Exercise and Nutraceuticals: Eminent Approach for Diabetic Neuropathy

Amos, A.F.; McCarty, D.J.; Zimmet, P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet. Med., 1997, 14(Suppl. 5), S1-S85.
[http://dx.doi.org/10.1002/(SICI)1096-9136(199712)14:5+<S7::AID-DIA522>3.0.CO;2-R] [PMID: 9450510]

Feldman, E.L.; Callaghan, B.C.; Pop-Busui, R.; Zochodne, D.W.; Wright, D.E.; Bennett, D.L.; Bril, V.; Russell, J.W.; Viswanathan, V. Diabetic neuropathy. Nat. Rev. Dis. Primers, 2019, 5(1), 41.
[http://dx.doi.org/10.1038/s41572-019-0092-1] [PMID: 31197153]

King, H.; Aubert, R.E.; Herman, W.H. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care, 1998, 21(9), 1414-1431.
[http://dx.doi.org/10.2337/diacare.21.9.1414] [PMID: 9727886]

Çakici, N.; Fakkel, T.M.; van Neck, J.W.; Verhagen, A.P.; Coert, J.H. Systematic review of treatments for diabetic peripheral neuropathy. Diabet. Med., 2016, 33(11), 1466-1476.
[http://dx.doi.org/10.1111/dme.13083] [PMID: 26822889]

World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. World Health Organization, 1999.

Fasanmade, O.A.; Odeniyi, I.A.; Ogbera, A.O. Diabetic ketoacidosis: Diagnosis and management. Afr. J. Med. Med. Sci., 2008, 37(2), 99-105.
[PMID: 18939392]

Kitabchi, A.E.; Nyenwe, E.A. Hyperglycemic crises in diabetes mellitus: Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Endocrinol. Metab. Clin. North Am., 2006, 35(4), 725-751, viii.
[http://dx.doi.org/10.1016/j.ecl.2006.09.006] [PMID: 17127143]

Fong, D.S.; Aiello, L.P.; Ferris, F.L., III; Klein, R. Diabetic retinopathy. Diabetes Care, 2004, 27(10), 2540-2553.
[http://dx.doi.org/10.2337/diacare.27.10.2540] [PMID: 15451934]

Huang, D.; Refaat, M.; Mohammedi, K.; Jayyousi, A.; Al Suwaidi, J.; Abi Khalil, C. Macrovascular complications in patients with diabetes and prediabetes. BioMed Res. Int., 2017, 2017, 7839101.
[http://dx.doi.org/10.1155/2017/7839101] [PMID: 29238721]

Cole, J.B.; Florez, J.C. Genetics of diabetes mellitus and diabetes complications. Nat. Rev. Nephrol., 2020, 16(7), 377-390.
[http://dx.doi.org/10.1038/s41581-020-0278-5] [PMID: 32398868]

Agashe, S.; Petak, S. Cardiac autonomic neuropathy in diabetes mellitus. Methodist DeBakey Cardiovasc. J., 2018, 14(4), 251-256.
[PMID: 30788010]

Moheet, A.; Mangia, S.; Seaquist, E.R. Impact of diabetes on cognitive function and brain structure. Ann. N. Y. Acad. Sci., 2015, 1353, 60-71.
[http://dx.doi.org/10.1111/nyas.12807] [PMID: 26132277]

Ljubimov, A.V. Diabetic complications in the cornea. Vision Res., 2017, 139, 138-152.
[http://dx.doi.org/10.1016/j.visres.2017.03.002] [PMID: 28404521]

Ritz, E.; Orth, S.R. Nephropathy in patients with type 2 diabetes mellitus. N. Engl. J. Med., 1999, 341(15), 1127-1133.
[http://dx.doi.org/10.1056/NEJM199910073411506] [PMID: 10511612]

Grundy, S.M.; Benjamin, I.J.; Burke, G.L.; Chait, A.; Eckel, R.H.; Howard, B.V.; Mitch, W.; Smith, S.C., Jr; Sowers, J.R. Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association. Circulation, 1999, 100(10), 1134-1146.
[http://dx.doi.org/10.1161/01.CIR.100.10.1134] [PMID: 10477542]

American Diabetes Association. Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care, 1999, 22(8), 1354-1360.
[http://dx.doi.org/10.2337/diacare.22.8.1354] [PMID: 10480782]

New concepts in diabetes and its treatment; Belfiore, F.; Mogensen, C.E Eds.; Karger: Basel, 2000.

National Diabetes Information Clearinghouse. Diabetic neuropathies: The nerve damage of diabetes. 2009. Available from: https://static1.squarespace.com/static/54f8bdc9e4b05ef254a56822/t/58751662cd0f68e66cafc11f/1484068452930/Neuropathies_508.pdf (Accessed on December 1, 2021).

Boulton, A.J.M.; Gries, F.A.; Jervell, J.A. Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. Diabet. Med., 1998, 15(6), 508-514.
[http://dx.doi.org/10.1002/(SICI)1096-9136(199806)15:6<508::AID-DIA613>3.0.CO;2-L] [PMID: 9632127]

Talbot, S.; Couture, R. Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy. Exp. Neurol., 2012, 234(2), 373-381.
[http://dx.doi.org/10.1016/j.expneurol.2011.11.032] [PMID: 22154922]

Tavakoli, M.; Asghar, O.; Alam, U.; Petropoulos, I.N.; Fadavi, H.; Malik, R.A. Novel insights on diagnosis, cause and treatment of diabetic neuropathy: Focus on painful diabetic neuropathy. Ther. Adv. Endocrinol. Metab., 2010, 1(2), 69-88.
[http://dx.doi.org/10.1177/2042018810370954] [PMID: 23148152]

Azhary, H.; Farooq, M.U.; Bhanushali, M.; Majid, A.; Kassab, M.Y. Peripheral neuropathy: Differential diagnosis and management. Am. Fam. Physician, 2010, 81(7), 887-892.
[PMID: 20353146]

Gordon Smith, A.; Robinson Singleton, J. Idiopathic neuropathy, prediabetes and the metabolic syndrome. J. Neurol. Sci., 2006, 242(1-2), 9-14.
[http://dx.doi.org/10.1016/j.jns.2005.11.020] [PMID: 16448668]

Max, M.B.; Culnane, M.; Schafer, S.C.; Gracely, R.H.; Walther, D.J.; Smoller, B.; Dubner, R. Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed mood. Neurology, 1987, 37(4), 589-596.
[http://dx.doi.org/10.1212/WNL.37.4.589] [PMID: 2436092]

Max, M.B.; Lynch, S.A.; Muir, J.; Shoaf, S.E.; Smoller, B.; Dubner, R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N. Engl. J. Med., 1992, 326(19), 1250-1256.
[http://dx.doi.org/10.1056/NEJM199205073261904] [PMID: 1560801]

Sindrup, S.H.; Gram, L.F.; Skjold, T.; Frøland, A.; Beck-Nielsen, H. Concentration-response relationship in imipramine treatment of diabetic neuropathy symptoms. Clin. Pharmacol. Ther., 1990, 47(4), 509-515.
[http://dx.doi.org/10.1038/clpt.1990.65] [PMID: 2328559]

Sindrup, S.H.; Gram, L.F.; Skjold, T.; Grodum, E.; Brøsen, K.; Beck-Nielsen, H. Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study. Br. J. Clin. Pharmacol., 1990, 30(5), 683-691.
[http://dx.doi.org/10.1111/j.1365-2125.1990.tb03836.x] [PMID: 2271367]

Sindrup, S.H.; Bjerre, U.; Dejgaard, A.; Brøsen, K.; Aaes-Jørgensen, T.; Gram, L.F. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin. Pharmacol. Ther., 1992, 52(5), 547-552.
[http://dx.doi.org/10.1038/clpt.1992.183] [PMID: 1424428]

Rowbotham, M.C.; Goli, V.; Kunz, N.R.; Lei, D. Venlafaxine extended release in the treatment of painful diabetic neuropathy: A double-blind, placebo-controlled study. Pain, 2004, 110(3), 697-706.
[http://dx.doi.org/10.1016/j.pain.2004.05.010] [PMID: 15288411]

Goldstein, D.J.; Lu, Y.; Detke, M.J.; Lee, T.C.; Iyengar, S. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain, 2005, 116(1-2), 109-118.
[http://dx.doi.org/10.1016/j.pain.2005.03.029] [PMID: 15927394]

Backonja, M.; Beydoun, A.; Edwards, K.R.; Schwartz, S.L.; Fonseca, V.; Hes, M.; LaMoreaux, L.; Garofalo, E. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial. JAMA, 1998, 280(21), 1831-1836.
[http://dx.doi.org/10.1001/jama.280.21.1831] [PMID: 9846777]

Rosenstock, J.; Tuchman, M.; LaMoreaux, L.; Sharma, U. Pregabalin for the treatment of painful diabetic peripheral neuropathy: A double-blind, placebo-controlled trial. Pain, 2004, 110(3), 628-638.
[http://dx.doi.org/10.1016/j.pain.2004.05.001] [PMID: 15288403]

Eisenberg, E.; Lurie, Y.; Braker, C.; Daoud, D.; Ishay, A. Lamotrigine reduces painful diabetic neuropathy: A randomized, controlled study. Neurology, 2001, 57(3), 505-509.
[http://dx.doi.org/10.1212/WNL.57.3.505] [PMID: 11502921]

