Generic placeholder image

Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

4-Formylpyrazoles: Applications in Organic Synthesis

Author(s): Renu Bala, Poonam Kumari, Sumit Sood and Karan Singh*

Volume 16, Issue 2, 2019

Page: [193 - 203] Pages: 11

DOI: 10.2174/1570193X15666180712121527

Price: $65

Abstract

4-Formylpyrazoles are useful building blocks in organic synthesis. This review focuses on the applications of 4-formylpyrazoles to generate a large variety of organic compounds and heterocycles such as Schiff bases, pyrazolylpyrazolines, pyrazoloquinolinones, 4H-pyrazolopyran, pyrazolylbenzoxazole, pyrazolothiadiazepines, pyrazolyloxazolone, pyrazolyloxadiazolines, pyrazolylthiadiazolines, imidazolylpyrazoles, pyrazolopyridines, chromenopyrazolones, thiopyranothiazolylpyrazoles and many others. Many of these molecules exhibit excellent biological activities.

Keywords: Schiff bases, pyrazolylpyrazolines, pyrazoloquinolinones, 4H-pyrazolopyran, pyrazolylbenzoxazole, pyrazolothiadiazepines, pyrazolyloxazolone, pyrazolyloxadiazolines, pyrazolylthiadiazolines.

« Previous
Graphical Abstract

[1]
Sullivan, T.J.; Truglio, J.J.; Boyne, M.E.; Novichenok, P.; Zhang, X.; Stratton, C.F.; Li, H.J.; Kaur, T.; Amin, A.; Johnson, F.; Slayden, R.A.; Kisker, C.; Tonge, P.J. High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. ACS Chem. Biol., 2006, 1, 43-53.
[2]
Liu, X.H.; Cui, P.; Song, B.A.; Bhadury, P.S.; Zhu, H.L.; Wang, S.F. Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl) ethanone oxime ester derivatives. Bioorg. Med. Chem., 2008, 16, 4075-4082.
[3]
Foks, H.; Pancechowska-Ksepko, D.; Kedzia, A.; Zwolska, Z.; Janowiec, M.; Augustynowicz-Kopec, E. Synthesis and antibacterial activity of 1H-pyrazolo[3,4-b]pyrazine and -pyridine derivatives. II Farmaco, 2005, 60, 513-517.
[4]
Gilbert, A.M.; Failli, A.; Shumsky, J.; Yang, Y.; Severin, A.; Singh, G.; Hu, W.; Keeney, D.; Petersen, P.J.; Katz, A.H. Pyrazolidine-3,5-diones and 5-Hydroxy-1H-pyrazol-3(2H)-ones, Inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase. J. Med. Chem., 2006, 49, 6027-6036.
[5]
Shamroukh, A.H.; Zaki, M.E.A.; Morsy, E.M.H.; Abdel-Motti, F.M.; AbdelMegeid, F.M.E. Synthesis, isomerization and antimicrobial evaluation of some pyrazolopyranotriazolopyrimidine derivatives. Arch. Pharm. Chem. Life Sci., 2007, 340, 345-351.
[6]
Prakash, O.; Kumar, R.; Parkash, V. Synthesis and antifungal activity of some new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl)chrom-ones. Eur. J. Med. Chem., 2008, 43, 435-440.
[7]
Prakash, O.; Pundeer, R.; Ranjan, P.; Pannu, K.; Dhingra, Y.; Aneja, K.R. Synthesis and antibacterial activity of 1,3-diaryl-4-cyanopyrazoles. Indian J. Chem., 2009, 48B, 563-568.
[8]
Magedov, I.V.; Manpadi, M. Van slambrouck, S.; Steelant, W.F.A.; Rozhkova, E.; Przheval'skii, N.M.; Rogelj, S.; Kornienko, A. Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. J. Med. Chem., 2007, 50, 5183-5192.
