Progress of Oral Insulin and Related Drug Delivery Systems and their Pharmacokinetics

Title:Progress of Oral Insulin and Related Drug Delivery Systems and their Pharmacokinetics

Volume: 19 Issue: 10

Author(s): Jingjing Chen, Rui Liu*, Changxiao Liu*, Xin Jin, Qinghua Zhang, Jialu Wang, Fang Zhao, Ze Wang, Haiyan Qiu, Yazhuo Li and Xiulin Yi

Affiliation:

• School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin,China

• School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin,China

Keywords: Diabetes, insulin, oral preparation, dosage forms, progress, drug delivery systems, metabolism.

Abstract: Background: As society has developed and living standards have improved, diabetes has become a severe public health issue. Insulin plays a crucial role in managing hyperglycemia caused by type I diabetes and particular type II diabetes. Many researchers are seeking alternative, more acceptable methods of insulin delivery, such as oral insulin. An oral formulation has become a new goal for insulin delivery in recent years.

Methods: The PubMed and CNKI databases were searched for “oral insulin, ” “drug delivery systems, ” and “pharmacokinetics, ” and 85 relevant articles were selected from the results as material for this review. These papers were authoritative and had a higher number of citations.

Results: Oral insulin would be highly advantageous but is poorly absorbed. The main reason for low absorptivity is the hydrolysis of insulin by enzymes in the gastrointestinal tract. Lack of active transport vectors that pass through the intestinal epithelium is also a non-negligible problem. Additional issues need to be considered to facilitate appropriate research, such as long-term efficacy and safety, clinical data, and toxicological characteristics.

Conclusion: This review summarized recent advances in oral insulin and the pharmacokinetic profile of the suitable delivery system, providing valuable reference material for future research.

Cite this article as:

Chen Jingjing, Liu Rui*, Liu Changxiao*, Jin Xin , Zhang Qinghua , Wang Jialu , Zhao Fang , Wang Ze, Qiu Haiyan , Li Yazhuo and Yi Xiulin , Progress of Oral Insulin and Related Drug Delivery Systems and their Pharmacokinetics, Current Drug Metabolism 2018; 19 (10) . https://dx.doi.org/10.2174/1389200219666180523101434