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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Strategies to Control Human Lymphatic Filarial Infection: Tweaking Host’s Immune System

Author(s): Puvvada Kalpana Murthy*

Volume 19, Issue 14, 2019

Page: [1226 - 1240] Pages: 15

DOI: 10.2174/1568026619666190618110613

Price: $65

Abstract

Human lymphatic filariasis (LF), a parasitic infection caused by the nematodes Wuchereria bancrofti, Brugia malayi and B. timori, and transmitted by mosquito, results in a debilitating disease commonly identified as ‘elephantiasis’. LF affects millions of people in India and several other tropical and sub-tropical countries imposing a huge economic burden on governments due to disability associated loss of man-hours and for disease management. Efforts to control the infection by WHO’s mass drug administration (MDA) strategy using three antifilarials diethylcarbamazine, albendazole and ivermectin are only partly successful and therefore, there is an immediate need for alternative strategies. Some of the alternative strategies being explored in laboratories are: enhancing the immune competence of host by immunomodulation, combining immunomodulation with antifilarials, identifying immunoprophylactic parasite molecules (vaccine candidates) and identifying parasite molecules that can be potential drug targets. This review focuses on the advances made in this direction.

Keywords: Lymphatic filariasis, Antifilarials, Host's immune responses, Immunomodulation, Infection control, Parasite molecules.

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