[9]
Tewari, A.K.; Srivastava, P.; Singh, V.P.; Singh, A.; Goel, R.K.; Mohan, C.G. Novel anti-inflammatory agents based on pyrazole based dimeric compounds; design, synthesis, docking and in vivo activity. Chem. Pharm. Bull. (Tokyo), 2010, 58, 634-638.
[10]
Szabo, G.; Fischer, J.; Kis-Varga, A.; Gyires, K. New celecoxib derivatives as anti-inflammatory agents. J. Med. Chem., 2008, 51, 142-147.
[11]
Benaamane, N.; Nedjar-Kolli, B.; Bentarzi, Y.; Hammal, L.; Geronikaki, A.; Eleftheriou, P.; Langunin, A. Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems. Bioorg. Med. Chem., 2008, 6, 3059-3066.
[12]
Rosati, O.; Curini, M.; Marcotullio, M.C.; Macchiarulo, A.; Perfumi, M.; Mattioli, L.; Rismondo, F.; Cravotto, G. Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives. Bioorg. Med. Chem., 2007, 15, 3463-3473.
[13]
Palaske, E.; Aytemir, M.; Uzbay, I.T.; Erol, D. Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines. Eur. J. Med. Chem., 2001, 36, 539-543.
[14]
Rajendra, P.Y.; Lakshmana, R.A.; Prasoona, L.; Murali, K.; Ravi, K.P. Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2"'-hydroxynaphthalen-1"'-yl)-1,5-diphenyl-2-pyrazolines. Bioorg. Med. Chem. Lett., 2005, 15, 5030-5034.
[15]
Ozdemir, Z.; Kandilici, H.B.; Gumusel, B.; Calis, U.; Bilgin, A.A. Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives. Eur. J. Med. Chem., 2007, 42, 373-379.
[16]
Ruhogluo, O.; Ozdemir, Z.; Calis, U.; Gumusel, B.; Bilgin, A.A. Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines. Arzneimittelforschung, 2005, 55, 431-436.
[17]
Sener, A.; Kasimogullari, R.; Sener, M.K.; Bildirici, I.; Akcamur, Y. Studies on the reactions of cyclic oxalyl compounds with hydrazines or hydrazones: Synthesis and reactions of 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid. J. Heterocycl. Chem., 2002, 39, 869-875.
[18]
Wachter, G.A.; Hartmann, R.W.; Sergejew, T.; Grun, G.L.; Ledergerber, D. Tetrahydronaphthalenes:Influence of heterocyclic substituents on inhibition of steroidogenic enzymes P450 arom and P450 17. J. Med. Chem., 1996, 39, 834-841.
[19]
Chaudhry, F.; Naureen, S.; Huma, R.; Shaukat, A.; Al-Rashida, M.; Asif, N.; Ashraf, M.; Munawar, M.; Khan, M.A. In search of new α-glucosidase inhibitors: Imidazolylpyrazole derivatives. Bioorg. Chem., 2017, 71, 102-109.
[20]
Palomer, A.; Cabre, F.; Pascual, J.; Campos, J.; Trujillo, M.A.; Entrena, A.; Gallo, M.A.; Garcia, L.; Mauleon, D.; Espinosa, A. Identification of novel cyclooxygenages-2 selective inhibitors using pharmacophoremodels. J. Med. Chem., 2002, 45, 1402-1411.
[21]
Kucukguzel, S.G.; Rollas, S.; Erdeniz, H.; Kiraz, M.; Ekinci, A.C.; Vidin, A. Synthesis characterization and pharmacological properties of some 4-arylhydrazono-2-pyrazoline-5-one derivatives obtained from heterocyclic amines. Eur. J. Med. Chem., 2000, 35, 761-771.
[22]
Genin, M.J.; Allwine, D.A.; Anderson, D.J.; Barbachyn, M.R.; Emmert, D.E.; Garmon, S.A.; Graber, D.R. Substituent effect on the antibacterial activity of nitrogen- carbon- linked (Azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenza and Moraxella catarrhalis. J. Med. Chem., 2000, 43, 953-970.
