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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Bioactive Molecules from the Alpinia Genus: A Comprehensive Review

Author(s): Santwona Dash, Manasa K. Panda, Mayanglambam C. Singh, Bimal P. Jit, Yengkhom D. Singh* and Jayanta K. Patra*

Volume 21, Issue 14, 2020

Page: [1412 - 1421] Pages: 10

DOI: 10.2174/1389201021666200510002409

Price: $65

Abstract

Background: Floral has diversity and unique nature due to the complex structure and component. Alpinia is an important genus of the Zingiberaceae family having complex taxonomical diversity. The presence of many unique bioactive molecules makes this genus, a pharmaceutically important genus. They provide a wide range of medicinal properties, including traditional remedies to modern therapeutic applications.

Methods: Extracts of Alpinia mostly contain bioactive molecules and secondary metabolites such as polyphenolics, tannins, flavonoids and other therapeutically important compounds. These bioactive molecules are biologically active, treating against inflammation, cancer, arterial hypertension, and other deadly diseases.

Results: These bioactive molecules can act as natural enzyme inhibitors for some of the deadly diseases and can block the pathway for metabolic activities. In addition, these genera have played a major role in multidisciplinary studies of phytochemistry, ethnobotany, and pharmacological aspects in day-to-day life.

Conclusion: Therefore, this review highlights the fewer known facts of the genus Alpinia in terms of bioactive molecules and its significant therapeutic applications to help in combating major diseases of humans.

Keywords: Alpinia, anti-inflammatory, anti-oxidant, bioactive molecules, cancer, diabetic, phytochemistry, neurological diseases.

