Abstract
A number of papers reporting antimicrobial properties of extracts, essential oils, resins and various classes of compounds isolated from higher plants have been published in recent years; however, a comprehensive analysis of plant-derived antimicrobial agents currently applied in practice for the improvement of human health is still lacking. This review summarizes data on clinical efficacy, antimicrobial effects and the chemistry of commercially available antibacterial and antifungal agents of plant origin currently used in the prevention and treatment of gastrointestinal, oral, respiratory, skin, and urinary infections. As a result of an analysis of the literature, more than 40 plant-derived over-the-counter pharmaceuticals, dietary supplements, cosmetics, herbal medicines, and functional foods containing complex mixtures (e.g. Glycyrrhiza glabra extract, Melaleuca alternifolia essential oil, and Pistacia lentiscus resin), pure compounds (e.g. benzoic acid, berberine, eucalyptol, salicylic acid and thymol) as well as their derivatives and complexes (e.g. bismuth subsalicylate and zinc pyrithione) have been identified. The effectiveness of many of these products is illustrated by results of clinical trials and supported by data on there in vitro antimicrobial activity. A broad spectrum of various commercial products currently available on the market and their welldocumented clinical efficacy suggests that plants are prospective sources for the identification of new types of antimicrobial agents in future. Innovative approaches and methodologies for effective proof-of-concept research and the development of new types of plant-derived products effective against recently emerging problems related to human microbial diseases (e.g. antimicrobial resistance) are also proposed in this review.
Keywords: Plant, extract, essential oil, compound, antibacterial, antifungal, commercial products.
[http://dx.doi.org/10.1038/nbt1206-1504] [PMID: 17160050]
[http://dx.doi.org/10.1016/j.anbehav.2005.03.005]
[http://dx.doi.org/10.1016/j.mam.2005.07.008] [PMID: 16105678]
[http://dx.doi.org/10.1126/science.1155165] [PMID: 18420924]
[http://dx.doi.org/10.1016/j.jep.2011.04.051] [PMID: 21549817]
[http://dx.doi.org/10.1128/CMR.12.4.564] [PMID: 10515903]
[http://dx.doi.org/10.2174/0929867033457719] [PMID: 12678685]
[http://dx.doi.org/10.2174/0929867043365107] [PMID: 15180577]
[http://dx.doi.org/10.1016/j.ijantimicag.2005.09.002] [PMID: 16323269]
[http://dx.doi.org/10.2174/1381612054367481] [PMID: 16026296]
[http://dx.doi.org/10.1016/j.jep.2005.04.025] [PMID: 15964727]
[http://dx.doi.org/10.1590/S1678-91992010000300006]
[http://dx.doi.org/10.2174/138161211795703807] [PMID: 21470116]
[http://dx.doi.org/10.1039/c2np20035j] [PMID: 22786554]