[23]
Sridhar, R.; Perumal, P.T.; Etti, S.; Shanmugam, G.; Ponnuswamy, M.N.; Prabavathy, V.R.; Mathivanan, N. Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates. Bioorg. Med. Chem. Lett., 2004, 14, 6035-6040.
[24]
Bekhit, A.A.; Fahmy, H.T.Y.; Rostom, S.A.F.; Baraka, A.M. Design and synthesis of some substituted 1H-pyrazolyl-thiazolo[4,5-d]pyrimidines as anti-inflammatory-antimicrobial agents. Eur. J. Med. Chem., 2003, 8, 27-36.
[25]
Bekhit, A.A.; Fahmy, H.T.Y. Design and synthesis of some substituted 1H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents. Arch. Pharm. Pharm. Med. Chem, 2003, 336, 111-118.
[26]
Bekhit, A.A.; Ashour, H.M.; Abdel Ghany, Y.S. Bekhit, Ael-D.; Baraka, A. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents. Eur. J. Med. Chem., 2008, 43, 456-463.
[27]
Bekhit, A.A.; Ashour, H.M.A.; Guemei, A. Novel pyrazole derivatives as potential promising anti-inflammatory antimicrobial agents. Arch. Pharm. Chem. Life, 2005, 338, 167-174.
[28]
Sharma, P.K.; Kumar, S.; Kumar, P.; Kaushik, P.; Kaushik, D.; Dhingra, Y.; Aneja, K.R. Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory-antimicrobial agents. Eur. J. Med. Chem., 2010, 45, 2650-2655.
[29]
Thumar, N.J.; Patel, M.P. Synthesis and in vitro antimicrobial evaluation of 4H-pyrazolopyran, benzopyran and napthopyran derivatives of 1H-pyrazole. ARKIVOC; Xiii, 2009, pp. 363-380.
[30]
Khloya, P.; Kumar, P.; Mittal, A.; Aggarwal, N.K.; Sharma, P.K. Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents. Org. Med. Chem. Lett., 2013, 3, 1-7.
[31]
Felding, J.; Kristensen, J.; Bjerregaard, T.; Sander, L.; Vedso, P.; Begtrup, M. Synthesis of 4-substituted 1-(benzyloxy)pyrazoles via iodine-magnesium exchange of 1-(benzyloxy)-4-iodopyrazole. J. Org. Chem., 1999, 64, 4196-4198.
[32]
Abdel-Wahab, B.F.; Khidre, R.E.; Farahatd, A.A. Pyrazole-3(4)-carbaldehyde: Synthesis, reactions and biological activity. ARKIVOC, 2011, i, 196-245.
[33]
Balle, T.; Vedso, P.; Begtrup, M. Regioselective introduction of electrophiles in the 4-position of 1-hydroxypyrazole via bromine-lithium exchange. J. Org. Chem., 1999, 64, 5366-5370.
[34]
Stensbol, T.B.; Uhlmann, P.; Morel, S.; Eriksen, B.L.; Felding, J.; Kromann, H.; Hermit, M.B.; Greenwood, J.R.; Brauner-Osborne, H.; Madsen, U.; Junager, F.; Krogsggard-Larsen, P.; Begtrup, M.; Vedso, P. Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology. J. Med. Chem., 2002, 45, 19-31.
[35]
Vedso, P.; Begtrup, M. Synthesis of 5-substituted 1-hydroxypyrazoles through directed lithiation of 1-(benzyloxy) pyrazole. J. Org. Chem., 1995, 60, 4995-4998.
[36]
Arbaciauskiene, E.; Kazlauskas, K.; Miasojedovas, A.; Jursenas, S.; Jankauskas, V.; Holzer, W.; Getautis, V.; Sackus, A. Pyrazolyl-substituted polyconjugated molecules for optoelectronic applications. Dyes Pigments, 2010, 85, 79-85.
