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Review Article

瘦素及其衍生物：自身免疫性疾病的潜在目标

卷 20, 期 15, 2019

页: [1563 - 1571] 页: 9

弟呕挨: 10.2174/1389450120666190729120557

价格: $65

摘要

瘦素是肥胖（ob）基因的脂肪细胞源性激素产物。瘦蛋白在免疫功能的维持和体内平衡中作为免疫调节因子起着重要的调节作用。实际上，近年来，瘦素作为免疫调节剂在炎症和免疫应答中的作用已引起越来越多的关注。瘦素主要通过调节单核细胞，树突状细胞，嗜中性粒细胞，NK细胞和树突状细胞的免疫调节来影响应答，此外还调节T和B细胞的发育和功能。瘦素也是重要的炎症调节剂，其中高表达影响IL-6，C反应蛋白和TNF-α的分泌率。此外，瘦素高度参与与人类代谢，炎性反应，细胞发育和疾病（包括造血）有关的过程。由于其多样化的免疫相关功能，瘦素已被开发为治疗自身免疫性疾病的潜在治疗靶标。

关键词: 瘦素，免疫应答，自身免疫性疾病，脂肪细胞来源的，肥胖（ob）基因，树突状细胞。

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