Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates

Title:Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates

Volume: 22 Issue: 21

Author(s): Antonella Leggio*, Emilia Lucia Belsito, Alessandra Comandè, Valentina Papaianni and Angelo Liguori*

Affiliation:

• Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS),Italy

• Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS),Italy

Keywords: Benzyl alcohol, diarylmethanes, friedel crafts reactions, substituted benzyl alcohols, titanium tetrachloride, aromatic substrates.

Abstract: Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.

Cite this article as:

Leggio Antonella*, Belsito Lucia Emilia, Comandè Alessandra, Papaianni Valentina and Liguori Angelo*, Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates, Current Organic Chemistry 2018; 22 (21) . https://dx.doi.org/10.2174/1385272822666181010125902