[37]
Arbaciauskiene, E.; Kazlauskas, K.; Miasojedovas, A.; Jursenas, S.; Jankauskas, V.; Holzer, W.; Getautis, V.; Sackus, A. Multifunctional polyconjugated molecules with carbazolyl and pyrazolyl moieties for optoelectronic applications. Synth. Met., 2010, 160, 490-498.
[38]
Lidia, D.L.; Giampaolo, G.; Simonetta, M.; Andrea, P. A mild procedure for the preparation of 3-aryl-4-formylpyrazoles. Synlett, 2004, 13, 2299-2302.
[39]
Vera-DiVaio, M.A.F.; Freitas, A.C.C.; Castro, H.C.; de Albuquerque, S.; Cabral, L.M.; Rodrigues, C.R.; Albuquerque, M.G.; Martins, R.C.A.; Henriques, M.G.M.O. Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series. Bioorg. Med. Chem., 2009, 17, 295-302.
[40]
Luo, Y.; Zhong, P.; Zhang, X.H.; Lin, Q.L.; Chen, Y.N. Formylation of N-arylpyrazole containing active amino group using Vilsmeier-Hacck reaction. Chin. Chem. Lett., 2008, 19, 383.
[41]
Nagamallu, R.; Srinivasan, B.; Ningappa, M.B.; Kariyappa, A.K. Synthesis of novel coumarin appended bis(formylpyrazole) derivatives: Studies on their antimicrobial and antioxidant activities. Bioorg. Med. Chem. Lett., 2016, 26, 690-694.
[42]
Vaarla, K.; Kesharwani, R.K.; Santosh, K.; Rao, R.; Kotamraju, S.; Toopurani, M.K. Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes. Bioorg. Med. Chem. Lett., 2015, 25, 5797-5803.
[43]
Sharma, P.K.; Singh, K.; Dhawan, S.N.; Singh, S.P. Synthesis and characterization of some novel 4-formyl pyrazolylthiazoles of potential medicinal interest using Vilsmeier-Haack reaction. Indian J. Chem., 2002, 41A, 2071-2075.
[44]
Singh, K.; Ralhan, S.; Sharma, P.K.; Dhawan, S.N. Vilsmeier-Haack reaction on hydrazones: A convenient synthesis of 4-formylpyrazoles. J. Chem. Res., 2005, , 316-318.
[45]
Dai, H.; Yu, H-B.; Liu, J-B.; Li, Y-Q.; Qui, X.; Zhang, X.; Qin, Z-F.; Wang, T-T.; Fang, J-X. Synthesis and bioactivities of novel trifluoromethylated pyrazole oxime ether derivatives containing a pyridyl moiety. ARKIVOC, 2009, vii, 126-142.
[46]
Arbaciauskiene, E.; Martynaitis, V.; Krikstolaityte, S.; Holzer, W.; Sackusa, A. Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalysed cross-coupling reactions. ARKIVOC, 2011, xi, 1-21.
[47]
Kucukguzel, G.; Kocatepe, A.; Clercq, E.D.; Sahin, F.; Gulluce, M. Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide. Eur. J. Med. Chem., 2006, 41, 353-359.
[48]
Kalsi, R.; Shrimali, M.; Bhalla, T.N.; Barthwal, J.P. Synthesis and anti-inflammatory activity of indolylazetidinones. Indian J. Pharm. Sci., 1990, 52, 129-134.
[49]
Patole, J.; Shingnapurkar, D.; Padhye, S.; Ratledge, C. Schiffs base conjugates of p-aminosalicyclic acid as antimycobacterial agents. Bioorg. Med. Chem. Lett., 2006, 16, 1514-1517.
[50]
Hearn, M.J.; Cynamon, M.H. Design and synthesis of antituberculars: Preparation and evaluation against mycobacterium tuberculosis of an isoniazid Schiff base. J. Antimicrob. Chemother., 2004, 53, 185-191.
[51]
Ren, S.; Wang, R.; Komatsu, K.; Bonaz-Krause, P.; Zyrianov, Y.; McKenna, C.E.; Cipke, C.; Tokes, Z.A.; Lien, E.J. Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of new schiff bases of hydroxysemicarbazide as potential antitumor agents. J. Med. Chem., 2002, 45, 410-419.