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[1]
Chouni, A.; Paul, S. a review on phytochemical and pharmacological potential of Alpinia galanga. Pharmacogn. J., 2018, 10(1), 9-15.
[http://dx.doi.org/10.5530/pj.2018.1.2]
[2]
Unnisa, A.; Parven, T.D. Anti-inflammatory and acute toxicity studies of the extracts from the rhizomes of Alpinia galangal Willd. Pharm. Sin., 2011, 2(2), 361-367.
[3]
Kaliyadasa, E.; Samarasinghe, B.A. Genus alpinia, a potential powerhouse of bioactive: A review. Int. J. Pharm. Sci. Res., 2019, 10(6), 2644-2653.
[4]
Verma, R.K.; Garima, M.; Pradeep, S.; Jha, K.K.; Khosa, R.L. Alpinia galanga-an important medicinal plant: A review. Pharm. Sin., 2011, 2(1), 142-154.
[5]
Vanwyk, B.E.; Wink, M. Medicinal plant of the world, 1st ed; Briz Publication: South Africa, 2009.
[6]
Patel, B.V. A Report of The Seminar on, Herbal Drugs: Present Status and Future Prospects; Perd Centre: Ahmedabad, 2001.
[7]
Ghosh, S.; Rangan, L. Alpinia: The gold mine of future therapeutics. 3 Biotech, 2013, 3(3), 173-185.
[8]
Paul, T.; Devasagayam, A. Radiation Biology and Health Sciences Division; Bhabha Atomic Research Centre: Mumbai, 2006.
[9]
Jain, J.B.; Kumane, S.C.; Bhattacharya, S. Medicinal flora of Madhya Pradesh and Chattisgarh-a review. Indian J. Tradit. Knowl., 2006, 5(2), 237-242.
[10]
World Health Organization Research guidelines for evaluating the safety and efficacy of herbal medicines; WHO Regional Office for the Western Pacific: Manila, 1993.
[11]
Victório, C.P. Therapeutic value of the genus Alpinia, Zingiberaceae. Rev. Bras. Farmacogn., 2011, 21(1), 194-201.
[http://dx.doi.org/10.1590/S0102-695X2011005000025]
[12]
Fabricant, D.S.; Farnsworth, N.R. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect., 2001, 109(Suppl. 1), 69-75.
[PMID: 11250806]
[13]
Victório, C.P.; Lage, C.L.S. Uso de plantas medicinais. Revista Arquivos FOG-Saúde, Sociedade. Gestão e Meio Ambiente, 2008, 5(1), 33-41.
[14]
Gurib-Fakim, A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol. Aspects Med., 2006, 27(1), 1-93.
[http://dx.doi.org/10.1016/j.mam.2005.07.008] [PMID: 16105678]
[15]
Sharifi-Rad, J.; Salehi, B.; Varoni, E.M.; Sharopov, F.; Yousaf, Z.; Ayatollahi, S.A.; Kobarfard, F.; Sharifi-Rad, M.; Afdjei, M.H.; Sharifi-Rad, M.; Iriti, M. Plants of the Melaleuca genus as antimicrobial agents: From farm to pharmacy. Phytother. Res., 2017, 31(10), 1475-1494.
[http://dx.doi.org/10.1002/ptr.5880] [PMID: 28782167]
[16]
Burt, S. Essential oils: Their antibacterial properties and potential applications in foods-a review. Int. J. Food Microbiol., 2004, 94(3), 223-253.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2004.03.022] [PMID: 15246235]
[17]
Tajkarimi, M.M.; Ibrahim, S.A.; Cliver, D.O. Antimicrobial herb and spice compounds in food. Food Control, 2010, 21(9), 1199-1218.
[http://dx.doi.org/10.1016/j.foodcont.2010.02.003]
[18]
Sharifi-Rad, J.; Soufi, L.; Ayatollahi, S.A.M.; Iriti, M.; Sharifi-Rad, M.; Varoni, E.M.; Shahri, F.; Esposito, S.; Kuhestani, K.; Sharifi-Rad, M. Anti-bacterial effect of essential oil from Xanthium strumarium against shiga toxin-producing Escherichia coli. Cell. Mol. Biol., 2016, 62(9), 69-74.
[PMID: 27650979]
[19]
Sharifi-Rad, M.; Varoni, E.M.; Salehi, B.; Sharifi-Rad, J.; Matthews, K.R.; Ayatollahi, S.A.; Kobarfard, F.; Ibrahim, S.A.; Mnayer, D.; Zakaria, Z.A.; Sharifi-Rad, M.; Yousaf, Z.; Iriti, M.; Basile, A.; Rigano, D. Plants of the genus Zingiber as a source of bioactive phytochemicals: From tradition to pharmacy. Molecules, 2017, 22(12), 2145.