Rull, J.A.; Quibrera, R.; González-Millán, H.; Lozano Castañeda, O. Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): Double blind crossover trial. Diabetologia, 1969, 5(4), 215-218.
[http://dx.doi.org/10.1007/BF01212087] [PMID: 4902717]

Raskin, P.; Donofrio, P.D.; Rosenthal, N.R.; Hewitt, D.J.; Jordan, D.M.; Xiang, J.; Vinik, A.I. Topiramate vs placebo in painful diabetic neuropathy: Analgesic and metabolic effects. Neurology, 2004, 63(5), 865-873.
[http://dx.doi.org/10.1212/01.WNL.0000137341.89781.14] [PMID: 15365138]

Harati, Y.; Gooch, C.; Swenson, M.; Edelman, S.; Greene, D.; Raskin, P.; Donofrio, P.; Cornblath, D.; Sachdeo, R.; Siu, C.O.; Kamin, M. Double-blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy. Neurology, 1998, 50(6), 1842-1846.
[http://dx.doi.org/10.1212/WNL.50.6.1842] [PMID: 9633738]

Gimbel, J.S.; Richards, P.; Portenoy, R.K. Controlled-release oxycodone for pain in diabetic neuropathy: A randomized controlled trial. Neurology, 2003, 60(6), 927-934.
[http://dx.doi.org/10.1212/01.WNL.0000057720.36503.2C] [PMID: 12654955]

Sang, C.N.; Booher, S.; Gilron, I.; Parada, S.; Max, M.B. Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: Efficacy and dose-response trials. Anesthesiology, 2002, 96(5), 1053-1061.
[http://dx.doi.org/10.1097/00000542-200205000-00005] [PMID: 11981142]

Dailey, G.E.; Muchmore, D.P.; Springer, J.W.; Donofrio, P.D.; Walker, F.O.; Hunt, V.P.; Tandan, R.; Fries, T.J.; Lewis, G.; Ramamurthy, S.; Walsh, N.; Hoffmann, J.; Scheffler, N.M.; Sheitel, P.L.; Wendt, J.; Thomas, J.C.; Kurent, J.E.; Whitehouse, F.W.; Basha, K.M. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care, 1992, 15(2), 159-165.
[http://dx.doi.org/10.2337/diacare.15.2.159] [PMID: 1547671]

Prakash, S.; Gosai, F.; Brahmbhatt, J.; Shah, C. Serotonin syndrome in patients with peripheral neuropathy: A diagnostic challenge. Gen. Hosp. Psychiatry, 2014, 36(4), 450.e9-450.e11.
[http://dx.doi.org/10.1016/j.genhosppsych.2014.03.012] [PMID: 24768426]

de Abajo, F.J.; García-Rodríguez, L.A. Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: Interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents. Arch. Gen. Psychiatry, 2008, 65(7), 795-803.
[http://dx.doi.org/10.1001/archpsyc.65.7.795] [PMID: 18606952]

Zychowska, M.; Rojewska, E.; Przewlocka, B.; Mika, J. Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies. Pharmacol. Rep., 2013, 65(6), 1601-1610.
[http://dx.doi.org/10.1016/S1734-1140(13)71521-4] [PMID: 24553008]

Colberg, S.R.; Vinik, A.I. Exercising with peripheral or autonomic neuropathy: What health care providers and diabetic patients need to know. Phys. Sportsmed., 2014, 42(1), 15-23.
[http://dx.doi.org/10.3810/psm.2014.02.2043] [PMID: 24565817]

Rajasekaran, a.; Sivagnanam, G.; Xavier, R. Nutraceuticals as therapeutic agents : A review. Res. J. Pharm. Tech, 2008, 1(4), 328-40.

Zilliox, L.A.; Russell, J.W. Physical activity and dietary interventions in diabetic neuropathy: A systematic review. Clin. Auton. Res., 2019, 29(4), 443-455.
[http://dx.doi.org/10.1007/s10286-019-00607-x] [PMID: 31076938]

Kong, M.F.; Horowitz, M.; Jones, K.L.; Wishart, J.M.; Harding, P.E. Natural history of diabetic gastroparesis. Diabetes Care, 1999, 22(3), 503-507.
[http://dx.doi.org/10.2337/diacare.22.3.503] [PMID: 10097936]

Maser, R.E.; Mitchell, B.D.; Vinik, A.I.; Freeman, R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: A meta-analysis. Diabetes Care, 2003, 26(6), 1895-1901.
[http://dx.doi.org/10.2337/diacare.26.6.1895] [PMID: 12766130]

Dewanjee, S.; Das, S.; Das, A.K.; Bhattacharjee, N.; Dihingia, A.; Dua, T.K.; Kalita, J.; Manna, P. Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets. Eur. J. Pharmacol., 2018, 833, 472-523.
[http://dx.doi.org/10.1016/j.ejphar.2018.06.034] [PMID: 29966615]

Feldman, E.L.; Nave, K.A.; Jensen, T.S.; Bennett, D.L.H. New horizons in diabetic neuropathy: Mechanisms, bioenergetics, and pain. Neuron, 2017, 93(6), 1296-1313.
[http://dx.doi.org/10.1016/j.neuron.2017.02.005] [PMID: 28334605]

Nakamura, J.; Kato, K.; Hamada, Y.; Nakayama, M.; Chaya, S.; Nakashima, E.; Naruse, K.; Kasuya, Y.; Mizubayashi, R.; Miwa, K.; Yasuda, Y.; Kamiya, H.; Ienaga, K.; Sakakibara, F.; Koh, N.; Hotta, N. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes, 1999, 48(10), 2090-2095.
[http://dx.doi.org/10.2337/diabetes.48.10.2090] [PMID: 10512378]

Vincent, A.M.; Russell, J.W.; Low, P.; Feldman, E.L. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr. Rev., 2004, 25(4), 612-628.
[http://dx.doi.org/10.1210/er.2003-0019] [PMID: 15294884]

Brownlee, M. The pathobiology of diabetic complications: A unifying mechanism. Diabetes, 2005, 54(6), 1615-1625.
[http://dx.doi.org/10.2337/diabetes.54.6.1615] [PMID: 15919781]

Jermendy, G.; Tóth, L.; Vörös, P.; Koltai, M.Z.; Pogátsa, G. QT interval in diabetic autonomic neuropathy. Diabet. Med., 1990, 7(8), 750.
[http://dx.doi.org/10.1111/j.1464-5491.1990.tb01482.x] [PMID: 2147640]

Stevens, M.J.; Feldman, E.L.; Thomas, T.; Greene, D.A. Pathogenesis of diabetic neuropathy. In: Clinical Management of Diabetic Neuropathy; Veves, A., Ed.; , 1998; 7, pp. 13-48.
[http://dx.doi.org/10.1007/978-1-4612-1816-6_2]

Uehara, K.; Yamagishi, S.; Otsuki, S.; Chin, S.; Yagihashi, S. Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice. Diabetes, 2004, 53(12), 3239-3247.
[http://dx.doi.org/10.2337/diabetes.53.12.3239] [PMID: 15561956]

Yamagishi, S.; Uehara, K.; Otsuki, S.; Yagihashi, S. Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice. J. Neurochem., 2003, 87(2), 497-507.
[http://dx.doi.org/10.1046/j.1471-4159.2003.02011.x] [PMID: 14511127]

Thornalley, P.J. The potential role of thiamine (vitamin B1) in diabetic complications. Curr. Diabetes Rev., 2005, 1(3), 287-298.
[http://dx.doi.org/10.2174/157339905774574383] [PMID: 18220605]

Brownlee, M. Biochemistry and molecular cell biology of diabetic complications. Nature, 2001, 414(6865), 813-820.
[http://dx.doi.org/10.1038/414813a] [PMID: 11742414]

Kolm-Litty, V.; Sauer, U.; Nerlich, A.; Lehmann, R.; Schleicher, E.D. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. J. Clin. Invest., 1998, 101(1), 160-169.
[http://dx.doi.org/10.1172/JCI119875] [PMID: 9421478]

Sayeski, P.P.; Kudlow, J.E. Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-α gene transcription. J. Biol. Chem., 1996, 271(25), 15237-15243.
[http://dx.doi.org/10.1074/jbc.271.25.15237] [PMID: 8663078]

Du, X.L.; Edelstein, D.; Rossetti, L.; Fantus, I.G.; Goldberg, H.; Ziyadeh, F.; Wu, J.; Brownlee, M. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc. Natl. Acad. Sci. USA, 2000, 97(22), 12222-12226.
[http://dx.doi.org/10.1073/pnas.97.22.12222] [PMID: 11050244]

Hirakata, Y.; Kitamura, S. Elevated serum transforming growth factor beta 1 level in primary lung cancer patients with finger clubbing. Eur. J. Clin. Invest., 1996, 26(9), 820-823.
[http://dx.doi.org/10.1046/j.1365-2362.1996.2260560.x] [PMID: 8889446]

Kaneto, H.; Xu, G.; Song, K-H.; Suzuma, K.; Bonner-Weir, S.; Sharma, A.; Weir, G.C. Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function through the induction of oxidative stress. J. Biol. Chem., 2001, 276(33), 31099-31104.
[http://dx.doi.org/10.1074/jbc.M104115200] [PMID: 11390407]