[52]
Bhandari, S.V.; Bothara, K.G.; Raut, M.K.; Patil, A.A.; Sarkate, A.P.; Mokale, V.J. Synthesis and evaluation of anti-inflammatory, analgesic and ulcerogenicity studies of novel S-substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of diclofenac acid as nonulcerogenic derivatives. Bioorg. Med. Chem., 2008, 16, 1822-1831.
[53]
Sridhar, S.K.; Pandeya, S.N.; Stables, J.P.; Ramesh, A. Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. Eur. J. Pharm. Sci., 2002, 16, 129-132.
[54]
Kaplan, J.P.; Raizon, B.M.; Desarmenien, M.; Feltz, P.; Headley, P.M.; Worms, P.; Lloyd, K.G.; Bartholini, G. New anticonvulsants: Schiff bases of I3-aminobutyric acid and I3-aminobutyramide. J. Med. Chem., 1980, 23, 702-704.
[55]
Shi, L.; Ge, H.M.; Tan, S.H.; Li, H.Q.; Song, Y.C.; Zhu, H.L.; Tan, R.X. Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. Eur. J. Med. Chem., 2007, 42, 558-564.
[56]
Malladi, S.; Isloor, A.M.; Isloor, S.; Akhila, D.S.; Hoong-Kun, F. Synthesis, characterization and antibacterial activity of some new pyrazole based Schiff-bases. Arab. J. Chem., 2013, 6, 335-340.
[57]
Vora, J.J.; Vasava, S.B.; Parmar, K.C.; Chauhan, S.K.; Sharma, S.S. Synthesis, spectral and microbial studies of some novel Schiff base derivatives of 4-methylpyridin-2-amine. E-J. Chem., 2009, 6, 1205-1210.
[58]
Sharma, K.; Jain, R. Synthesis, reactions and anthelmintic activity of 1-[benzimidazol-2-yl]-4-formyl-3-[2'(-substituted phenyl) indole-3-yl] pyrazoles. Indian J. Chem., 2012, 51B, 1462-1469.
[59]
Abd El-Wahab, A.H.F.; Al-Fifi, Z.I.A.; Bedair, A.H.; Ali, F.M.; Halawa, A.H.A.; El-Agrody, A.M. Synthesis, reactions and biological evaluation of some new naphtho[2,1-b]furan derivatives bearing a pyrazole nucleus. Molecules, 2011, 16, 307-318.
[60]
Sharma, P.K.; Kumar, S.; Kumar, P.; Kaushik, P.; Kaushik, D.; Dhingra, Y.; Aneja, K.R. Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory-antimicrobial agents. Eur. J. Med. Chem., 2010, 45, 2650-2655.
[61]
Khloya, P.; Kumar, P.; Mittal, A.; Aggarwal, N.K.; Sharma, P.K. Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents. Org. Med. Chem. Lett., 2013, 3, 9.
[62]
Maurer, F.; Fuchs, R.; Konze, J.; Turberg, A.; Erdelen, C. Substituted 4-pyrazolyl pyrazonlines used for pest control. US 7345080 B2 2008.
[63]
Khloya, P.; Ceruso, M.; Ram, S.; Supuran, C.T.; Sharma, P.K. Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII. Bioorg. Med. Chem. Lett., 2015, 25, 3208-3212.
[64]
Shelke, S.N.; Dalvi, N.R.; Kale, S.B.; Mor, M.S.; Karale, B.K. Environmentally being synthesis of fluorinated pyrazolone derivatives and their antimicrobial activity. Indian J. Chem., 2007, 46B, 1174-1178.
[65]
Siddiqui, Z.N.; Praveen, S.; Mohammed, M.T.N. Synthesis and antibacterial evaluation of novel heterocycles from 5-chloro-3-methyl-1-phenylpyrazole-4-carbaldehyde. Indian J. Chem., 2011, 50B, 910-917.