[http://dx.doi.org/10.1155/2016/3012462] [PMID: 28090211]
[http://dx.doi.org/10.1016/j.micres.2016.12.003] [PMID: 28164790]
[http://dx.doi.org/10.1016/j.jep.2006.04.003] [PMID: 16698208]
[http://dx.doi.org/10.1055/s-2008-1074518] [PMID: 18446673]
[http://dx.doi.org/10.2217/fmb.12.68] [PMID: 22913356]
[http://dx.doi.org/10.1136/gut.2003.022103] [PMID: 14724167]
[http://dx.doi.org/10.1093/jac/dkv155] [PMID: 26078393]
[http://dx.doi.org/10.1136/gutjnl-2012-302084] [PMID: 22491499]
[http://dx.doi.org/10.1007/BF02803833] [PMID: 5518228]
[http://dx.doi.org/10.1007/BF02749333] [PMID: 5355320]
[PMID: 4905644]
[PMID: 5532321]
[PMID: 5131809]
[PMID: 6040104]
[http://dx.doi.org/10.1136/bmj.291.6509.1601] [PMID: 3935203]
[http://dx.doi.org/10.1002/ptr.5475] [PMID: 26400188]
[http://dx.doi.org/10.1093/infdis/155.5.979] [PMID: 3549923]
[http://dx.doi.org/10.1007/s10096-014-2132-9] [PMID: 24820293]
[http://dx.doi.org/10.1128/AAC.32.8.1274] [PMID: 2903716]
[PMID: 7035365]
[http://dx.doi.org/10.1254/fpj.101.3_169] [PMID: 8486321]
[PMID: 1772324]
[http://dx.doi.org/10.1016/j.fitote.2012.05.015] [PMID: 22668974]
[http://dx.doi.org/10.1139/m69-190] [PMID: 4906191]
[http://dx.doi.org/10.1007/BF02818693] [PMID: 12422513]
[http://dx.doi.org/10.4172/2161-069X.1000110]
[http://dx.doi.org/10.1007/BF01649558] [PMID: 1812314]
[http://dx.doi.org/10.1136/bmjopen-2015-010530] [PMID: 26895988]
[http://dx.doi.org/10.4321/S1130-01082009000100005] [PMID: 19335032]
[http://dx.doi.org/10.1016/0031-9422(91)83426-L]
[http://dx.doi.org/10.1080/10408699891274273] [PMID: 9759559]
[http://dx.doi.org/10.1111/j.1472-765X.1993.tb01428.x]
[http://dx.doi.org/10.1016/j.foodchem.2009.05.060]
[http://dx.doi.org/10.1111/j.1744-7348.2002.tb00176.x]
[http://dx.doi.org/10.1093/clinids/12.Supplement_1.S3] [PMID: 2406853]
[http://dx.doi.org/10.1002/ddr.21086]
[http://dx.doi.org/10.1093/infdis/157.5.1008] [PMID: 2896219]
[http://dx.doi.org/10.1016/0002-9343(90)90270-N] [PMID: 2192553]
[PMID: 1984613]
[http://dx.doi.org/10.1056/NEJM199306103282301] [PMID: 8487823]
[http://dx.doi.org/10.1080/080352501750258630] [PMID: 11440090]
[http://dx.doi.org/10.3109/00365529208999958] [PMID: 1502490]
[http://dx.doi.org/10.1007/BF01303177] [PMID: 8359080]
[http://dx.doi.org/10.1080/19490976.2015.1008336] [PMID: 25901890]
[http://dx.doi.org/10.1089/mdr.2013.0086] [PMID: 23844851]
[http://dx.doi.org/10.3390/pathogens3020473] [PMID: 25437810]
[http://dx.doi.org/10.1111/j.1440-1746.2006.04194.x] [PMID: 16911681]
[http://dx.doi.org/10.1111/j.1440-1681.1984.tb00864.x] [PMID: 6395994]
[http://dx.doi.org/10.1007/BF02774571] [PMID: 3732760]
[http://dx.doi.org/10.1016/j.phymed.2009.09.010] [PMID: 19879118]
[http://dx.doi.org/10.1093/jac/dkg366] [PMID: 12888582]
[http://dx.doi.org/10.1097/MEG.0b013e32831c50c9] [PMID: 19212203]