Arikawa, E.; Ma, R.C.W.; Isshiki, K.; Luptak, I.; He, Z.; Yasuda, Y.; Maeno, Y.; Patti, M.E.; Weir, G.C.; Harris, R.A.; Zammit, V.A.; Tian, R.; King, G.L. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta’s actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes, 2007, 56(5), 1410-1420.
[http://dx.doi.org/10.2337/db06-0655] [PMID: 17363743]

Das Evcimen, N.; King, G.L. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol. Res., 2007, 55(6), 498-510.
[http://dx.doi.org/10.1016/j.phrs.2007.04.016] [PMID: 17574431]

Veves, A.; King, G.L. Can VEGF reverse diabetic neuropathy in human subjects? J. Clin. Invest., 2001, 107(10), 1215-1218.
[http://dx.doi.org/10.1172/JCI13038] [PMID: 11375408]

Edwards, A.S.; Faux, M.C.; Scott, J.D.; Newton, A.C. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J. Biol. Chem., 1999, 274(10), 6461-6468.
[http://dx.doi.org/10.1074/jbc.274.10.6461] [PMID: 10037738]

Williams, B.; Gallacher, B.; Patel, H.; Orme, C. Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes, 1997, 46(9), 1497-1503.
[http://dx.doi.org/10.2337/diab.46.9.1497] [PMID: 9287052]

Xia, P.; Kramer, R.M.; King, G.L. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J. Clin. Invest., 1995, 96(2), 733-740.
[http://dx.doi.org/10.1172/JCI118117] [PMID: 7635966]

Cortright, R.N.; Azevedo, J.L., Jr; Zhou, Q.; Sinha, M.; Pories, W.J.; Itani, S.I.; Dohm, G.L. Protein kinase C modulates insulin action in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab., 2000, 278(3), E553-E562.
[http://dx.doi.org/10.1152/ajpendo.2000.278.3.E553] [PMID: 10710511]

Ahmed, N. Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pract., 2005, 67(1), 3-21.
[http://dx.doi.org/10.1016/j.diabres.2004.09.004] [PMID: 15620429]

Toth, C.; Rong, L.L.; Yang, C.; Martinez, J.; Song, F.; Ramji, N.; Brussee, V.; Liu, W.; Durand, J.; Nguyen, M.D.; Schmidt, A.M.; Zochodne, D.W. Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy. Diabetes, 2008, 57(4), 1002-1017.
[http://dx.doi.org/10.2337/db07-0339] [PMID: 18039814]

Yao, D.; Taguchi, T.; Matsumura, T.; Pestell, R.; Edelstein, D.; Giardino, I.; Suske, G.; Rabbani, N.; Thornalley, P.J.; Sarthy, V.P.; Hammes, H.P.; Brownlee, M. High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J. Biol. Chem., 2007, 282(42), 31038-31045.
[http://dx.doi.org/10.1074/jbc.M704703200] [PMID: 17670746]

Ramasamy, R.; Vannucci, S.J.; Yan, S.S.; Herold, K.; Yan, S.F.; Schmidt, A.M. Advanced glycation end products and RAGE: A common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology, 2005, 15(7), 16R-28R.
[http://dx.doi.org/10.1093/glycob/cwi053] [PMID: 15764591]

Vincent, A.M.; Perrone, L.; Sullivan, K.A.; Backus, C.; Sastry, A.M.; Lastoskie, C.; Feldman, E.L. Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress. Endocrinology, 2007, 148(2), 548-558.
[http://dx.doi.org/10.1210/en.2006-0073] [PMID: 17095586]

Kislinger, T.; Tanji, N.; Wendt, T.; Qu, W.; Lu, Y.; Ferran, L.J., Jr; Taguchi, A.; Olson, K.; Bucciarelli, L.; Goova, M.; Hofmann, M.A.; Cataldegirmen, G.; D’Agati, V.; Pischetsrieder, M.; Stern, D.M.; Schmidt, A.M. Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice. Arterioscler. Thromb. Vasc. Biol., 2001, 21(6), 905-910.
[http://dx.doi.org/10.1161/01.ATV.21.6.905] [PMID: 11397695]

Wada, R.; Yagihashi, S. Role of advanced glycation end products and their receptors in development of diabetic neuropathy. Ann. N. Y. Acad. Sci., 2005, 1043, 598-604.
[http://dx.doi.org/10.1196/annals.1338.067] [PMID: 16037282]

Obrosova, I.G.; Drel, V.R.; Pacher, P.; Ilnytska, O.; Wang, Z.Q.; Stevens, M.J.; Yorek, M.A. Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: The relation is revisited. Diabetes, 2005, 54(12), 3435-3441.
[http://dx.doi.org/10.2337/diabetes.54.12.3435] [PMID: 16306359]

Du, X.; Matsumura, T.; Edelstein, D.; Rossetti, L.; Zsengellér, Z.; Szabó, C.; Brownlee, M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J. Clin. Invest., 2003, 112(7), 1049-1057.
[http://dx.doi.org/10.1172/JCI18127] [PMID: 14523042]

Virág, L.; Jagtap, P.; Szabó, E.; Mabley, J.G.; Liaudet, L.; Marton, A.; Hoyt, D.G.; Murthy, K.G.; Salzman, A.L.; Southan, G.J.; Szabó, C.; Szabó, C. Diabetic endothelial dysfunction: The role of poly(ADP-ribose) polymerase activation. Nat. Med., 2001, 7(1), 108-113.
[http://dx.doi.org/10.1038/83241] [PMID: 11135624]

Ha, H.C.; Hester, L.D.; Snyder, S.H. Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc. Natl. Acad. Sci. USA, 2002, 99(5), 3270-3275.
[http://dx.doi.org/10.1073/pnas.052712399] [PMID: 11854472]

Ilnytska, O.; Lyzogubov, V.V.; Stevens, M.J.; Drel, V.R.; Mashtalir, N.; Pacher, P.; Yorek, M.A.; Obrosova, I.G. Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy. Diabetes, 2006, 55(6), 1686-1694.
[http://dx.doi.org/10.2337/db06-0067] [PMID: 16731831]

Li, F.; Drel, V.R.; Szabó, C.; Stevens, M.J.; Obrosova, I.G. Low- dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy. Diabetes, 2005, 54(5), 1514-1522.
[http://dx.doi.org/10.2337/diabetes.54.5.1514] [PMID: 15855340]

Obrosova, I.G.; Li, F.; Abatan, O.I.; Forsell, M.A.; Komjáti, K.; Pacher, P.; Szabó, C.; Stevens, M.J. Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy. Diabetes, 2004, 53(3), 711-720.
[http://dx.doi.org/10.2337/diabetes.53.3.711] [PMID: 14988256]

Pacher, P.; Liaudet, L.; Soriano, F.G.; Mabley, J.G.; Szabó, E.; Szabó, C. The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes. Diabetes, 2002, 51(2), 514-521.
[http://dx.doi.org/10.2337/diabetes.51.2.514] [PMID: 11812763]

Zheng, L.; Szabó, C.; Kern, T.S. Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes, 2004, 53(11), 2960-2967.
[http://dx.doi.org/10.2337/diabetes.53.11.2960] [PMID: 15504977]

Gomes, M.B.; Piccirillo, L.J.; Nogueira, V.G.; Matos, H.J. Acute-phase proteins among patients with type 1 diabetes. Diabetes Metab., 2003, 29(4 Pt 1), 405-411.
[http://dx.doi.org/10.1016/S1262-3636(07)70051-4] [PMID: 14526268]

González-Clemente, J.M.; Mauricio, D.; Richart, C.; Broch, M.; Caixàs, A.; Megia, A.; Giménez-Palop, O.; Simón, I.; Martínez-Riquelme, A.; Giménez-Pérez, G.; Vendrell, J. Diabetic neuropathy is associated with activation of the TNF-α system in subjects with type 1 diabetes mellitus. Clin. Endocrinol. (Oxf.), 2005, 63(5), 525-529.
[http://dx.doi.org/10.1111/j.1365-2265.2005.02376.x] [PMID: 16268804]

Vincent, A.M.; Feldman, E.L. New insights into the mechanisms of diabetic neuropathy. Rev. Endocr. Metab. Disord., 2004, 5(3), 227-236.
[http://dx.doi.org/10.1023/B:REMD.0000032411.11422.e0] [PMID: 15211094]

Coppey, L.J.; Davidson, E.P.; Rinehart, T.W.; Gellett, J.S.; Oltman, C.L.; Lund, D.D.; Yorek, M.A. ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy in streptozotocin-induced diabetic rats. Diabetes, 2006, 55(2), 341-348.
[http://dx.doi.org/10.2337/diabetes.55.02.06.db05-0885] [PMID: 16443766]

Hasnis, E.; Bar-Shai, M.; Burbea, Z.; Reznick, A.Z. Mechanisms underlying cigarette smoke-induced nf-kb activation in human lymphocytes: The role of reactive nitrogen species. J. Physiol. Pharmacol., 2007, 58(Suppl. 5; Pt 1), 275-287.