[66]
Ferlin, M.G.; Chiarelotto, G.; Acqua, S.D.; Maciocco, E.; Mascia, M.P.; Pisu, M.G.; Biggio, G. Novel anellated pyrazoloquinolin-3-ones: Synthesis and in vitro BZR activity. Bioorg. Med. Chem., 2005, 13, 3531-3541.
[67]
Thumar, N.J.; Patel, M.P. Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole. Saudi Pharm. J., 2011, 19, 75-83.
[68]
Chang, W.; Sun, Y.; Huang, Y. One-pot green synthesis of benzoxazole derivatives through molecular sieve-catalyzed oxidative cyclization reaction. Heteroatom Chem., 2017, 28, e21360.
[69]
Prakash, O.; Pannu, K.; Kumar, A. Synthesis of some new 2-(3-aryl-1-phenyl-4-pyrazolyl)-benzoxazoles using hypervalent iodine mediated oxidative cyclization of Schiff's bases. Molecules, 2006, 11, 43-48.
[70]
Gupta, M.; Paul, S.; Gupta, R. Microwave-assisted one-pot synthesis of antifungal active 1-substituted-3,7-dialkyl/aryl-4H-pyrazolo [4,5-f]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines using solid support. Indian J. Chem., 2009, 48B, 460-466.
[71]
Argade, N.D.; Kalrale, B.K.; Gill, C.H. Microwave assisted improved method for the synthesis of pyrazole containing 2,4-disubstituted oxazole-5-one and their antimicrobial activity. E-J. Chem., 2008, 5, 120-129.
[72]
Zoghbi, M.; Warkentin, J. Spiro-fused β-lactam oxadiazolines by formal [2+2] cycloaddition of 2-imino- I"3-1,3,4-oxadiazolines to ketenes. Can. J. Chem., 1993, 71, 912-918.
[73]
Abadi, A.H.; Eissa, A.A.H.; Hassan, G.S. Synthesis of novel 1,3,4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents. Chem. Pharm. Bull. (Tokyo), 2003, 51, 838-844.
[74]
Fatondji, H.R.; Gbaguidi, F.; Kpoviessi, S.; Bero, J.; Hannaert, V.; Quetin-Leclercq, J.; Poupaert, J.; Moudachirou, M.; Accrombessi, G.C. Synthesis, characterization and trypanocidal activity of some aromatic thiosemicarbazones and their 1, 3, 4-thiadiazolines derivatives. Afr. J. Pure Appl. Chem., 2011, 5, 59-64.
[75]
Visagaperumal, D.; Kumar, R.J.; Vijayaraj, R.; Anbalagan, N. Microwave induced synthesis of some new 3- substituted-1, 3-thiazolidin-4-ones for their potent anti-microbial and anti-tubercular activities. Int. J. Comput. Appl., 2009, 1, 1048-1051.
[76]
Abdel-Wahab, B.F.; Khidre, R.E. Azolylimidazoles: Synthetic strategies and medicinal applications. Turk. J. Chem., 2014, 38, 1-27.
[77]
Metwally, N.H.; Badawy, M.A.; Okpy, D.S. Synthesis and Anticancer activity of some new thiopyrano[2,3-d] thiazoles incorporating pyrazole moiety. Chem. Pharm. Bull. (Tokyo), 2015, 63, 495-03.
[78]
Metwally, N.H. A simple green synthesis of (Z)-5-arylmethylene-4-thioxothiazolidines and thiopyrano[2,3-d]thiazolidine-2-thiones in PEG-400 under catalyst-free conditions. J. Sulfur Chem., 2014, 35, 528-537.
[79]
Li, H.; Liu, C.; Zhang, Y.; Sun, Y.; Wang, B.; Liu, W. Green method for the synthesis of chromeno[2,3-c]pyrazol-4(1H)-ones through ionic liquid promoted directed annulation of 5-(aryloxy)-1H-pyrazole-4-carbaldehydes in aqueous media. Org. Lett., 2015, 17, 932-935.
