doi.org/10.1016/j.jemermed.2007.11.033] [PMID: 18514472]
[http://dx.doi.org/10.2337/dc06-9909] [PMID: 16644656]
[http://dx.doi.org/10.2337/dc15-0843] [PMID: 26078479]
[http://dx.doi.org/10.1542/peds.2013-2795] [PMID: 24685959]
[http://dx.doi.org/10.2337/diab.20.4.228] [PMID: 4994561]
[http://dx.doi.org/10.1016/j.schres.2014.01.043] [PMID: 24581419]
[http://dx.doi.org/10.2165/00024677-200302020-00003] [PMID: 15871546]
[http://dx.doi.org/10.1001/jama.1984.03350230025026] [PMID: 6439896]
[http://dx.doi.org/10.2174/1573399812666160421121307] [PMID: 27097605]
[http://dx.doi.org/10.1111/dom.13012] [PMID: 28517913]
[http://dx.doi.org/10.1097/GRF.0b013e31815a5494] [PMID: 17982337]
[http://dx.doi.org/10.2337/dc17-0186] [PMID: 28606900]
[http://dx.doi.org/10.1016/S0140-6736(08)60074-4] [PMID: 18177778]
[http://dx.doi.org/10.1159/000013607] [PMID: 10970986]
[http://dx.doi.org/10.1197/aemj.10.8.836] [PMID: 12896883]
[http://dx.doi.org/10.1111/dme.12604] [PMID: 25307274]
[http://dx.doi.org/10.1136/adc.2003.044875] [PMID: 14736641]
[http://dx.doi.org/10.1056/NEJMoa1716816] [PMID: 29897851]
[http://dx.doi.org/10.1111/j.1399-5448.2009.00536.x] [PMID: 19602154]
[http://dx.doi.org/10.2337/diacare.13.1.22] [PMID: 2105195]
[http://dx.doi.org/10.1007/BF00263548] [PMID: 3104431]
[http://dx.doi.org/10.1111/j.1399-5448.2009.00511.x] [PMID: 19821944]
[http://dx.doi.org/10.2337/db07-1410] [PMID: 18633109]
[http://dx.doi.org/10.1034/j.1399-5448.2001.002003109.x] [PMID: 15016193]
[http://dx.doi.org/10.2337/diaclin.32.1.28] [PMID: 26246676]
[http://dx.doi.org/10.2337/dc09-0169] [PMID: 19366972]
[http://dx.doi.org/10.1111/j.1464-5491.2011.03246.x] [PMID: 21255074]
[http://dx.doi.org/10.15585/mmwr.mm6712a3] [PMID: 29596400]
[http://dx.doi.org/10.1111/dom.13811] [PMID: 31183975]
[http://dx.doi.org/10.1111/pedi.12741] [PMID: 30079506]
[http://dx.doi.org/10.1056/NEJMoa1708337] [PMID: 28899222]
[http://dx.doi.org/10.1136/bmj.l1328] [PMID: 30967375]