Abstract
An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.
Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.
Letters in Organic Chemistry
Title:Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones
Volume: 10 Issue: 7
Author(s): Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berree, Bertrand Carboni and Abdelmadjid Debache
Affiliation:
Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.
Abstract: An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.
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Sehout Imene, Boulcina Raouf, Boumoud Boudjemaa, Berree Fabienne, Carboni Bertrand and Debache Abdelmadjid, Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones, Letters in Organic Chemistry 2013; 10 (7) . https://dx.doi.org/10.2174/15701786113109990014
DOI https://dx.doi.org/10.2174/15701786113109990014 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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