Kim, Y.W.; Zhao, R.J.; Park, S.J.; Lee, J.R.; Cho, I.J.; Yang, C.H.; Kim, S.G.; Kim, S.C. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of nf-kb-dependent inos and proinflammatory cytokines production. Br. J. Pharmacol., 2008, 154(1), 165-73.
[http://dx.doi.org/10.1038/bjp.2008.79]

Kellogg, A.P.; Wiggin, T.D.; Larkin, D.D.; Hayes, J.M.; Stevens, M.J.; Pop-Busui, R. Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. Diabetes, 2007, 56(12), 2997-3005.
[http://dx.doi.org/10.2337/db07-0740] [PMID: 17720896]

Matsunaga, A.; Kawamoto, M.; Shiraishi, S.; Yasuda, T.; Kajiyama, S.; Kurita, S.; Yuge, O. Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats. Eur. J. Pharmacol., 2007, 554(1), 12-17.
[http://dx.doi.org/10.1016/j.ejphar.2006.09.072] [PMID: 17112505]

Levy, D.; Zochodne, D.W.N.O. NO pain: Potential roles of nitric oxide in neuropathic pain. Pain Pract., 2004, 4(1), 11-18.
[http://dx.doi.org/10.1111/j.1533-2500.2004.04002.x] [PMID: 17129298]

Zochodne, D.W.; Levy, D. Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell. Mol. Biol., 2005, 51(3), 255-267.
[PMID: 16191393]

McDonald, D.S.; Cheng, C.; Martinez, J.A.; Zochodne, D.W. Regenerative arrest of inflamed peripheral nerves: Role of nitric oxide. Neuroreport, 2007, 18(16), 1635-1640.
[http://dx.doi.org/10.1097/WNR.0b013e3282f03fff] [PMID: 17921859]

Nishikawa, T.; Edelstein, D.; Du, X.L.; Yamagishi, S.; Matsumura, T.; Kaneda, Y.; Yorek, M.A.; Beebe, D.; Oates, P.J.; Hammes, H-P.; Giardino, I.; Brownlee, M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature, 2000, 404(6779), 787-790.
[http://dx.doi.org/10.1038/35008121] [PMID: 10783895]

Obrosova, I.G.; Drel, V.R.; Oltman, C.L.; Mashtalir, N.; Tibrewala, J.; Groves, J.T.; Yorek, M.A. Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats. Am. J. Physiol. Endocrinol. Metab., 2007, 293(6), E1645-E1655.
[http://dx.doi.org/10.1152/ajpendo.00479.2007] [PMID: 17911342]

Obrosova, I.G.; Mabley, J.G.; Zsengellér, Z.; Charniauskaya, T.; Abatan, O.I.; Groves, J.T.; Szabó, C. Role for nitrosative stress in diabetic neuropathy: Evidence from studies with a peroxynitrite decomposition catalyst. FASEB J., 2005, 19(3), 401-403.
[http://dx.doi.org/10.1096/fj.04-1913fje] [PMID: 15611153]

Leinninger, G.M.; Edwards, J.L.; Lipshaw, M.J.; Feldman, E.L. Mechanisms of disease: Mitochondria as new therapeutic targets in diabetic neuropathy. Nat. Clin. Pract. Neurol., 2006, 2(11), 620-628.
[http://dx.doi.org/10.1038/ncpneuro0320] [PMID: 17057749]

Obrosova, I.G.; Julius, U.A. Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy. Curr. Vasc. Pharmacol., 2005, 3(3), 267-283.
[http://dx.doi.org/10.2174/1570161054368634] [PMID: 16026323]

Obrosova, I.G.; Van Huysen, C.; Fathallah, L.; Cao, X.C.; Greene, D.A.; Stevens, M.J. An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense. FASEB J., 2002, 16(1), 123-125.
[http://dx.doi.org/10.1096/fj.01-0603fje] [PMID: 11709499]

PKC-DRS Study Group. The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes, 2005, 54(7), 2188-2197.
[http://dx.doi.org/10.2337/diabetes.54.7.2188] [PMID: 15983221]

Wada, R.; Nishizawa, Y.; Yagihashi, N.; Takeuchi, M.; Ishikawa, Y.; Yasumura, K.; Nakano, M.; Yagihashi, S. Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy. Eur. J. Clin. Invest., 2001, 31(6), 513-520.
[http://dx.doi.org/10.1046/j.1365-2362.2001.00826.x] [PMID: 11422401]

Frank, S.; Gaume, B.; Bergmann-Leitner, E.S.; Leitner, W.W.; Robert, E.G.; Catez, F.; Smith, C.L.; Youle, R.J. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell, 2001, 1(4), 515-525.
[http://dx.doi.org/10.1016/S1534-5807(01)00055-7] [PMID: 11703942]

Lee, Y.J.; Jeong, S-Y.; Karbowski, M.; Smith, C.L.; Youle, R.J. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell, 2004, 15(11), 5001-5011.
[http://dx.doi.org/10.1091/mbc.e04-04-0294] [PMID: 15356267]

Balducci, S.; Iacobellis, G.; Parisi, L.; Di Biase, N.; Calandriello, E.; Leonetti, F.; Fallucca, F. Exercise training can modify the natural history of diabetic peripheral neuropathy. J. Diabetes Complications, 2006, 20(4), 216-223.
[http://dx.doi.org/10.1016/j.jdiacomp.2005.07.005] [PMID: 16798472]

Ilha, J.; Araujo, R.T.; Malysz, T.; Hermel, E.E.S.; Rigon, P.; Xavier, L.L.; Achaval, M. Endurance and resistance exercise training programs elicit specific effects on sciatic nerve regeneration after experimental traumatic lesion in rats. Neurorehabil. Neural Repair, 2008, 22(4), 355-366.
[http://dx.doi.org/10.1177/1545968307313502] [PMID: 18326889]

Malysz, T.; Ilha, J.; Nascimento, P.S.; De Angelis, K.; Schaan, B.D.; Achaval, M. Beneficial effects of treadmill training in experimental diabetic nerve regeneration. Clinics (São Paulo), 2010, 65(12), 1329-1337.
[http://dx.doi.org/10.1590/S1807-59322010001200017] [PMID: 21340223]

O’Donnell, J.; Zeppenfeld, D.; McConnell, E.; Pena, S.; Nedergaard, M. Norepinephrine: A neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem. Res., 2012, 37(11), 2496-2512.
[http://dx.doi.org/10.1007/s11064-012-0818-x] [PMID: 22717696]

Li, L.; Manor, B. Long term Tai Chi exercise improves physical performance among people with peripheral neuropathy. Am. J. Chin. Med., 2010, 38(3), 449-459.
[http://dx.doi.org/10.1142/S0192415X1000797X] [PMID: 20503464]

Li, L.; Hondzinski, J.M. Select exercise modalities may reverse movement dysfunction because of peripheral neuropathy. Exerc. Sport Sci. Rev., 2012, 40(3), 133-137.
[http://dx.doi.org/10.1097/JES.0b013e31825f7483] [PMID: 22653276]

Huang, H-H.; Farmer, K.; Windscheffel, J.; Yost, K.; Power, M.; Wright, D.E.; Stehno-Bittel, L. Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice. Exp. Diabetes Res., 2011, 2011, 481427.
[http://dx.doi.org/10.1155/2011/481427] [PMID: 21912535]

Chen, Y-W.; Li, Y-T.; Chen, Y.C.; Li, Z-Y.; Hung, C-H. Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve. Anesth. Analg., 2012, 114(6), 1330-1337.
[http://dx.doi.org/10.1213/ANE.0b013e31824c4ed4] [PMID: 22415536]

Sharma, N.K.; Ryals, J.M.; Gajewski, B.J.; Wright, D.E. Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain. Phys. Ther., 2010, 90(5), 714-725.
[http://dx.doi.org/10.2522/ptj.20090168] [PMID: 20338916]

Selagzi, H.; Buyukakilli, B.; Cimen, B.; Yilmaz, N.; Erdogan, S. Protective and therapeutic effects of swimming exercise training on diabetic peripheral neuropathy of streptozotocin-induced diabetic rats. J. Endocrinol. Invest., 2008, 31(11), 971-978.
[http://dx.doi.org/10.1007/BF03345634] [PMID: 19169052]

Király, M.A.; Bates, H.E.; Yue, J.T.Y.; Goche-Montes, D.; Fediuc, S.; Park, E.; Matthews, S.G.; Vranic, M.; Riddell, M.C. Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: The effects of stress and non-volitional exercise. Metabolism, 2007, 56(6), 732-744.
[http://dx.doi.org/10.1016/j.metabol.2006.12.022] [PMID: 17512304]

Kluding, P.M.; Pasnoor, M.; Singh, R.; D’Silva, L.J.; Yoo, M.; Billinger, S.A.; LeMaster, J.W.; Dimachkie, M.M.; Herbelin, L.; Wright, D.E. Safety of aerobic exercise in people with diabetic peripheral neuropathy: Single-group clinical trial. Phys. Ther., 2015, 95(2), 223-234.
[http://dx.doi.org/10.2522/ptj.20140108] [PMID: 25278335]

Lemaster, J.W.; Mueller, M.J.; Reiber, G.E.; Mehr, D.R.; Madsen, R.W.; Conn, V.S. Effect of weight-bearing activity on foot ulcer incidence in people with diabetic peripheral neuropathy: Feet first randomized controlled trial. Phys. Ther., 2008, 88(11), 1385-1398.
[http://dx.doi.org/10.2522/ptj.20080019] [PMID: 18801859]

Armstrong, D.G.; Lavery, L.A.; Holtz-Neiderer, K.; Mohler, M.J.; Wendel, C.S.; Nixon, B.P.; Boulton, A.J.M. Variability in activity may precede diabetic foot ulceration. Diabetes Care, 2004, 27(8), 1980-1984.
[http://dx.doi.org/10.2337/diacare.27.8.1980] [PMID: 15277427]

