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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Pharmaceutical Mixtures: Still A Concern for Human and Environmental Health

Author(s): Georgeta M. Simu, Jeanne Atchana , Codruta M. Soica, Dorina E. Coricovac, Sebastian C. Simu and Cristina A. Dehelean*

Volume 27, Issue 1, 2020

Page: [121 - 153] Pages: 33

DOI: 10.2174/0929867325666181108094222

Price: $65

Abstract

In the present work, recent data on the sources, occurrence and fate of human-use pharmaceutical active compounds (PhACs) in the aquatic environment have been reviewed. Since PhACs and their metabolites are usually present as mixtures in the environment at very low concentrations, a particular emphasis was placed onto the PhACs mixtures, as well as on their short-term and long-term effects against human and environmental health. Moreover, a general overview of the main conventional as well as of the latest trends in wastewaters decontaminant technologies was outlined. Advantages and disadvantages of current processes were also pointed out. It appears that numerous gaps still exist in the current knowledge related to this field of interest, and further studies should be conducted at the global level in order to ensure a more efficient monitorisation of the presence of PhACs and their metabolites into the aquatic environment and to develop new mitigation measures.

Keywords: Pharmaceuticals, ecotoxicological effects, pharmaceutical mixtures, decontaminant technologies, advanced oxidation processes, nanomaterials.

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