[http://dx.doi.org/10.3390/molecules22122145] [PMID: 29207520]
[20]
Rimondini, L.; Varoni, E. Essential oil from berries of Lebanese Juniperusexcelsa M. Bieb displays similar antibacterial activity to chlorhexidine but higher cytocompatibility with human oral primary cells. Molecules, 2015, 20(5), 9344-9357. [20-a Amadi, S.W.; Zhang, Y.; Wu, G. Research progress in phytochemistry and biology of Aframomum species. Pharm. Biol., 2016, 54(11), 2761-2770.
[PMID: 27159353]
[21]
Kress, W.J.; Liu, A.Z.; Newman, M.; Li, Q.J. The molecular phylogeny of Alpinia (Zingiberaceae): A complex and polyphyletic genus of gingers. Am. J. Bot., 2005, 92(1), 167-178.
[http://dx.doi.org/10.3732/ajb.92.1.167] [PMID: 21652395]
[22]
Tomlinson, P.B. Anatomy of the monocotyledons. III, Commelinales-zingiberales. Oxford: Clarendon press; , 1969.
[23]
Pancharoen, O.; Prawat, U.; Tuntiwachwuttikul, P. Phytochemistry of the zingiberaceae. Studies Nat. Products Chem., 2000, 23, 797-865.
[http://dx.doi.org/10.1016/S1572-5995(00)80142-8]
[24]
Leal-Cardoso, J.H.; Moreira, M.R.; da Cruz, G.M.; de Morais, S.M.; Lahlou, M.S.; Coelho-de-Souza, A.N. Effects of essential oil of Alpinia zerumbet on the compound action potential of the rat sciatic nerve. Phytomedicine, 2004, 11(6), 549-553.
[http://dx.doi.org/10.1016/j.phymed.2003.07.008] [PMID: 15500268]
[25]
Sirirugsa, P. Thai Zingiberaceae: Species diversity and their uses. Pure Appl. Chem., 1999, 70, 1-8.
[26]
Chien, S.T.; Shi, M.D.; Lee, Y.C.; Te, C.C.; Shih, Y.W. Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells. Cancer Cell Int., 2015, 15(1), 15.
[http://dx.doi.org/10.1186/s12935-015-0168-2] [PMID: 25698902]
[27]
Thirumurugan, D.; Cholarajan, A.; Raja, S.S.; Vijayakumar, R. An Introductory Chapter: Secondary Metabolites In: Secondary Metabolites: Sources and Applications, Vijayakumar R.; Suresh S.S. Raja, Ed(s). , 2018; 148, .
[28]
Al-Enazi, N.M. Phytochemical screening and biological activities of some species of Alpinia and Convolvulus plants. Int. J. Pharmacol., 2018, 14(3), 301-309.
[http://dx.doi.org/10.3923/ijp.2018.301.309]
[29]
Awaad, A.S.; El-Meligy, R.M.; Qenawy, S.A.; Atta, A.H.; Soliman, G.A. Anti-inflammatory, antinociceptive and antipyretic effects of some desert plants. J. Saudi Chem. Soc., 2011, 15(4), 367-373.
[http://dx.doi.org/10.1016/j.jscs.2011.02.004]
[30]
Liu, Q.; Meng, X.; Li, Y.; Zhao, C.N.; Tang, G.Y.; Li, H.B. Antibacterial and antifungal activities of spices. Int. J. Mol. Sci., 2017, 18(6), 1283.
[http://dx.doi.org/10.3390/ijms18061283] [PMID: 28621716]
[31]
Tushar, B.S.; Basak, S.; Sarma, G.C.; Rangan, L. Ethnomedical uses of Zingiberaceous plants of Northeast India. J. Ethnopharmacol., 2010, 132(1), 286-296.
[http://dx.doi.org/10.1016/j.jep.2010.08.032] [PMID: 20727402]
[32]
Weerakkody, N.S.; Caffin, N.; Lambert, L.K.; Turner, M.S.; Dykes, G.A. Synergistic antimicrobial activity of galangal (Alpinia galanga), rosemary (Rosmarinus officinalis) and lemon iron bark (Eucalyptus staigerana) extracts. J. Sci. Food Agric., 2011, 91(3), 461-468.
[http://dx.doi.org/10.1002/jsfa.4206] [PMID: 21218479]
[33]
Kaushik, D.; Yadav, J.; Kaushik, P.; Sacher, D.; Rani, R. Current pharmacological and phytochemical studies of the plant Alpinia galanga. J. Chin. Integr. Med., 2011, 9(10), 1061-1065.