Kruse, R.L.; Lemaster, J.W.; Madsen, R.W. Fall and balance outcomes after an intervention to promote leg strength, balance, and walking in people with diabetic peripheral neuropathy: “Feet first” randomized controlled trial. Phys. Ther., 2010, 90(11), 1568-1579.
[http://dx.doi.org/10.2522/ptj.20090362] [PMID: 20798179]

Boor, P.; Celec, P.; Behuliak, M.; Grančič, P.; Kebis, A.; Kukan, M.; Pronayová, N.; Liptaj, T.; Ostendorf, T.; Sebeková, K. Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats. Metabolism, 2009, 58(11), 1669-1677.
[http://dx.doi.org/10.1016/j.metabol.2009.05.025] [PMID: 19608208]

Yoshikawa, T.; Miyazaki, A.; Fujimoto, S. Decrease in serum levels of advanced glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females. Med. Sci. Monit., 2009, 15(6), PH65-PH73.
[PMID: 19478714]

Kotani, K.; Caccavello, R.; Sakane, N.; Yamada, T.; Taniguchi, N.; Gugliucci, A. Influence of physical activity intervention on circulating soluble receptor for advanced glycation end products in elderly subjects. J. Clin. Med. Res., 2011, 3(5), 252-257.
[http://dx.doi.org/10.4021/jocmr704w] [PMID: 22383913]

Balducci, S.; Zanuso, S.; Nicolucci, A.; Fernando, F.; Cavallo, S.; Cardelli, P.; Fallucca, S.; Alessi, E.; Letizia, C.; Jimenez, A.; Fallucca, F.; Pugliese, G. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr. Metab. Cardiovasc. Dis., 2010, 20(8), 608-617.
[http://dx.doi.org/10.1016/j.numecd.2009.04.015] [PMID: 19695853]

Ahn, S.; Song, R. Effects of Tai Chi Exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. J. Altern. Complement. Med., 2012, 18(12), 1172-1178.
[http://dx.doi.org/10.1089/acm.2011.0690] [PMID: 22985218]

Thompson, W. R.; Gordon, N. F.; Gordon, L.S. ACSM’s guidelines for exercise testing and prescriptionacsm’s guidelines for exercise testing and prescription. Philadelphia, USA: Lippincott Williams & Wilkins. 2010.

Hung, J.W.; Liou, C.W.; Wang, P.W.; Yeh, S.H.; Lin, L.W.; Lo, S.K.; Tsai, F.M. Effect of 12-week tai chi chuan exercise on peripheral nerve modulation in patients with type 2 diabetes mellitus. J. Rehabil. Med., 2009, 41(11), 924-929.
[http://dx.doi.org/10.2340/16501977-0445] [PMID: 19841845]

A Report of the Surgeon General.. Physical Activity and Health: A Report of the Surgeon General, 1996. Available from: https://profiles.nlm.nih.gov/spotlight/nn/catalog/nlm:nlmuid-101584932X107-doc (Accessed on Dec 1, 2020).

Johnson, C.E.; Takemoto, J.K. A review of beneficial low-intensity exercises in diabetic peripheral neuropathy patients. J. Pharm. Pharm. Sci., 2019, 22(1), 22-27.
[http://dx.doi.org/10.18433/jpps30151] [PMID: 30599819]

Yoo, M.; D’Silva, L.J.; Martin, K.; Sharma, N.K.; Pasnoor, M.; LeMaster, J.W.; Kluding, P.M. Pilot study of exercise therapy on painful diabetic peripheral neuropathy. Pain Med., 2015, 16(8), 1482-1489.
[http://dx.doi.org/10.1111/pme.12743] [PMID: 25800666]

Kanchanasamut, W.; Pensri, P. Effects of weight-bearing exercise on a mini-trampoline on foot mobility, plantar pressure and sensation of diabetic neuropathic feet; a preliminary study. Diabet. Foot Ankle, 2017, 8(1), 1287239.
[http://dx.doi.org/10.1080/2000625X.2017.1287239] [PMID: 28326159]

Manor, B.; Lipsitz, L.A.; Wayne, P.M.; Peng, C-K.; Li, L. Complexity-based measures inform Tai Chi’s impact on standing postural control in older adults with peripheral neuropathy. BMC Complement. Altern. Med., 2013, 13, 87.
[http://dx.doi.org/10.1186/1472-6882-13-87] [PMID: 23587193]

Herman, W.H.; Pop-Busui, R.; Braffett, B.H.; Martin, C.L.; Cleary, P.A.; Albers, J.W.; Feldman, E.L.; Group, D.R. Use of the michigan neuropathy screening instrument as a measure of distal symmetrical peripheral neuropathy in type 1 diabetes: Results from the diabetes control and complications trial/epidemiology of diabetes interventions and complications. Diabet. Med., 2012, 29(7), 937-944.
[http://dx.doi.org/10.1111/j.1464-5491.2012.03644.x] [PMID: 22417277]

Singleton, J.R.; Marcus, R.L.; Jackson, J.E.; K Lessard, M.; Graham, T.E.; Smith, A.G. Exercise increases cutaneous nerve density in diabetic patients without neuropathy. Ann. Clin. Transl. Neurol., 2014, 1(10), 844-849.
[http://dx.doi.org/10.1002/acn3.125] [PMID: 25493275]

Smith, A.G.; Russell, J.; Feldman, E.L.; Goldstein, J.; Peltier, A.; Smith, S.; Hamwi, J.; Pollari, D.; Bixby, B.; Howard, J.; Singleton, J.R. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care, 2006, 29(6), 1294-1299.
[http://dx.doi.org/10.2337/dc06-0224] [PMID: 16732011]

Kluding, P.M.; Pasnoor, M.; Singh, R.; Jernigan, S.; Farmer, K.; Rucker, J.; Sharma, N.K.; Wright, D.E. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J. Diabetes Complications, 2012, 26(5), 424-429.
[http://dx.doi.org/10.1016/j.jdiacomp.2012.05.007] [PMID: 22717465]

Gómez-Pinilla, F.; Ying, Z.; Opazo, P.; Roy, R.R.; Edgerton, V.R. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. Eur. J. Neurosci., 2001, 13(6), 1078-1084.
[http://dx.doi.org/10.1046/j.0953-816x.2001.01484.x] [PMID: 11285004]

Li, H.; Shen, Z.; Lu, Y.; Lin, F.; Wu, Y.; Jiang, Z. Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats. Mol. Med. Rep., 2012, 6(1), 69-74.
[PMID: 22552353]

Shankarappa, S.A.; Piedras-Rentería, E.S.; Stubbs, E.B., Jr Forced-exercise delays neuropathic pain in experimental diabetes: Effects on voltage-activated calcium channels. J. Neurochem., 2011, 118(2), 224-236.
[http://dx.doi.org/10.1111/j.1471-4159.2011.07302.x] [PMID: 21554321]

Bement, M.K.H.; Sluka, K.A. Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner. Arch. Phys. Med. Rehabil., 2005, 86(9), 1736-1740.
[http://dx.doi.org/10.1016/j.apmr.2005.03.029] [PMID: 16181935]

Sluka, K.A.; O’Donnell, J.M.; Danielson, J.; Rasmussen, L.A. Regular physical activity prevents development of chronic pain and activation of central neurons. J Appl Physiol (1985), 2013, 114(6), 725-733.
[http://dx.doi.org/10.1152/japplphysiol.01317.2012] [PMID: 23271699]

Atalay, M.; Oksala, N.K.J.; Laaksonen, D.E.; Khanna, S.; Nakao, C.; Lappalainen, J.; Roy, S.; Hänninen, O.; Sen, C.K. Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol (1985), 2004, 97(2), 605-611.
[http://dx.doi.org/10.1152/japplphysiol.01183.2003] [PMID: 15075301]

Chen, Y-W.; Hsieh, P-L.; Chen, Y-C.; Hung, C-H.; Cheng, J-T. Physical exercise induces excess hsp72 expression and delays the development of hyperalgesia and allodynia in painful diabetic neuropathy rats. Anesth. Analg., 2013, 116(2), 482-490.
[http://dx.doi.org/10.1213/ANE.0b013e318274e4a0] [PMID: 23302966]

Ogata, T.; Oishi, Y.; Higashida, K.; Higuchi, M.; Muraoka, I. Prolonged exercise training induces long-term enhancement of HSP70 expression in rat plantaris muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009, 296(5), R1557-R1563.
[http://dx.doi.org/10.1152/ajpregu.90911.2008] [PMID: 19244585]

Lee, S.J.; Zhang, G.F.; Sung, N.J. Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. Nutr. Res. Pract., 2011, 5(4), 301-307.
[http://dx.doi.org/10.4162/nrp.2011.5.4.301] [PMID: 21994524]

Grover, J.K.; Vats, V.; Rathi, S.S.; Dawar, R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J. Ethnopharmacol., 2001, 76(3), 233-238.
[http://dx.doi.org/10.1016/S0378-8741(01)00246-X] [PMID: 11448544]