[80]
Palka, B.; Di Capua, A.; Anzini, M.; VilkauskaitA(c), G.; Sackus, A.; Holzer, W. Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines-sequential versus multicomponent reaction approach. Beilstein J. Org. Chem., 2014, 10, 1759-1764.

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version311msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[17:52:48] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[17:52:48] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[17:52:48] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (130ms)time
  • Application (182ms)time
  • 1 x Application (58.35%)
    182ms
    1 x Booting (41.64%)
    130ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    36 statements were executed, 4 of which were duplicates, 32 unique. Show only duplicated85.49ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51435153','',1,1739987568,1739987568) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739987568
      1.76msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51435153','/article/91662',1,1739987568,1739987568)
      180μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) limit 1
      13.23msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51435153
      • 1: 51435153
      • 2: 51435153
      • 3: 51435153
      • 4: 51435153
      • 5: 51435153
      • 6: 51435153
      • 7: 51435153
      • 8: 51435153
      • 9: 51435153
      • 10: 51435153
      • 11: 51435153
      • 12: 51435153
      • 13: 51435153
      • 14: 51435153
      • 15: 51435153
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=91662
      740μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 45 limit 1
      800μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 45
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and sj.journal_id!=45 group by `j`.`nid`) as `aggregate_table`
      590μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and sj.journal_id!=45 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      500μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      780μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=45) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      730μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '91662'
      2.32msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 91662
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '91662'
      4.81msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 91662
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '91662' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3.95msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 91662
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      250μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      480μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 45 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      25.2msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 45 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      6.49msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 45 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      5.18msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 91662 limit 1
      270μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 91662
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 91662 and content_type = 'article' order by status desc limit 1
      300μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 163719 limit 1
      220μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 163719
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      330μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'MROC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      370μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: MROC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '91662' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      500μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '8789' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      430μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2516' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      380μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2516) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2516) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2516)
