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Mini-Reviews in Organic Chemistry

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ISSN (Online): 1875-6298

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Review Article

Synthesis of Spiro Compounds Based on 1H-Pyrrole-2,3-Diones

Author(s): Valeriya V. Konovalova* and Andrey N. Maslivets

Volume 16, Issue 2, 2019

Page: [173 - 192] Pages: 20

DOI: 10.2174/1570193X15666180712115204

Price: $65

Abstract

Polycyclic structures fused at a central carbon are of great interest due to their appealing conformational features and their structural implications in biological systems. Although progress in the development of synthetic methodologies towards such structures has been impressive, the stereoselective construction of such quaternary stereocentres remains a significant challenge in the total synthesis of natural products. This review summarises a series of studies on the reactions of 1H-pyrrole-2,3- diones with nucleophiles and highlights the progress in the formation of new polyheterocyclic compounds with concomitant formation of the quaternary spiro centre.

Keywords: Spiro compounds, spiro heterocyclisation, 1H-pyrrole-2, 3-diones, binucleophiles, heterocycles, benzoxazine fragment.

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Graphical Abstract

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