[http://dx.doi.org/10.1056/NEJM199812243392618] [PMID: 9874617]
[http://dx.doi.org/10.1179/joc.2001.13.6.611] [PMID: 11806621]
[http://dx.doi.org/10.1016/S0002-9270(01)02891-X]
[http://dx.doi.org/10.1093/jac/dkg057] [PMID: 12562704]
[http://dx.doi.org/10.1128/AAC.00642-06] [PMID: 17116667]
[http://dx.doi.org/10.1016/S0040-4039(98)00228-7]
[http://dx.doi.org/10.1002/bmc.454] [PMID: 15651084]
[http://dx.doi.org/10.1016/S0021-9673(96)01032-1]
[http://dx.doi.org/10.3181/0811-RM-338] [PMID: 19234052]
[http://dx.doi.org/10.1081/JLC-120027100]
[http://dx.doi.org/10.1080/10412905.1991.9697918]
[http://dx.doi.org/10.1055/s-2006-960856] [PMID: 10630120]
[http://dx.doi.org/10.1021/jf050639s] [PMID: 16190616]
[http://dx.doi.org/10.1007/s13659-014-0033-3] [PMID: 25089241]
[http://dx.doi.org/10.1007/s00726-007-0554-8] [PMID: 17514491]
[http://dx.doi.org/10.1155/2013/263805] [PMID: 23606875]
[http://dx.doi.org/10.1016/j.phymed.2010.08.001] [PMID: 20864324]
[http://dx.doi.org/10.1136/gut.10.4.299] [PMID: 4889526]
[http://dx.doi.org/10.1136/gut.9.1.48] [PMID: 5640926]
[http://dx.doi.org/10.1136/gut.12.6.449] [PMID: 4933135]
[PMID: 772652]
[http://dx.doi.org/10.1136/gut.19.9.779] [PMID: 361512]
[http://dx.doi.org/10.1136/bmj.1.6106.148] [PMID: 339997]
[http://dx.doi.org/10.1136/bmj.2.6095.1123] [PMID: 589019]
[PMID: 373361]
[http://dx.doi.org/10.1136/gut.23.6.545] [PMID: 7042486]
[http://dx.doi.org/10.1016/S0024-3205(02)01864-7] [PMID: 12127165]
[http://dx.doi.org/10.1016/j.jep.2012.11.033] [PMID: 23220194]
[http://dx.doi.org/10.1080/19390211.2016.1223257] [PMID: 27588327]
[http://dx.doi.org/10.1016/j.jep.2009.07.009] [PMID: 19607905]
[PMID: 22257880]
[http://dx.doi.org/10.1136/bmj.306.6879.688] [PMID: 8471920]
[http://dx.doi.org/10.1016/S1286-4579(00)00391-9] [PMID: 10962273]
[http://dx.doi.org/10.1136/bmj.298.6676.779] [PMID: 2496855]
[http://dx.doi.org/10.1128/JCM.43.11.5721-5732.2005] [PMID: 16272510]
[http://dx.doi.org/10.1099/jmm.0.46417-0] [PMID: 16585650]
[PMID: 9826397]
[http://dx.doi.org/10.1128/IAI.68.6.3140-3146.2000] [PMID: 10816455]
[http://dx.doi.org/10.1034/j.1399-302X.1999.140609.x] [PMID: 10895695]
[http://dx.doi.org/10.1136/pmj.78.922.455] [PMID: 12185216]
[http://dx.doi.org/10.1111/j.1600-0757.2008.00253.x] [PMID: 18715356]
[PMID: 14735645]
[http://dx.doi.org/10.1111/j.1600-0757.1997.tb00102.x] [PMID: 9643230]
[http://dx.doi.org/10.1016/j.ijantimicag.2008.07.014] [PMID: 18804350]
[http://dx.doi.org/10.1002/ptr.4606] [PMID: 22318955]
[http://dx.doi.org/10.1002/ptr.4762] [PMID: 22761009]
[http://dx.doi.org/10.1016/S0002-8177(86)24021-0] [PMID: 3517110]
[PMID: 12691269]
[http://dx.doi.org/10.1111/j.1600-051X.2004.00578.x] [PMID: 15367192]
[PMID: 20684443]
[PMID: 22670258]
[http://dx.doi.org/10.1111/j.1601-5037.2012.00556.x] [PMID: 22583681]
