Abstract
Rapid developments in protein engineering, immunology and pharmaceutical research have led to immense demands for synthetic polypeptides. Several polypeptides synthesizing strategies are now available, among which solid-phase synthesis and solution- phase synthesis are especially relevant. This review pretended to compare these two synthesizing strategies with no bias, appreciate their advantages, drawbacks and limitations, and forecast their developmental trends. It also introduced several other special synthetic strategies, and their applications were presented in detail.
Keywords: Peptide, oligopeptide, synthetic peptide, solid phase synthesis, solution phase synthesis, microwave-assisted.
Graphical Abstract
Current Organic Chemistry
Title:Current Status and Future Developments in Synthetic Peptides
Volume: 22 Issue: 20
Author(s): Bing Yu, Ankang Zhang, Min Zhang, Wenli Wang, Wenlong Li, Youqing Shen and Hailin Cong*
Affiliation:
- Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071,China
Keywords: Peptide, oligopeptide, synthetic peptide, solid phase synthesis, solution phase synthesis, microwave-assisted.
Abstract: Rapid developments in protein engineering, immunology and pharmaceutical research have led to immense demands for synthetic polypeptides. Several polypeptides synthesizing strategies are now available, among which solid-phase synthesis and solution- phase synthesis are especially relevant. This review pretended to compare these two synthesizing strategies with no bias, appreciate their advantages, drawbacks and limitations, and forecast their developmental trends. It also introduced several other special synthetic strategies, and their applications were presented in detail.
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Cite this article as:
Yu Bing , Zhang Ankang , Zhang Min , Wang Wenli , Li Wenlong , Shen Youqing and Cong Hailin *, Current Status and Future Developments in Synthetic Peptides, Current Organic Chemistry 2018; 22 (20) . https://dx.doi.org/10.2174/1385272822666181009151945
DOI https://dx.doi.org/10.2174/1385272822666181009151945 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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