Wang, J.; van der Heijden, R.; Spruit, S.; Hankermeier, T.; Chan, K.; van der Greef, J.; Xu, G.; Wang, M. Quality and safety of Chinese herbal medicines guided by a systems biology perspective. J. Ethnopharmacol., 2009, 126(1), 31-41.
[http://dx.doi.org/10.1016/j.jep.2009.07.040] [PMID: 19683045]

Ferreira, P.E.B.; Lopes, C.R.P.; Alves, A.M.P.; Alves, É.P.B.; Linden, D.R.; Zanoni, J.N.; Buttow, N.C. Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats. World J. Gastroenterol., 2013, 19(38), 6416-6426.
[http://dx.doi.org/10.3748/wjg.v19.i38.6416] [PMID: 24151360]

D’Andrea, G. Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia, 2015, 106, 256-271.
[http://dx.doi.org/10.1016/j.fitote.2015.09.018] [PMID: 26393898]

Bravo, L. Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev., 1998, 56(11), 317-333.
[http://dx.doi.org/10.1111/j.1753-4887.1998.tb01670.x] [PMID: 9838798]

Ganeshpurkar, A.; Saluja, A.K. The pharmacological potential of rutin. Saudi Pharm. J., 2017, 25(2), 149-164.
[http://dx.doi.org/10.1016/j.jsps.2016.04.025] [PMID: 28344465]

Hosseinzadeh, H.; Nassiri-Asl, M. Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid. J. Endocrinol. Invest., 2014, 37(9), 783-788.
[http://dx.doi.org/10.1007/s40618-014-0096-3] [PMID: 24879037]

Tian, R.; Yang, W.; Xue, Q.; Gao, L.; Huo, J.; Ren, D.; Chen, X. Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats. Eur. J. Pharmacol., 2016, 771, 84-92.
[http://dx.doi.org/10.1016/j.ejphar.2015.12.021] [PMID: 26688570]

Al-Enazi, M.M. Protective effects of combined therapy of rutin with silymarin on experimentally-induced diabetic neuropathy in rats. pharmacol. &amp Pharm., 2014, 05, 876-889.

Sato, Y.; Itagaki, S.; Kurokawa, T.; Ogura, J.; Kobayashi, M.; Hirano, T.; Sugawara, M.; Iseki, K. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int. J. Pharm., 2011, 403(1-2), 136-138.
[http://dx.doi.org/10.1016/j.ijpharm.2010.09.035] [PMID: 20933071]

dos Santos, M.D.; Almeida, M.C.; Lopes, N.P.; de Souza, G.E.P. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol. Pharm. Bull., 2006, 29(11), 2236-2240.
[http://dx.doi.org/10.1248/bpb.29.2236] [PMID: 17077520]

Abraham, S.K.; Schupp, N.; Schmid, U.; Stopper, H. Antigenotoxic effects of the phytoestrogen pelargonidin chloride and the polyphenol chlorogenic acid. Mol. Nutr. Food Res., 2007, 51(7), 880-887.
[http://dx.doi.org/10.1002/mnfr.200600214] [PMID: 17579891]

Weng, C-J.; Yen, G-C. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat. Rev., 2012, 38(1), 76-87.
[http://dx.doi.org/10.1016/j.ctrv.2011.03.001] [PMID: 21481535]

Bagdas, D.; Cinkilic, N.; Ozboluk, H.Y.; Ozyigit, M.O.; Gurun, M.S. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. J. Nat. Med., 2013, 67(4), 698-704.
[http://dx.doi.org/10.1007/s11418-012-0726-z] [PMID: 23203628]

Naveed, M.; Hejazi, V.; Abbas, M.; Kamboh, A.A.; Khan, G.J.; Shumzaid, M.; Ahmad, F.; Babazadeh, D.; FangFang, X.; Modarresi-Ghazani, F.; WenHua, L.; XiaoHui, Z. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed. Pharmacother., 2018, 97, 67-74.
[http://dx.doi.org/10.1016/j.biopha.2017.10.064] [PMID: 29080460]

Nangle, M.R.; Gibson, T.M.; Cotter, M.A.; Cameron, N.E. Effects of eugenol on nerve and vascular dysfunction in streptozotocin-diabetic rats. Planta Med., 2006, 72(6), 494-500.
[http://dx.doi.org/10.1055/s-2005-916262] [PMID: 16773532]

Mohammadi Nejad, S.; Özgüneş, H.; Başaran, N. Öjenolün Farmakolojik Ve Toksikolojik Özellikleri. Turkish J. Pharm. Sci., 2017, 14, 201-206.
[http://dx.doi.org/10.4274/tjps.62207]

Lopresti, A.L.; Hood, S.D.; Drummond, P.D. Multiple antidepressant potential modes of action of curcumin: A review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. J. Psychopharmacol., 2012, 26(12), 1512-1524.
[http://dx.doi.org/10.1177/0269881112458732] [PMID: 23035031]

Banafshe, H.R.; Hamidi, G.A.; Noureddini, M.; Mirhashemi, S.M.; Mokhtari, R.; Shoferpour, M. Effect of curcumin on diabetic peripheral neuropathic pain: Possible involvement of opioid system. Eur. J. Pharmacol., 2014, 723, 202-206.
[http://dx.doi.org/10.1016/j.ejphar.2013.11.033] [PMID: 24315931]

Kocaadam, B.; Şanlier, N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr., 2017, 57(13), 2889-2895.
[http://dx.doi.org/10.1080/10408398.2015.1077195] [PMID: 26528921]

Biesbroeck, R.; Bril, V.; Hollander, P.; Kabadi, U.; Schwartz, S.; Singh, S.P.; Ward, W.K.; Bernstein, J.E. A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy. Adv. Ther., 1995, 12(2), 111-120.
[PMID: 10150323]

The Capsaicin Study Group. Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle- controlled study. Arch. Intern. Med., 1991, 151(11), 2225-2229.
[http://dx.doi.org/10.1001/archinte.1991.00400110079017] [PMID: 1953227]

Srinivasan, K. Biological activities of red pepper (capsicum annuum) and its pungent principle capsaicin: A review. Crit. Rev. Food Sci. Nutr., 2016, 56(9), 1488-1500.
[http://dx.doi.org/10.1080/10408398.2013.772090] [PMID: 25675368]

Uzar, E.; Alp, H.; Cevik, M.U.; Fırat, U.; Evliyaoglu, O.; Tufek, A.; Altun, Y. Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats. Neurol. Sci., 2012, 33(3), 567-574.
[http://dx.doi.org/10.1007/s10072-011-0775-1] [PMID: 21922312]

Kandhare, A.D.; Raygude, K.S.; Ghosh, P.; Ghule, A.E.; Bodhankar, S.L. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia, 2012, 83(4), 650-659.
[http://dx.doi.org/10.1016/j.fitote.2012.01.010] [PMID: 22343014]

Wu, J.; Zhang, X.; Zhang, B. Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials. J. Tradit. Chin. Med., 2014, 34(4), 401-410.
[http://dx.doi.org/10.1016/S0254-6272(15)30039-X] [PMID: 25185357]

Visnagri, A.; Kandhare, A.D.; Chakravarty, S.; Ghosh, P.; Bodhankar, S.L. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm. Biol., 2014, 52(7), 814-828.
[http://dx.doi.org/10.3109/13880209.2013.870584] [PMID: 24559476]

Ibrahimpasic, K. Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med. Arh., 2013, 67(1), 7-9.
[http://dx.doi.org/10.5455/medarh.2013.67.7-9] [PMID: 23678828]

Horrobin, D.F. The use of gamma-linolenic acid in diabetic neuropathy. Agents Actions Suppl., 1992, 37, 120-144.
[http://dx.doi.org/10.1007/978-3-0348-7262-1_18] [PMID: 1321553]

Ghatak, S.B.; Panchal, S.S. Protective effect of oryzanol isolated from crude rice bran oil in experimental model of diabetic neuropathy. Rev. Bras. Farmacogn., 2012, 22, 1092-1103.
[http://dx.doi.org/10.1590/S0102-695X2012005000104]

Liu, Y.; Wang, L.; Li, X.; Lv, C.; Feng, D.; Luo, Z. Tanshinone IIA improves impaired nerve functions in experimental diabetic rats. Biochem. Biophys. Res. Commun., 2010, 399(1), 49-54.
[http://dx.doi.org/10.1016/j.bbrc.2010.07.037] [PMID: 20637731]

Packer, L.; Witt, E.H.; Tritschler, H.J. alpha-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med., 1995, 19(2), 227-250.
[http://dx.doi.org/10.1016/0891-5849(95)00017-R] [PMID: 7649494]

Nagamatsu, M.; Nickander, K.K.; Schmelzer, J.D.; Raya, A.; Wittrock, D.A.; Tritschler, H.; Low, P.A. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care, 1995, 18(8), 1160-1167.
[http://dx.doi.org/10.2337/diacare.18.8.1160] [PMID: 7587852]

Low, P.A.; Nickander, K.K.; Tritschler, H.J. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes, 1997, 46(Suppl. 2), S38-S42.
[http://dx.doi.org/10.2337/diab.46.2.S38] [PMID: 9285497]

Papanas, N.; Ziegler, D. Efficacy of α-lipoic acid in diabetic neuropathy. Expert Opin. Pharmacother., 2014, 15(18), 2721-2731.
[http://dx.doi.org/10.1517/14656566.2014.972935] [PMID: 25381809]

Inan, S. The potential role of nutraceuticals in inflammation and oxidative stress. In: Nutraceuticals - past, present and future; María Chávarri, Hueda, Ed.; IntechOpen, 2020.
[http://dx.doi.org/10.5772/intechopen.83797]

Shahidi, F.; Ambigaipalan, P. Omega-3 polyunsaturated fatty acids and their health benefits. Annu. Rev. Food Sci. Technol., 2018, 9, 345-381.
[http://dx.doi.org/10.1146/annurev-food-111317-095850] [PMID: 29350557]

Mittal, J.; Sharma, M.M.; Batra, A. Tinospora cordifolia: A multipurpose medicinal plant-a review. J. Med. Plants Stud., 2014, 2(2), 32-47.