      7.4msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 8789) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 8789) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 8789)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 91662) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 91662) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 91662)
      550μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '193' and is_uploaded = 1 and issue_id = 8789 order by cast(first_page as SIGNED) desc limit 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 193
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '203' and is_uploaded = 1 and issue_id = 8789 order by cast(first_page as SIGNED) asc limit 1
      390μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 203
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      150μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 91662 limit 1
      2.42msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 91662
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 45 and `b`.`banner_from_date` <= 1739987568 and `b`.`banner_to_date` >= 1739987568 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.14msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 45
      • 3: 1739987568
      • 4: 1739987568
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 45 and `b`.`banner_from_date` <= 1739987568 and `b`.`banner_to_date` >= 1739987568 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.18msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 45
      • 3: 1739987568
      • 4: 1739987568
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='39a9b4417a53d86e2ece308a17ec3ece'
      240μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        YHjxQ6aZe47IranVHAqYARgeOLtnlCQPOKWSqxdA
        uc_cart_id
        39a9b4417a53d86e2ece308a17ec3ece
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/91662" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/91662
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 17:52:48 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ii90Uzlka1p2TDd6NDBaZDBZbmlrV2c9PSIsInZhbHVlIjoiNTU0KzRHY2J6bE4zNWRMcXNJV3pVblk2T0pFaVBWeDJ5N1ZBQVU1V28xSmZxdHdhSEJaT1RYVlFHTkt1TFdSWHVLSFFiR0FLVHBkQThOMVRxSG1PTWJrMmhudjNsbU54K0h6dEpFeTQ1ZHphMVlRWXBjeko5UU02Z2tKclZlT0kiLCJtYWMiOiI5OWU2MGZjMTA4MTk5ZTU2MGYzN2JiYTZhMzk1MWRiZDk4YTY3ZDRkYTJiYjlhMzYwYmZkMjRhYmIyY2Q1NGM3IiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 05:52:48 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ii90Uzlka1p2TDd6NDBaZDBZbmlrV2c9PSIsInZhbHVlIjoiNTU0KzRHY2J6bE4zNWRMcXNJV3pVblk2T0pFaVBWeDJ5N1ZBQVU1V28xSmZxdHdhSEJaT1RYVlFHTkt1TFdSWHVLSFFiR" 1 => "alphaeurekaselectnet_session=eyJpdiI6InRIcUFWNmJYZlhObitPajY2QWxsUnc9PSIsInZhbHVlIjoiWTFMajlpMk1VSGlVNS9KVllPZ21hT0JHUXVxMUhJNk5jNEdmWk1ndGc1Q1MrdHpyelVnMDFMMWcvRU1pUlZ5STBGSzVNZk9WYUVNOC92c21RcnRuemxtOHdwTXljTUgrb2xBdFVlSnVOMk5MV1lFTmppRWFRV3VaQk1CbkVYS1UiLCJtYWMiOiJlNWViOWVhOGRjZTkyZDg3MTk1YmYxNTRkOGMwMjRkMDA4Njk3NmQzZmFhNDg4NzAzZTc5NGExZGNhOTBkNWIzIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InRIcUFWNmJYZlhObitPajY2QWxsUnc9PSIsInZhbHVlIjoiWTFMajlpMk1VSGlVNS9KVllPZ21hT0JHUXVxMUhJNk5jNEdmWk1ndGc1Q1MrdHpyelVnMDFMMWc" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ii90Uzlka1p2TDd6NDBaZDBZbmlrV2c9PSIsInZhbHVlIjoiNTU0KzRHY2J6bE4zNWRMcXNJV3pVblk2T0pFaVBWeDJ5N1ZBQVU1V28xSmZxdHdhSEJaT1RYVlFHTkt1TFdSWHVLSFFiR0FLVHBkQThOMVRxSG1PTWJrMmhudjNsbU54K0h6dEpFeTQ1ZHphMVlRWXBjeko5UU02Z2tKclZlT0kiLCJtYWMiOiI5OWU2MGZjMTA4MTk5ZTU2MGYzN2JiYTZhMzk1MWRiZDk4YTY3ZDRkYTJiYjlhMzYwYmZkMjRhYmIyY2Q1NGM3IiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 05:52:48 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ii90Uzlka1p2TDd6NDBaZDBZbmlrV2c9PSIsInZhbHVlIjoiNTU0KzRHY2J6bE4zNWRMcXNJV3pVblk2T0pFaVBWeDJ5N1ZBQVU1V28xSmZxdHdhSEJaT1RYVlFHTkt1TFdSWHVLSFFiR" 1 => "alphaeurekaselectnet_session=eyJpdiI6InRIcUFWNmJYZlhObitPajY2QWxsUnc9PSIsInZhbHVlIjoiWTFMajlpMk1VSGlVNS9KVllPZ21hT0JHUXVxMUhJNk5jNEdmWk1ndGc1Q1MrdHpyelVnMDFMMWcvRU1pUlZ5STBGSzVNZk9WYUVNOC92c21RcnRuemxtOHdwTXljTUgrb2xBdFVlSnVOMk5MV1lFTmppRWFRV3VaQk1CbkVYS1UiLCJtYWMiOiJlNWViOWVhOGRjZTkyZDg3MTk1YmYxNTRkOGMwMjRkMDA4Njk3NmQzZmFhNDg4NzAzZTc5NGExZGNhOTBkNWIzIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InRIcUFWNmJYZlhObitPajY2QWxsUnc9PSIsInZhbHVlIjoiWTFMajlpMk1VSGlVNS9KVllPZ21hT0JHUXVxMUhJNk5jNEdmWk1ndGc1Q1MrdHpyelVnMDFMMWc" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "YHjxQ6aZe47IranVHAqYARgeOLtnlCQPOKWSqxdA" "uc_cart_id" => "39a9b4417a53d86e2ece308a17ec3ece" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/91662" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 17:52:48GET/article/91662314361