[http://dx.doi.org/10.3736/jcim20111004] [PMID: 22015185]
[34]
Pugialli, H.R.L.; Kaplan, M.A.C.; Gottilieb, O.R. Chemotaxonomy of superorder Zingiberiflorae (sensu Dahlgren) I. Flavonoids. Acta Bot. Bras., 1993, 7, 135-148.
[http://dx.doi.org/10.1590/S0102-33061993000200009]
[35]
Williams, R.J.; Spencer, J.P.; Rice-Evans, C. Flavonoids: Antioxidants or signalling molecules? Free Radic. Biol. Med., 2004, 36(7), 838-849.
[http://dx.doi.org/10.1016/j.freeradbiomed.2004.01.001] [PMID: 15019969]
[36]
Bendjeddou, D.; Lalaoui, K.; Satta, D. Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis. J. Ethnopharmacol., 2003, 88(2-3), 155-160.
[http://dx.doi.org/10.1016/S0378-8741(03)00226-5] [PMID: 12963136]
[37]
Ibrahim, H.; Aziz, A.N.; Syamsir, D.R.; Ali, N.A.M.; Mohtar, M.; Ali, R.M.; Awang, K. Essential oils of Alpinia conchigera Griff. and their antimicrobial activities. Food Chem., 2009, 113(2), 575-577.
[http://dx.doi.org/10.1016/j.foodchem.2008.08.033]
[38]
Lee, J.; Kim, K.A.; Jeong, S.; Lee, S.; Park, H.J.; Kim, N.J.; Lim, S. Anti-inflammatory, anti-nociceptive, and anti-psychiatric effects by the rhizomes of Alpinia officinarum on complete Freund’s adjuvant-induced arthritis in rats. J. Ethnopharmacol., 2009, 126(2), 258-264.
[http://dx.doi.org/10.1016/j.jep.2009.08.033] [PMID: 19715749]
[39]
Victório, C.P.; Kuster, R.M.; Moura, R.S.D.; Lage, C.L.S. Vasodilator activity of extracts of field Alpinia purpurata (Vieill) K: Schum and A. zerumbet (Pers.) Burtt et Smith cultured in vitro. Braz. J. Pharm. Sci., 2009, 45(3), 507-514.
[http://dx.doi.org/10.1590/S1984-82502009000300017]
[40]
Da Costa, L.A.M.A.; Morais, S.M.; Dantas, M.C.B.R.; Lobo, R.A.C.M.; Fonteles, M.C. Flavonóides com atividade hipotensora de Alpinia zerumbet (Pers.) Burt et Smith (colônia). Rev. Bras. Farmacogn., 1998, 79, 96-98.
[41]
Jirovetz, L.; Buchbauer, G.; Shafi, M.P.; Leela, N.K. Analysis of the essential oils of the leaves, stems, rhizomes and roots of the medicinal plant Alpinia galanga from southern India. Acta Pharm., 2003, 53(2), 73-81.
[PMID: 14764241]
[42]
Joseph, R.; Joseph, T.; Joseph, J. Volatile essential oil constituents of Alpinia smithiae (Zingiberaceae). Rev. Biol. Trop., 2001, 49(2), 509-512.
[PMID: 11935900]
[43]
Abu Ahmed, A.M.; Sharmen, F.; Mannan, A.; Rahman, M.A. Phytochemical, analgesic, antibacterial, and cytotoxic effects of Alpinia nigra (Gaertn.) Burtt leaf extract. J. Tradit. Complement. Med., 2015, 5(4), 248-252.
[http://dx.doi.org/10.1016/j.jtcme.2014.11.012] [PMID: 26587396]
[44]
Oonmetta-aree, J.; Suzuki, T.; Gasaluck, P.; Eumkeb, G. Antimicrobial properties and action of galangal (Alpinia galanga Linn.) on Staphylococcus aureus. Lebensm. Wiss. Technol., 2006, 39(10), 1214-1220.
[http://dx.doi.org/10.1016/j.lwt.2005.06.015]
[45]
Janssen, A.M.; Scheffer, J.J.C. Acetoxychavicol acetate, an antifungal component of Alpinia galanga. Planta Med., 1985, 51(6), 507-511.
[http://dx.doi.org/10.1055/s-2007-969577] [PMID: 3841613]
[46]
Baradwaj, R.G.; Rao, M.V.; Senthil Kumar, T. Novel purification of 1‘S-1’-Acetoxychavicol acetate from Alpinia galanga and its cytotoxic plus antiproliferative activity in colorectal adenocarcinoma cell line SW480. Biomed. Pharmacother., 2017, 91, 485-493.
[http://dx.doi.org/10.1016/j.biopha.2017.04.114] [PMID: 28477464]