Nadig, P.D.; Revankar, R.R.; Dethe, S.M.; Narayanswamy, S.B.; Aliyar, M.A. Effect of Tinospora cordifolia on experimental diabetic neuropathy. Indian J. Pharmacol., 2012, 44(5), 580-583.
[http://dx.doi.org/10.4103/0253-7613.100380] [PMID: 23112417]

Comelli, F.; Bettoni, I.; Colleoni, M.; Giagnoni, G.; Costa, B. Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress. Phytother. Res., 2009, 23(12), 1678-1684.
[http://dx.doi.org/10.1002/ptr.2806] [PMID: 19441010]

Andreae, M.H.; Carter, G.M.; Shaparin, N.; Suslov, K.; Ellis, R.J.; Ware, M.A.; Abrams, D.I.; Prasad, H.; Wilsey, B.; Indyk, D.; Johnson, M.; Sacks, H.S. Inhaled cannabis for chronic neuropathic pain: A meta-analysis of individual patient data. J. Pain, 2015, 16(12), 1221-1232.
[http://dx.doi.org/10.1016/j.jpain.2015.07.009] [PMID: 26362106]

Modesto-Lowe, V.; Bojka, R.; Alvarado, C. Cannabis for peripheral neuropathy: The good, the bad, and the unknown. Cleve. Clin. J. Med., 2018, 85(12), 943-949.
[http://dx.doi.org/10.3949/ccjm.85a.17115] [PMID: 30526755]

Vos, T.; Abajobir, A.A.; Abbafati, C.; Abbas, K.M.; Abate, K.H.; Abd-Allah, F.; Abdulle, A.M.; Abebo, T.A.; Abera, S.F.; Aboyans, V.; Abu-Raddad, L.J.; Ackerman, I.N.; Adamu, A.A.; Adetokunboh, O.; Afarideh, M.; Afshin, A.; Agarwal, S.K.; Aggarwal, R.; Agrawal, A.; Agrawal, S.; Ahmad Kiadaliri, A.; Ahmadieh, H.; Ahmed, M.B.; Aichour, A.N.; Aichour, I.; Aichour, M.T.E.; Aiyar, S.; Akinyemi, R.O.; Akseer, N.; Al Lami, F.H.; Alahdab, F.; Al-Aly, Z.; Alam, K.; Alam, N.; Alam, T.; Alasfoor, D.; Alene, K.A.; Ali, R.; Alizadeh-Navaei, R.; Alkerwi, A.; Alla, F.; Allebeck, P.; Allen, C.; Al-Maskari, F.; Al-Raddadi, R.; Alsharif, U.; Alsowaidi, S.; Altirkawi, K.A.; Amare, A.T.; Amini, E.; Ammar, W.; Amoako, Y.A.; Andersen, H.H.; Antonio, C.A.T.; Anwari, P.; Ärnlöv, J.; Artaman, A.; Aryal, K.K.; Asayesh, H.; Asgedom, S.W.; Assadi, R.; Atey, T.M.; Atnafu, N.T.; Atre, S.R.; Avila-Burgos, L.; Avokpaho, E.F.G.A.; Awasthi, A.; Ayala Quintanilla, B.P.; Ba Saleem, H.O.; Bacha, U.; Badawi, A.; Balakrishnan, K.; Banerjee, A.; Bannick, M.S.; Barac, A.; Barber, R.M.; Barker- Collo, S.L.; Bärnighausen, T.; Barquera, S.; Barregard, L.; Barrero, L.H.; Basu, S.; Battista, B.; Battle, K.E.; Baune, B.T.; Bazargan-Hejazi, S.; Beardsley, J.; Bedi, N.; Beghi, E.; Béjot, Y.; Bekele, B.B.; Bell, M.L.; Bennett, D.A.; Bensenor, I.M.; Benson, J.; Berhane, A.; Berhe, D.F.; Bernabé, E.; Betsu, B.D.; Beuran, M.; Beyene, A.S.; Bhala, N.; Bhansali, A.; Bhatt, S.; Bhutta, Z.A.; Biadgilign, S.; Bienhoff, K.; Bikbov, B.; Birungi, C.; Biryukov, S.; Bisanzio, D.; Bizuayehu, H.M.; Boneya, D.J.; Boufous, S.; Bourne, R.R.A.; Brazinova, A.; Brugha, T.S.; Buchbinder, R.; Bulto, L.N.B.; Bumgarner, B.R.; Butt, Z.A.; Cahuana-Hurtado, L.; Cameron, E.; Car, M.; Carabin, H.; Carapetis, J.R.; Cárdenas, R.; Carpenter, D.O.; Carrero, J.J.; Carter, A.; Carvalho, F.; Casey, D.C.; Caso, V.; Castañeda-Orjuela, C.A.; Castle, C.D.; Catalá-López, F.; Chang, H.Y.; Chang, J.C.; Charlson, F.J.; Chen, H.; Chibalabala, M.; Chibueze, C.E.; Chisumpa, V.H.; Chitheer, A.A.; Christopher, D.J.; Ciobanu, L.G.; Cirillo, M.; Colombara, D.; Cooper, C.; Cortesi, P.A.; Criqui, M.H.; Crump, J.A.; Dadi, A.F.; Dalal, K.; Dandona, L.; Dandona, R.; Das Neves, J.; Davitoiu, D.V.; De Courten, B.; De Leo, D.; Degenhardt, L.; Deiparine, S.; Dellavalle, R.P.; Deribe, K.; Des Jarlais, D.C.; Dey, S.; Dharmaratne, S.D.; Dhillon, P.K.; Dicker, D.; Ding, E.L.; Djalalinia, S.; Do, H.P.; Dorsey, E.R.; Dos Santos, K.P.B.; Douwes-Schultz, D.; Doyle, K.E.; Driscoll, T.R.; Dubey, M.; Duncan, B.B.; El-Khatib, Z.Z.; Ellerstrand, J.; Enayati, A.; Endries, A.Y.; Ermakov, S.P.; Erskine, H.E.; Eshrati, B.; Eskandarieh, S.; Esteghamati, A.; Estep, K.; Fanuel, F.B.B.; Farinha, C.S.E.S.; Faro, A.; Farzadfar, F.; Fazeli, M.S.; Feigin, V.L.; Fereshtehnejad, S.M.; Fernandes, J.C.; Ferrari, A.J.; Feyissa, T.R.; Filip, I.; Fischer, F.; Fitzmaurice, C.; Flaxman, A.D.; Flor, L.S.; Foigt, N.; Foreman, K.J.; Franklin, R.C.; Fullman, N.; Fürst, T.; Furtado, J.M.; Futran, N.D.; Gakidou, E.; Ganji, M.; Garcia-Basteiro, A.L.; Gebre, T.; Gebrehiwot, T.T.; Geleto, A.; Gemechu, B.L.; Gesesew, H.A.; Gething, P.W.; Ghajar, A.; Gibney, K.B.; Gill, P.S.; Gillum, R.F.; Ginawi, I.A.M.; Giref, A.Z.; Gishu, M.D.; Giussani, G.; Godwin, W.W.; Gold, A.L.; Goldberg, E.M.; Gona, P.N.; Goodridge, A.; Gopalani, S.V.; Goto, A.; Goulart, A.C.; Griswold, M.; Gugnani, H.C.; Gupta, R.; Gupta, R.; Gupta, T.; Gupta, V.; Hafezi-Nejad, N.; Hailu, A.D.; Hailu, G.B.; Hamadeh, R.R.; Hamidi, S.; Handal, A.J.; Hankey, G.J.; Hao, Y.; Harb, H.L.; Hareri, H.A.; Haro, J.M.; Harvey, J.; Hassanvand, M.S.; Havmoeller, R.; Hawley, C.; Hay, R.J.; Hay, S.I.; Henry, N.J.; Heredia-Pi, I.B.; Heydarpour, P.; Hoek, H.W.; Hoffman, H.J.; Horita, N.; Hosgood, H.D.; Hostiuc, S.; Hotez, P.J.; Hoy, D.G.; Htet, A.S.; Hu, G.; Huang, H.; Huynh, C.; Iburg, K.M.; Igumbor, E.U.; Ikeda, C.; Irvine, C.M.S.; Jacobsen, K.H.; Jahanmehr, N.; Jakovljevic, M.B.; Jassal, S.K.; Javanbakht, M.; Jayaraman, S.P.; Jeemon, P.; Jensen, P.N.; Jha, V.; Jiang, G.; John, D.; Johnson, C.O.; Johnson, S.C.; Jonas, J.B.; Jürisson, M.; Kabir, Z.; Kadel, R.; Kahsay, A.; Kamal, R.; Kan, H.; Karam, N.E.; Karch, A.; Karema, C.K.; Kasaeian, A.; Kassa, G.M.; Kassaw, N.A.; Kassebaum, N.J.; Kastor, A.; Katikireddi, S.V.; Kaul, A.; Kawakami, N.; Keiyoro, P.N.; Kengne, A.P.; Keren, A.; Khader, Y.S.; Khalil, I.A.; Khan, E.A.; Khang, Y.H.; Khosravi, A.; Khubchandani, J.; Kieling, C.; Kim, D.; Kim, P.; Kim, Y.J.; Kimokoti, R.W.; Kinfu, Y.; Kisa, A.; Kissimova-Skarbek, K.A.; Kivimaki, M.; Knudsen, A.K.; Kokubo, Y.; Kolte, D.; Kopec, J.A.; Kosen, S.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.; Krishnaswami, S.; Krohn, K.J.; Defo, K. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the global burden of disease study 2016. Lancet, 2017, 390, 1211-1259.
[http://dx.doi.org/10.1016/S0140-6736(17)32154-2]

