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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review

Author(s): Giuseppe Cammarata, Giovanni Duro*, Tiziana Di Chiara, Alessia Lo Curto, Simona Taverna and Giuseppina Candore

Volume 25, Issue 39, 2019

Page: [4150 - 4153] Pages: 4

DOI: 10.2174/1381612825666191119091644

Price: $65

Abstract

Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular levels. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflammaging, is a common biological factor responsible for the decline and beginning of the disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of aging phenotype. Moreover, lifestyle can influence the physiological status of multiple organs, via epigenetic mechanisms. Recently, microRNAs are considered potential sensors of aging.

Keywords: Circulating miRNAs, aging, exosome, inflammation mediators, age-related diseases, miR-21-5p, miR-126.

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