[http://dx.doi.org/10.14219/jada.archive.2006.0110] [PMID: 17138709]
[http://dx.doi.org/10.1902/jop.2007.060269] [PMID: 17608576]
[http://dx.doi.org/10.1902/jop.2010.100266] [PMID: 21043801]
[http://dx.doi.org/10.1093/jac/dkp362] [PMID: 19837714]
[http://dx.doi.org/10.1055/s-2005-837790] [PMID: 15729631]
[http://dx.doi.org/10.1515/znc-2010-9-1009] [PMID: 21138060]
[PMID: 18167456]
[http://dx.doi.org/10.1663/0013- 0001(2003)057[0118:IOSMAO]2.0.CO;2]
[http://dx.doi.org/10.1590/S0100-879X2007000300010] [PMID: 17334532]
[http://dx.doi.org/10.1111/j.1399-302X.2005.00216.x] [PMID: 15943766]
[http://dx.doi.org/10.1080/08927014.2012.749398] [PMID: 23216018]
[http://dx.doi.org/10.4014/jmb.1402.02056] [PMID: 24851813]
[http://dx.doi.org/10.3314/jjmm.50.243] [PMID: 19942796]
[http://dx.doi.org/10.3389/fmed.2018.00028] [PMID: 29487851]
[PMID: 2133450]
[http://dx.doi.org/10.1034/j.1600-0528.2002.00061.x] [PMID: 12236827]
[http://dx.doi.org/10.1034/j.1600-0528.2003.00034.x] [PMID: 12752543]
[http://dx.doi.org/10.1159/000065961] [PMID: 12399699]
[http://dx.doi.org/10.1016/S0300-5712(00)00060-9] [PMID: 11525226]
[http://dx.doi.org/10.1159/000262397] [PMID: 9165189]
[http://dx.doi.org/10.1159/000262067] [PMID: 7621493]
[http://dx.doi.org/10.4317/medoral.18261] [PMID: 23385499]
[http://dx.doi.org/10.1159/000261984] [PMID: 8069883]
[http://dx.doi.org/10.1016/S0300-5712(02)00045-3] [PMID: 12554113]
[http://dx.doi.org/10.1016/j.jdent.2009.05.001] [PMID: 19497653]
[http://dx.doi.org/10.1159/000070442] [PMID: 12740541]
[http://dx.doi.org/10.1159/000315346] [PMID: 20606432]
[http://dx.doi.org/10.1111/j.1600-0722.2006.00392.x] [PMID: 17184224]
[http://dx.doi.org/10.1159/000262136] [PMID: 8850583]
[http://dx.doi.org/10.1111/j.1600-0722.2007.00493.x] [PMID: 18028054]
[http://dx.doi.org/10.4317/medoral.17680] [PMID: 22322495]
[http://dx.doi.org/10.1093/jac/dkn325] [PMID: 18703525]
[http://dx.doi.org/10.1034/j.1600-051X.2002.290705.x] [PMID: 12354086]
[http://dx.doi.org/10.1590/S1806-83242006000200015] [PMID: 16878213]
[http://dx.doi.org/10.7243/2050-120X-1-7]
[http://dx.doi.org/10.1016/S2221-1691(13)60080-5] [PMID: 23646301]
[http://dx.doi.org/10.3923/rjmp.2013.100.106]
[PMID: 3256328]
[http://dx.doi.org/10.1016/S2221-1691(12)60059-8] [PMID: 23569933]
[http://dx.doi.org/10.1016/j.jdent.2010.12.007] [PMID: 21195122]
[http://dx.doi.org/10.1016/j.anaerobe.2009.02.004] [PMID: 19285147]
[PMID: 23421308]
[http://dx.doi.org/10.1590/S1678-77572012000100007] [PMID: 22437675]
[http://dx.doi.org/10.1016/j.jep.2003.09.035] [PMID: 14698516]
[http://dx.doi.org/10.4041/kjod.2009.39.3.177]
[PMID: 12584780]
[http://dx.doi.org/10.1016/j.fitote.2015.07.016] [PMID: 26232134]
[http://dx.doi.org/10.1086/525258] [PMID: 18177225]
[http://dx.doi.org/10.4103/0973-7847.194045] [PMID: 28082798]
