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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Research Article

Effect of Levetiracetam on Cognitive Function and Clonic Seizure Frequency in Children with Epilepsy

Author(s): Shihao Zhou, Qiong Zhan and Xiaomei Wu*

Volume 19, Issue 9, 2019

Page: [699 - 703] Pages: 5

DOI: 10.2174/1566524019666190729113321

Price: $65

Abstract

Objective: This study aimed to explore the clinical effect of levetiracetam in the treatment of children with epilepsy.

Methods: 136 children with epilepsy were selected from January 2017 to December 2017. According to the random number table method, they were divided into the experimental group and the conventional group, with 68 cases in each group. The conventional group was treated with valproate, while the experimental group was treated with levetiracetam. The effective rate, the cognitive function and the frequency of clonic seizures in the two groups were compared.

Results: There was no significant difference in the total effective rate between the two groups (P>0.05). There was no significant difference in attention, executive ability, abstract and orientation scores between the two groups before treatment (P>0.05). After treatment, the focus of attention (106.54±6.56), executive ability (105.76±6.77), abstract and directional score (106.65±6.57) were significantly higher than that of the conventional group. The difference in the two groups was statistically significant (P<0.05). After 3 months of treatment, the frequency of myoclonic seizures (9.22±0.95) and the frequency of tonic-clonic seizures (11.68±1.36) were found to be significantly lower than those of the conventional group, and the difference between the two groups was statistically significant (P<0.05).

Conclusion: Levetiracetam is effective in the treatment of children with epilepsy. It can effectively improve the cognitive function of the patients, reduce the frequency of myoclonic seizures and tonic-clonic seizures, and has a high promotion value.

Keywords: Epilepsy, levetiracetam, cognitive function, clonic seizure, myoclonic seizures.

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[1]
Parazzini F, Cintio E D, Chatenoud L, et al. Estroprogestin vs. gonadotrophin agonists plus estroprogestin in the treatment of endometriosis-related pelvic pain: a randomized trial. Eur J Obstet Gynecol Reprod Biol 2000; 88: 0-14.
[2]
Dmowski WP, Pry M, Ding J, Rana N. Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer. Fertil Steril 2002; 78: 750-6.
[3]
Camran R. Siegler,Nezhat,et alOperative gynecologic laparoscopy:principles and techniques. 2nd ed. New York: Mc Graw-Hill Publishing House 1996.
[4]
Yang Y, Zhang X, Zhou C, Huang X, Lin J, Xu H. Elevated immunoreactivity of RANTES and CCR1 correlate with the severity of stages and dysmenorrhea in women with deep infiltrating endometriosis. Acta Histochem 2013; 115: 434-9.
[5]
Govatati S, Kodati VL, Deenadayal M, Chakravarty B, Shivaji S, Bhanoori M. Mutations in the PTEN tumor gene and risk of endometriosis: A case-control study. Hum Reprod 2014; 29: 324-6.
[6]
Lu H, Yang X, Zhang Y, Lu R, Wang X. Epigenetic Disorder May Cause Downregulation of HOXA10 in the Eutopic Endometrium of Fertile Women With Endometriosis. Reprod Sci 2013; 20: 78-84.
[7]
Mormile R, Vittori G. Is endometriosis ultimately the end result of the interplay between interferon-γ (IFN-γ) and the HOXA10 gene network? J Pediatr Endocrinol Metab 2013; 26: 607-8.
[8]
Fambrini M, Sorbi F, Bussani C, Cioni R, Sisti G, Andersson KL. Hypermethylation of HOXA10 gene in mid-luteal endometrium from women with ovarian endometriomas. Acta Obstet Gynecol Scand 2013; 92: 1331-4.
[9]
Zanatta A, André M. Rocha, Carvalho F M, et al. The role of the Hoxa10/HOXA10, gene in the etiology of endometriosis and its related infertility: a review. J Assist Reprod Genet 2010; 27: 701-10.
[10]
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction 2012; 143: 531-8.
[11]
Szczepańska Malgorzata , Wirstlein P, Luczak M, Jagodziński PP, Skrzypczak J. Reduced expression of HOXA10 in the midluteal endometrium from infertile women with minimal endometriosis. Biomed Pharmacother 2010; 64: 697-705.
[12]
Zanatta A, Pereira RM, Rocha AM, et al. The relationship among HOXA10, estrogen receptor? progesterone receptor, and progesterone receptor B proteins in rectosigmoid endometriosis: A tissue microarray study. Reprod Sci 2015; 22: 31-7.
[13]
Zhu LH, Sun LH, Hu YL, et al. PCAF impairs endometrial receptivity and embryo implantation by down-regulating β3-integrin expression via HOXA10 acetylation. J Clin Endocrinol Metab 2013; 98: 4417-28.
[14]
Zanatta A, Rocha AM, Carvalho FM, et al. The role of the Hoxa10/HOXA10, gene in the etiology of endometriosis and its related infertility: a review. J Assist Reprod Genet 2010; 27: 701-10.
[15]
Lee B, Du H, Taylor HS. Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod 2009; 80: 79-85.
[16]
Fassbender A, Verbeeck N, Börnigen D, et al. Combined mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis. Hum Reprod 2012; 27: 2020-9.
[17]
Hu WP, Tay SK, Zhao Y. Endometriosis-specific genes identified by real-time reverse transcription-polymerase chain reaction expression profiling of endometriosis\r, versus\r, autologous uterine endometrium. J Clin Endocrinol Metab 2006; 91: 228-38.
[18]
Hur SE, Lee JY, Moon HS, Chung HW. Angiopoietin-1, angiopoietin-2 and Tie-2 expression in eutopic endometrium in advanced endometriosis. Mol Hum Reprod 2006; 12: 421-6.
[19]
Matsuzaki S, Darcha C. Adenosine triphosphate-binding cassette transporter G2 expression in?endometriosis and in endometrium from patients with and without endometriosis. Fertil Steril 2012; 98: 1512-1520.e3.
[20]
Brosens I, Brosens JJ, Benagiano G. The eutopic endometrium in endometriosis: are the changes of clinical significance? Reprod Biomed Online 2012; 24: 496-502.

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