[47]
Ye, Y.; Li, B. 1‘S-1’-acetoxychavicol acetate isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking Rev transport. J. Gen. Virol., 2006, 87(Pt 7), 2047-2053.
[http://dx.doi.org/10.1099/vir.0.81685-0] [PMID: 16760408]
[48]
Sawamura, R.; Sun, Y.; Yasukawa, K.; Shimizu, T.; Watanabe, W.; Kurokawa, M. Antiviral activities of diarylheptanoids against influenza virus in vitro. J. Nat. Med., 2010, 64(1), 117-120.
[http://dx.doi.org/10.1007/s11418-009-0372-2] [PMID: 20091245]
[49]
Heo, M.Y.; Sohn, S.J.; Au, W.W. Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate. Mutat. Res., 2001, 488(2), 135-150.
[http://dx.doi.org/10.1016/S1383-5742(01)00054-0] [PMID: 11344041]
[50]
de Araújo, F.Y.R.; de Oliveira, G.V.; Gomes, P.X.L.; Soares, M.A.; Silva, M.I.G.; Carvalho, A.F.; de Moraes, M.O.; de Moraes, M.E.A.; Vasconcelos, S.M.M.; Viana, G.S.B.; de Sousa, F.C.F.; Macêdo, D.S. Inhibition of ketamine-induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: Possible involvement of an antioxidant effect. J. Pharm. Pharmacol., 2011, 63(8), 1103-1110.
[http://dx.doi.org/10.1111/j.2042-7158.2011.01312.x] [PMID: 21718294]
[51]
Matsuda, H.; Morikawa, T.; Managi, H.; Yoshikawa, M. Antiallergic principles from Alpinia galanga: Structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-α and IL-4 in RBL-2H3 cells. Bioorg. Med. Chem. Lett., 2003, 13(19), 3197-3202.
[52]
Kakegawa, T.; Takase, S.; Masubuchi, E.; Yasukawa, K. Diarylheptanoids from Alpinia officinarum cause distinct but overlapping effects on the translatome of B lymphoblastoid cells. Evid. Based Complement. Alternat. Med., 2014, 2014204797
[http://dx.doi.org/10.1155/2014/204797] [PMID: 25254051]
[53]
Gewali, M.B.; Tezuka, Y.; Banskota, A.H.; Ali, M.S.; Saiki, I.; Dong, H.; Kadota, S.; Epicalyxin, F.; Calyxin, I. Two Novel Antiproliferative Diarylheptanoids from the Seeds of Alpinia blepharocalyx. Org. Lett., 1999, 1(11), 1733-1736.
[http://dx.doi.org/10.1021/ol990260p] [PMID: 10836033]
[54]
Malek, S.N.A.; Phang, C.W.; Ibrahim, H.; Norhanom, A.W.; Sim, K.S. Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes. Molecules, 2011, 16(1), 583-589.
[http://dx.doi.org/10.3390/molecules16010583] [PMID: 21240148]
[55]
Satish, R.; Dhananjayan, R. Evaluation of anti-inflammatory potential of rhizome of Alpinia galanga Linn. Biomedicine-Trivandrum Then Taramani, 2003, 23(1/2), 91-96.
[56]
Lin, C.T.; Senthil Kumar, K.J.; Tseng, Y.H.; Wang, Z.J.; Pan, M.Y.; Xiao, J.H.; Chien, S.C.; Wang, S.Y. Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. J. Agric. Food Chem., 2009, 57(14), 6060-6065.
[http://dx.doi.org/10.1021/jf900517d] [PMID: 19537711]
[57]
Lee, M.Y.; Seo, C.S.; Lee, J.A.; Shin, I.S.; Kim, S.J.; Ha, H.; Shin, H.K. Alpinia katsumadai H(AYATA) seed extract inhibit LPS-induced inflammation by induction of heme oxygenase-1 in RAW264.7 cells. Inflammation, 2012, 35(2), 746-757.
[http://dx.doi.org/10.1007/s10753-011-9370-0] [PMID: 21830094]
[58]
An, L.J.; Guan, S.; Shi, G.F.; Bao, Y.M.; Duan, Y.L.; Jiang, B. Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells. Food Chem. Toxicol., 2006, 44(3), 436-443.
[http://dx.doi.org/10.1016/j.fct.2005.08.017] [PMID: 16223555]
[59]
Shi, G.F.; An, L.J.; Jiang, B.; Guan, S.; Bao, Y.M. Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neurosci. Lett., 2006, 403(3), 206-210.
[http://dx.doi.org/10.1016/j.neulet.2006.02.057] [PMID: 16806694]