[PMID: 9825116]
[PMID: 10337455]
[PMID: 10994153]
[http://dx.doi.org/10.1093/jac/47.5.565] [PMID: 11328766]
[http://dx.doi.org/10.1002/ffj.1843]
[PMID: 17063641]
[PMID: 17966760]
[http://dx.doi.org/10.2174/1389557516666160211120540] [PMID: 26864553]
[PMID: 26442753]
[http://dx.doi.org/10.1055/s-0035-1545879] [PMID: 25875509]
[PMID: 733881]
[PMID: 493400]
[http://dx.doi.org/10.1186/1472-6882-11-16] [PMID: 21352539]
[PMID: 16645287]
[http://dx.doi.org/10.1021/jf0103572] [PMID: 11513714]
[http://dx.doi.org/10.1038/jid.2013.446] [PMID: 24166134]
[http://dx.doi.org//10.1016/j.det.2011.08.003] [PMID: 22117875]
[http://dx.doi.org/10.1111/j.1468-3083.2011.04416.x] [PMID: 22214317]
[http://dx.doi.org/10.1136/bmj.319.7202.79] [PMID: 10398626]
[PMID: 4193225]
[http://dx.doi.org/10.1001/archderm.1977.01640060145029] [PMID: 326197]
[PMID: 4619463]
[http://dx.doi.org/10.1111/j.1365-2133.1973.tb02978.x] [PMID: 4582719]
[http://dx.doi.org/10.1111/j.1439-0507.1979.tb01675.x] [PMID: 368628]
[http://dx.doi.org/10.1111/j.1365-2230.1986.tb00477.x] [PMID: 2948740]
[http://dx.doi.org/10.1111/j.1365-4362.1994.tb01524.x] [PMID: 8002148]
[http://dx.doi.org/10.4103/0253-7613.121378] [PMID: 24347774]
[http://dx.doi.org/10.1046/j.1472-765X.2003.01370.x] [PMID: 12859660]
[http://dx.doi.org/10.1080/10408398.2015.1087964] [PMID: 26587821]
[http://dx.doi.org/10.1590/S1984-82502013000400004]
[http://dx.doi.org/10.1016/0738-081X(95)00119-Z] [PMID: 8901410]
[http://dx.doi.org/10.1016/j.ajic.2004.07.012] [PMID: 15685130]
[http://dx.doi.org/10.1016/j.jep.2014.03.066] [PMID: 24721027]
[http://dx.doi.org/10.1111/j.1468-2494.2010.00623.x] [PMID: 21272039]
[PMID: 17101479]
[http://dx.doi.org/10.1046/j.1467-2494.2003.00183.x] [PMID: 18494899]
[http://dx.doi.org/10.1111/ics.12055] [PMID: 23614401]
[http://dx.doi.org/10.1016/0190-9622(90)70140-D] [PMID: 2142498]
[http://dx.doi.org/10.1007/s001050050105] [PMID: 7928340]
[PMID: 8740097]
[http://dx.doi.org/10.1007/s11046-006-0075-0] [PMID: 17146583]
[http://dx.doi.org/10.1111/ics.12098] [PMID: 24117781]
[http://dx.doi.org/10.1007/BF00509065] [PMID: 7165342]
[PMID: 2145499]
[http://dx.doi.org/10.4103/0378-6323.30646] [PMID: 17314442]
[http://dx.doi.org/10.1016/j.jhin.2004.01.008] [PMID: 15066738]
[http://dx.doi.org/10.1093/jac/dks501] [PMID: 23297395]
[PMID: 8195735]
[http://dx.doi.org/10.1046/j.1365-3156.1999.00396.x] [PMID: 10357864]
[http://dx.doi.org/10.1111/j.1440-0960.1992.tb00103.x] [PMID: 1303075]
[http://dx.doi.org/10.1046/j.1440-0960.2002.00590.x] [PMID: 12121393]
[http://dx.doi.org/10.1067/mjd.2002.122734] [PMID: 12451368]
[http://dx.doi.org/10.1128/CMR.19.1.50-62.2006] [PMID: 16418522]
[http://dx.doi.org/10.1080/10412905.2013.860409]
[http://dx.doi.org/10.1111/j.1472-765X.1994.tb00894.x]
