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Review Article

Leptin and Its Derivatives: A Potential Target for Autoimmune Diseases

Author(s): Han Han and Weiqiang Zhou*

Volume 20, Issue 15, 2019

Page: [1563 - 1571] Pages: 9

DOI: 10.2174/1389450120666190729120557

Price: $65

Abstract

Leptin is an adipocyte-derived hormone product of the obese (ob) gene. Leptin plays an important regulatory role as an immunomodulatory factor in the maintenance and homeostasis of immune functions. Indeed, the role of leptin as an immunomodulator in inflammatory and immune responses has attracted increasing attention in recent years. Leptin mostly affects responses through the immunomodulation of monocytes, dendritic cells, neutrophils, NK cells, and dendritic cells in addition to modulating T and B cell development and functions. Leptin is also an important inflammatory regulator, wherein higher expression influences the secretion rates of IL-6, C-reactive proteins, and TNF-α. Moreover, leptin is highly involved in processes related to human metabolism, inflammatory reactions, cellular development, and diseases, including hematopoiesis. Owing to its diverse immunerelated functions, leptin has been explored as a potential target for therapeutic development in the treatment of autoimmune diseases.

Keywords: leptin, immune response, autoimmune diseases, adipocyte-derived, obese (ob) gene, dendritic cells.

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