(59a) Akhtar, M.S; Khan, M.A.; Malik, M.T. Hypoglycaemic activity of Alpinia galanga rhizome and its extracts in rabbits. Fitoterapia,, 2002, 73(7-8), 623-628.
[http://dx.doi.org/10.1016/S0367-326X(02)00235-6] [PMID: 12490221]
[60]
Verma, R.K.; Mishra, G.; Singh, P.; Jha, K.K.; Khosa, R.L. Anti-diabetic activity of methanolic extract of Alpinia galanga Linn. aerial parts in streptozotocin induced diabetic rats. Ayu, 2015, 36(1), 91-95.
[http://dx.doi.org/10.4103/0974-8520.169006] [PMID: 26730146]
[61]
Miyazawa, M.; Nakamura, Y.; Ishikawa, Y. Insecticidal sesquiterpene from Alpinia oxyphylla against Drosophila melanogaster. J. Agric. Food Chem., 2000, 48(8), 3639-3641.
[http://dx.doi.org/10.1021/jf000325z] [PMID: 10956162]
[62]
Sukhirun, N.; Pluempanupat, W.; Bullangpoti, V. Impact of Alpinia galanga rhizome extract on Bactrocera dorsalis population. Commun. Agric. Appl. Biol. Sci., 2010, 75(3), 399-403.
[PMID: 21539259]
[63]
Kaur, A.; Singh, R.; Dey, C.S.; Sharma, S.S.; Bhutani, K.K.; Singh, I.P. Antileishmanial phenylpropanoids from Alpinia galanga (Linn.). Willd. Indian J. Exp. Biol., 2010, 48(3), 314-317.
[PMID: 21046987]
[64]
Lahlou, S.; Interaminense, L.F.L.; Leal-Cardoso, J.H.; Duarte, G.P. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Fundam. Clin. Pharmacol., 2003, 17(3), 323-330.
[http://dx.doi.org/10.1046/j.1472-8206.2003.00150.x] [PMID: 12803571]
[65]
Jantan, I.; Raweh, S.M.; Sirat, H.M.; Jamil, S.; Mohd Yasin, Y.H.; Jalil, J.; Jamal, J.A. Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. Phytomedicine, 2008, 15(4), 306-309.
[http://dx.doi.org/10.1016/j.phymed.2007.08.002] [PMID: 17913483]
[66]
Rao, K.; Ch, B.; Narasu, L.M.; Giri, A. Antibacterial activity of Alpinia galanga (L) Willd crude extracts. Appl. Biochem. Biotechnol., 2010, 162(3), 871-884.
[http://dx.doi.org/10.1007/s12010-009-8900-9] [PMID: 20387130]
[67]
Sivasothy, Y.; Zachariah, C.C.K.; Leong, K.H.; John, S.K.S.; Ibrahim, H.; Awang, K. A novel heptacyclic diterpene from Alpinia pahangensis Ridley, a wild ginger endemic to Malaysia. Tetrahedron Lett., 2014, 55(45), 6163-6166.
[http://dx.doi.org/10.1016/j.tetlet.2014.08.115]
[68]
Hemabarathy, B.; Budin, S.B.; Feizal, V. Paracetamol hepatotoxicity in rats treated with crude extract of Alpinia galanga. J. Biol. Sci., 2009, 9(1), 57-62.
[http://dx.doi.org/10.3923/jbs.2009.57.62]
[69]
Khattak, S. Saeed-ur-Rehman.; Ullah Shah, H.; Ahmad, W.; Ahmad, M. Biological effects of indigenous medicinal plants Curcuma longa and Alpinia galanga. Fitoterapia, 2005, 76(2), 254-257.
[http://dx.doi.org/10.1016/j.fitote.2004.12.012] [PMID: 15810156]
[70]
Niyomkam, P.; Kaewbumrung, S.; Kaewnpparat, S.; Panichayupakaranant, P. Antibacterial activity of Thai herbal extracts on acne involved microorganism. Pharm. Biol., 2010, 48(4), 375-380.
[http://dx.doi.org/10.3109/13880200903150443] [PMID: 20645714]
(70a) Oliveira, A.C.D.; Valentim, I.B.; Goulart, M.O.F. Natural plant sources of antioxidants. Quim. New, 2009, 32(3)
[71]
Itokawa, H.; Morita, H.; Sumitomo, T.; Totsuka, N.; Takeya, K. Antitumour principles from Alpinia galanga. Planta Med., 1987, 53(1), 32-33.
[http://dx.doi.org/10.1055/s-2006-962611] [PMID: 3575509]
[72]
Lu, Y.H. Lin-Tao.; Wang, Z.T.; Wei, D.Z.; Xiang, H.B. Mechanism and inhibitory effect of galangin and its flavonoid mixture from Alpinia officinarum on mushroom tyrosinase and B16 murine melanoma cells. J. Enzyme Inhib. Med. Chem., 2007, 22(4), 433-438.