[http://dx.doi.org/10.1111/j.1365-2672.1995.tb05025.x] [PMID: 7730203]
[http://dx.doi.org/10.1093/jac/35.3.421] [PMID: 7782258]
[http://dx.doi.org/10.1055/s-2000-8604] [PMID: 10985085]
[http://dx.doi.org/10.1016/S0196-6553(96)90011-5] [PMID: 8806995]
[http://dx.doi.org/10.1046/j.1365-2672.1998.00379.x] [PMID: 9633651]
[http://dx.doi.org/10.1093/jac/40.2.305] [PMID: 9302003]
[http://dx.doi.org/10.1111/j.1472-765X.1995.tb01051.x] [PMID: 7576514]
[http://dx.doi.org/10.1093/jac/45.5.639] [PMID: 10797086]
[http://dx.doi.org/10.1093/jac/42.5.591] [PMID: 9848442]
[http://dx.doi.org/10.1080/10412905.2000.9699509]
[PMID: 15813697]
[PMID: 11575735]
[http://dx.doi.org/10.1179/joc.2001.13.4.377] [PMID: 11589479]
[http://dx.doi.org/10.1179/joc.2002.14.5.465] [PMID: 12462426]
[http://dx.doi.org/10.1093/jac/dkf112] [PMID: 12161399]
[http://dx.doi.org/10.1046/j.1365-2672.2003.02059.x] [PMID: 12969301]
[http://dx.doi.org/10.1093/jac/dkg202] [PMID: 12668571]
[http://dx.doi.org/10.1046/j.1472-765X.2003.01375.x] [PMID: 12859665]
[http://dx.doi.org/10.1046/j.1365-2672.2000.00943.x] [PMID: 10735256]
[http://dx.doi.org/10.1128/AAC.46.6.1914-1920.2002] [PMID: 12019108]
[http://dx.doi.org/10.1046/j.1365-2672.2001.01406.x] [PMID: 11556915]
[http://dx.doi.org/10.1111/j.1472-765X.2008.02334.x] [PMID: 18298453]
[http://dx.doi.org/10.1097/01.ju.0000152365.43125.3b] [PMID: 15711342]
[http://dx.doi.org/10.1067/mda.2003.7] [PMID: 12601337]
[http://dx.doi.org/10.1016/S0002-9343(02)01054-9] [PMID: 12113866]
[http://dx.doi.org/10.1097/01.ju.0000155596.98780.82] [PMID: 15758783]
[http://dx.doi.org/10.1067/mda.2003.8] [PMID: 12601338]
[http://dx.doi.org/10.1016/j.jiph.2009.08.003] [PMID: 20701869]
[PMID: 21466767]
[http://dx.doi.org/10.1016/j.indcrop.2013.07.003]
[http://dx.doi.org/10.2147/RRU.S133538] [PMID: 28491861]
[http://dx.doi.org/10.1016/S0094-0143(05)70212-3] [PMID: 10584612]
[http://dx.doi.org/10.1016/j.ucl.2015.05.010] [PMID: 26475944]
[http://dx.doi.org/10.1016/j.lpm.2006.12.033] [PMID: 17544611]
[http://dx.doi.org/10.1007/s00345-013-1091-6] [PMID: 23633128]
[http://dx.doi.org/10.1038/nrurol.2015.199] [PMID: 26334085]
[PMID: 18950249]
[http://dx.doi.org/10.1136/bmj.c279] [PMID: 20139217]
[http://dx.doi.org/10.3390/pathogens5020036] [PMID: 27092529]
[http://dx.doi.org/10.5301/uro.5000186] [PMID: 27405343]
[http://dx.doi.org/10.1086/386328] [PMID: 15156480]
[http://dx.doi.org/10.9755/ejfa.v26i7.16404]
[http://dx.doi.org/10.1016/S0022-5347(17)50751-X] [PMID: 6368872]
[PMID: 3063927]
[http://dx.doi.org/10.1128/AAC.33.1.92] [PMID: 2653218]
[http://dx.doi.org/10.1056/NEJM199105303242214] [PMID: 1674106]
[http://dx.doi.org/10.1111/j.1574-695X.2000.tb01537.x] [PMID: 11118911]
[http://dx.doi.org/10.1089/jmf.2005.8.36] [PMID: 15857207]
[http://dx.doi.org/10.1016/j.foodcont.2011.02.024]
