Abstract
Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.
Keywords: Nitric oxide, cGMP, nitric oxide synthase, guanylyl cyclase, phosphodiesterase, traditional Chinese medicine, drug development, numerous efforts, drug and formulation discovery, promising approaches
Current Medicinal Chemistry
Title: Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development
Volume: 18 Issue: 22
Author(s): A.Y. Kots, K. Bian and F. Murad
Affiliation:
Keywords: Nitric oxide, cGMP, nitric oxide synthase, guanylyl cyclase, phosphodiesterase, traditional Chinese medicine, drug development, numerous efforts, drug and formulation discovery, promising approaches
Abstract: Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.
Export Options
About this article
Cite this article as:
Kots A.Y., Bian K. and Murad F., Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development, Current Medicinal Chemistry 2011; 18 (22) . https://dx.doi.org/10.2174/092986711796504646
DOI https://dx.doi.org/10.2174/092986711796504646 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Silent Cerebral Damage in Hypertension
Current Hypertension Reviews The Hemodynamics of Septic Shock: A Historical Perspective
Current Vascular Pharmacology Urocortins: Putative Role in Cardiovascular Disease
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Diabetes and Its Complications: Therapies Available, Anticipated and Aspired
Current Diabetes Reviews The Detection of Adverse Events in Randomized Clinical Trials: Can we Really Say New Medicines are Safe?
Current Drug Safety Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion
Cardiovascular & Hematological Disorders-Drug Targets Emerging Therapy for Diabetic Neuropathy: Cell Therapy Targeting Vessels and Nerves
Endocrine, Metabolic & Immune Disorders - Drug Targets Chemical Constituents and Biological Significance of the Genus Ilex (Aquifoliaceae)
The Natural Products Journal Pharmacological Interventions on Asymmetric Dimethylarginine, a Clinical Marker of Vascular Disease
Current Medicinal Chemistry Non-Clinical Screening of Cyto-Genotoxicologic Status of Praziquantel Nanoemulsion
Current Bioactive Compounds Quinazolin-4-One: A Varsatile Molecule
Current Bioactive Compounds Cognitive Impairment in the Septic Brain
Current Neurovascular Research Reversible Michael Additions: Covalent Inhibitors and Prodrugs
Mini-Reviews in Medicinal Chemistry Goal Directed Fluid Therapy
Current Pharmaceutical Design The Role of Transcription Factors in the Formation of an Arrhythmogenic Substrate in Congestive Human Heart Failure
Current Medicinal Chemistry Protease-Activated Receptors (PARs) are Partly Pro-Inflammatory and Partly Anti-Inflammatory: Will PAR Agonists or Antagonists Participate in Future Drug Therapies?
Current Drug Targets New Developments in Antimicrobial Use in Sepsis
Current Pharmaceutical Design Functional Roles of Benzothiazole Motif in Antiepileptic Drug Research
Mini-Reviews in Medicinal Chemistry An Insight into the Therapeutic Potential of Major Coffee Components
Current Drug Metabolism Novel Immunotherapies for Hematological Malignancies
Current Molecular Pharmacology