[http://dx.doi.org/10.1080/14756360601141562] [PMID: 17847709]
[73]
Fan, G.J.; Kang, Y.H.; Han, Y.N.; Han, B.H. Platelet-Activating Factor (PAF) receptor binding antagonists from Alpinia officinarum. Bioorg. Med. Chem. Lett., 2007, 17(24), 6720-6722.
[http://dx.doi.org/10.1016/j.bmcl.2007.10.054] [PMID: 17964782]
[74]
Grienke, U.; Schmidtke, M.; Kirchmair, J.; Pfarr, K.; Wutzler, P.; Dürrwald, R.; Wolber, G.; Liedl, K.R.; Stuppner, H.; Rollinger, J.M. Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J. Med. Chem., 2009, 53(2), 778-786.
[75]
Nam, J.W.; Kim, S.J.; Han, A.R.; Lee, S.K.; Seo, E.K. Cytotoxic phenylpropanoids from the rhizomes of Alpinia galanga. Biomolec. Therapeut., 2005, 13(4), 263-266.
[76]
An, N.; Zou, Z.M.; Tian, Z.; Luo, X.Z.; Yang, S.L.; Xu, L.Z. Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity. Fitoterapia, 2008, 79(1), 27-31.
[http://dx.doi.org/10.1016/j.fitote.2007.07.001] [PMID: 17916414]
[77]
Ali, M.S.; Banskota, A.H.; Tezuka, Y.; Saiki, I.; Kadota, S. Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyx. Biol. Pharm. Bull., 2001, 24(5), 525-528.
[http://dx.doi.org/10.1248/bpb.24.525] [PMID: 11379774]
[78]
Yasuhara, T.; Manse, Y.; Morimoto, T.; Qilong, W.; Matsuda, H.; Yoshikawa, M.; Muraoka, O. Acetoxybenzhydrols as highly active and stable analogues of 1‘S-1’-acetoxychavicol, a potent antiallergic principal from Alpinia galanga. Bioorg. Med. Chem. Lett., 2009, 19(11), 2944-2946.
[http://dx.doi.org/10.1016/j.bmcl.2009.04.065] [PMID: 19414259]
[79]
Elzaawely, A.A.; Xuan, T.D.; Tawata, S. Essential oils, kava pyrones and phenolic compounds from leaves and rhizomes of Alpinia zerumbet (Pers.) BL Burtt. & RM Sm. and their antioxidant activity. Food Chem., 2007, 103(2), 486-494.
[http://dx.doi.org/10.1016/j.foodchem.2006.08.025]
[80]
Zhang, W.J.; Luo, J.G.; Kong, L.Y. The genus Alpinia: A review of its phytochemistry and pharmacology. World J. Tradit. Chin. Med., 2016, 2, 26-41.
[http://dx.doi.org/10.15806/j.issn.2311-8571.2015.0026]
[81]
Gong, J.; Zhang, Z.; Zhang, X.; Chen, F.; Tan, Y.; Li, H.; Jiang, J.; Zhang, J. Effects and possible mechanisms of Alpinia officinarum ethanol extract on indomethacin-induced gastric injury in rats. Pharm. Biol., 2018, 56(1), 294-301.
[http://dx.doi.org/10.1080/13880209.2018.1450426] [PMID: 29781354]
[82]
Ma, X.N.; Xie, C.L.; Miao, Z.; Yang, Q.; Yang, X.W. An overview of chemical constituents from Alpinia species in the last six decades. RSC Advances, 2017, 7(23), 14114-14144.
[http://dx.doi.org/10.1039/C6RA27830B]
[83]
Awang, K.; Azmi, M.N.; Aun, L.I.; Aziz, A.N.; Ibrahim, H.; Nagoor, N.H.; Ibrahim, H. The apoptotic effect of 1‘s-1’-acetoxychavicol acetate from Alpinia conchigera on human cancer cells. Molecules, 2010, 15(11), 8048-8059.
[http://dx.doi.org/10.3390/molecules15118048] [PMID: 21063268]
[84]
Basri, A.M.; Taha, H.; Ahmad, N. A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation. Pharmacogn. Rev., 2017, 11(21), 23.
[85]
Al-Adhroey, A.H.; Nor, Z.M.; Al-Mekhlafi, H.M.; Mahmud, R. Median lethal dose, antimalarial activity, phytochemical screening and radical scavenging of methanolic Languas galanga rhizome extract. Molecules, 2010, 15(11), 8366-8376.
[http://dx.doi.org/10.3390/molecules15118366] [PMID: 21081857]

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