[http://dx.doi.org/10.1016/j.foodcont.2011.08.010]
[http://dx.doi.org/10.1016/j.foodres.2011.06.049]
[http://dx.doi.org/10.1007/s10068-011-0181-8]
[http://dx.doi.org/10.1016/j.jff.2015.05.016] [PMID: 26613004]
[http://dx.doi.org/10.1016/j.juro.2017.03.078] [PMID: 28288837]
[http://dx.doi.org/10.1590/1516-3180.20131315T1] [PMID: 24310806]
[http://dx.doi.org/10.1021/jf204912u] [PMID: 22439747]
[http://dx.doi.org/10.4172/2327-5162.1000107]
[http://dx.doi.org/10.1021/jf903710y] [PMID: 20058864]
[http://dx.doi.org/10.1111/j.1750-3841.2012.02788.x] [PMID: 22747948]
[PMID: 28165546]
[PMID: 25635978]
[PMID: 28051247]
[http://dx.doi.org/10.1186/1471-2490-13-28] [PMID: 23738867]
[http://dx.doi.org/10.3390/molecules190914948] [PMID: 25237750]
[http://dx.doi.org/10.1186/1472-6882-13-90] [PMID: 23622254]
[http://dx.doi.org/10.1016/S0011-393X(05)80204-8]
[http://dx.doi.org/10.1177/1091581813507721] [PMID: 24296864]
[PMID: 12522584]
[http://dx.doi.org/10.1016/j.hermed.2017.03.006]
[http://dx.doi.org/10.1185/030079907X233089] [PMID: 17723159]
[http://dx.doi.org/10.1016/j.foodcont.2008.03.007]
[http://dx.doi.org/10.3389/fcimb.2012.00053] [PMID: 22919644]
[http://dx.doi.org/10.1016/j.foodchem.2017.03.150] [PMID: 28490082]
[http://dx.doi.org/10.1016/j.jep.2008.07.036] [PMID: 18725278]
[http://dx.doi.org/10.1002/(SICI)1099-1573(199811)12:7<494:AID-PTR340>3.0.CO;2-N]
[http://dx.doi.org/10.1016/S0015-6264(64)80192-9]
[http://dx.doi.org/10.1177/1099800411412767] [PMID: 21708892]
[http://dx.doi.org/10.1890/1540-9295(2003)001[0421:UECTDP]2.0.CO;2]
[http://dx.doi.org/10.1016/j.jep.2010.03.034] [PMID: 20371284]
[http://dx.doi.org/10.1016/j.fitote.2014.01.024] [PMID: 24508861]
[http://dx.doi.org/10.1016/j.arabjc.2015.04.021]
[http://dx.doi.org/10.1016/j.fitote.2017.02.008] [PMID: 28223069]
[PMID: 25859123]
[http://dx.doi.org/10.1007/s00253-012-4117-x] [PMID: 22622837]
[http://dx.doi.org/10.1016/j.jbiotec.2011.07.001] [PMID: 21763730]
[http://dx.doi.org/10.1128/IAI.73.6.3197-3209.2005] [PMID: 15908344]
[http://dx.doi.org/10.1016/j.fitote.2018.07.002] [PMID: 29981875]
[http://dx.doi.org/10.1080/0735-260291044269]
[http://dx.doi.org/10.1016/S0167-7799(02)02080-2] [PMID: 12443874]
[http://dx.doi.org/10.1046/j.1439-0507.2003.00951.x] [PMID: 15078424]
[http://dx.doi.org/10.1073/pnas.030540597] [PMID: 10677479]
[http://dx.doi.org/10.1016/j.ejphar.2015.05.068] [PMID: 26092760]
[http://dx.doi.org/10.1016/j.phymed.2008.06.008] [PMID: 18599280]
[http://dx.doi.org/10.3109/1040841X.2013.763219] [PMID: 23445470]
[http://dx.doi.org/10.1128/AAC.38.9.2187] [PMID: 7811043]
[http://dx.doi.org/10.1128/AAC.49.1.431-433.2005] [PMID: 15616328]
[http://dx.doi.org/10.2174/157340608784325098] [PMID: 18473917]
[http://dx.doi.org/10.1139/Y07-106] [PMID: 18066112]