Kim, J.; Yokoyama, K.; Araki, S. The effects of Ginkgo biloba extract (GBe) on axonal transport microvasculature and morphology of sciatic nerve in streptozotocin-induced diabetic rats. Environ. Health Prev. Med., 2000, 5(2), 53-59.
[http://dx.doi.org/10.1007/BF02932004] [PMID: 21432198]

Bhanot, A.; Shri, R. A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice. Pharmacognosy Res., 2010, 2(6), 374-384.
[http://dx.doi.org/10.4103/0974-8490.75460] [PMID: 21713142]

Rocha-González, H.I.; Ramírez-Aguilar, M.; Granados-Soto, V.; Reyes-García, J.G.; Torres-López, J.E.; Huerta-Cruz, J.C.; Navarrete, A. Antineuropathic effect of 7-hydroxy-3,4-dihydrocadalin in streptozotocin-induced diabetic rodents. BMC Complement. Altern. Med., 2014, 14, 129.
[http://dx.doi.org/10.1186/1472-6882-14-129] [PMID: 24708659]

Yadav, S.K.; Nagori, B.P.; Desai, P.K. Pharmacological characterization of different fractions of Calotropis procera (Asclepiadaceae) in streptozotocin induced experimental model of diabetic neuropathy. J. Ethnopharmacol., 2014, 152(2), 349-357.
[http://dx.doi.org/10.1016/j.jep.2014.01.020] [PMID: 24486599]

Moghadam, F.H.; Vakili-Zarch, B.; Shafiee, M.; Mirjalili, A. Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice. EXCLI J., 2013, 12, 282-290.
[PMID: 26417231]

Raafat, K.; Samy, W. Amelioration of diabetes and painful diabetic neuropathy by punica granatum l. extract and its spray dried biopolymeric dispersions. Evid. Based Complement. Alternat. Med., 2014, 2014, 180495.
[http://dx.doi.org/10.1155/2014/180495] [PMID: 24982685]

Tiwari, V.; Kuhad, A.; Chopra, K. Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade. Phytother. Res., 2011, 25(10), 1527-1536.
[http://dx.doi.org/10.1002/ptr.3440] [PMID: 21394805]

Ravi, K.; Ramachandran, B.; Subramanian, S. Effect of Eugenia Jambolana seed kernel on antioxidant defense system in streptozotocin-induced diabetes in rats. Life Sci., 2004, 75(22), 2717-2731.
[http://dx.doi.org/10.1016/j.lfs.2004.08.005] [PMID: 15369706]

Kedar, P.; Chakrabarti, C.H. Effects of jambolan seed treatment on blood sugar, lipids and urea in streptozotocin induced diabetes in rabbits. Indian J. Physiol. Pharmacol., 1983, 27(2), 135-140.
[PMID: 6885126]

Li, X.L.; Li, B.Y.; Gao, H.Q.; Cheng, M.; Xu, L.; Li, X.H.; Ma, Y.B. Effects of grape seed proanthocyanidin extracts on aortic pulse wave velocity in streptozocin induced diabetic rats. Biosci. Biotechnol. Biochem., 2009, 73(6), 1348-1354.
[http://dx.doi.org/10.1271/bbb.90008] [PMID: 19502731]

Sindrup, S.H.; Madsen, C.; Bach, F.W.; Gram, L.F.; Jensen, T.S.St. St. John’s wort has no effect on pain in polyneuropathy. Pain, 2001, 91(3), 361-365.
[http://dx.doi.org/10.1016/S0304-3959(00)00457-7] [PMID: 11275394]

Zhang, Q.; Ji, L.; Zheng, H.; Li, Q.; Xiong, Q.; Sun, W.; Zhu, X.; Li, Y.; Lu, B.; Liu, X.; Zhang, S. Low serum phosphate and magnesium levels are associated with peripheral neuropathy in patients with type 2 diabetes mellitus. Diabetes Res. Clin. Pract., 2018, 146, 1-7.
[http://dx.doi.org/10.1016/j.diabres.2018.09.015] [PMID: 30273706]

De Leeuw, I.; Engelen, W.; De Block, C.; Van Gaal, L. Long term magnesium supplementation influences favourably the natural evolution of neuropathy in Mg-depleted type 1 diabetic patients (T1dm). Magnes. Res., 2004, 17(2), 109-114.
[PMID: 15319143]

Tütüncü, N.B.; Bayraktar, M.; Varli, K. Reversal of defective nerve conduction with vitamin E supplementation in type 2 diabetes: A preliminary study. Diabetes Care, 1998, 21(11), 1915-1918.
[http://dx.doi.org/10.2337/diacare.21.11.1915] [PMID: 9802743]

Niafar, M.; Hai, F.; Porhomayon, J.; Nader, N.D. The role of metformin on vitamin b12 deficiency: A meta-analysis review. Intern. Emerg. Med., 2015, 10(1), 93-102.
[PMID: 25502588]

Sil, A.; Kumar, H.; Mondal, R.D.; Anand, S.S.; Ghosal, A.; Datta, A.; Sawant, S.V.; Kapatkar, V.; Kadhe, G.; Rao, S. A randomized, open labeled study comparing the serum levels of cobalamin after three doses of 500 mcg vs. a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy. Korean J. Pain, 2018, 31(3), 183-190.
[http://dx.doi.org/10.3344/kjp.2018.31.3.183] [PMID: 30013732]

Jayabalan, B.; Low, L.L.; Vitamin, B. Vitamin B supplementation for diabetic peripheral neuropathy. Singapore Med. J., 2016, 57(2), 55-59.
[http://dx.doi.org/10.11622/smedj.2016027] [PMID: 26892473]

Jiang, D.Q.; Li, M.X.; Wang, Y.; Wang, Y. Effects of prostaglandin E1 plus methylcobalamin alone and in combination with lipoic acid on nerve conduction velocity in patients with diabetic peripheral neuropathy: A meta-analysis. Neurosci. Lett., 2015, 594, 23-29.
[http://dx.doi.org/10.1016/j.neulet.2015.03.037] [PMID: 25800109]

Xu, Q.; Pan, J.; Yu, J.; Liu, X.; Liu, L.; Zuo, X.; Wu, P.; Deng, H.; Zhang, J.; Ji, A. Meta-analysis of methylcobalamin alone and in combination with lipoic acid in patients with diabetic peripheral neuropathy. Diabetes Res. Clin. Pract., 2013, 101(2), 99-105.
[http://dx.doi.org/10.1016/j.diabres.2013.03.033] [PMID: 23664235]

Fonseca, V.A.; Lavery, L.A.; Thethi, T.K.; Daoud, Y.; DeSouza, C.; Ovalle, F.; Denham, D.S.; Bottiglieri, T.; Sheehan, P.; Rosenstock, J. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am. J. Med., 2013, 126(2), 141-149.
[http://dx.doi.org/10.1016/j.amjmed.2012.06.022] [PMID: 23218892]

Mottaghi, T.; Khorvash, F.; Maracy, M.; Bellissimo, N.; Askari, G. Effect of folic acid supplementation on nerve conduction velocity in diabetic polyneuropathy patients. Neurol. Res., 2019, 41(4), 364-368.
[http://dx.doi.org/10.1080/01616412.2019.1565180] [PMID: 30730785]

Lee, P.; Chen, R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch. Intern. Med., 2008, 168(7), 771-772.
[http://dx.doi.org/10.1001/archinte.168.7.771] [PMID: 18413561]

Shehab, D.; Al-Jarallah, K.; Abdella, N.; Mojiminiyi, O.A.; Al Mohamedy, H. Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med. Princ. Pract., 2015, 24(3), 250-256.
[http://dx.doi.org/10.1159/000375304] [PMID: 25720672]

Baute, V.; Zelnik, D.; Curtis, J.; Sadeghifar, F. Complementary and alternative medicine for painful peripheral neuropathy. Curr. Treat. Options Neurol., 2019, 21(9), 44.
[http://dx.doi.org/10.1007/s11940-019-0584-z] [PMID: 31478093]

Ghadiri-Anari, A.; Mozafari, Z.; Gholami, S.; Khodaei, S.A.; Aboutorabi-Zarchi, M.; Sepehri, F.; Nadjarzade, A.; Rahmanian, M.; Namiranian, N. Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial. Diabetes Metab. Syndr., 2019, 13(1), 890-893.
[http://dx.doi.org/10.1016/j.dsx.2018.12.014] [PMID: 30641826]