Abstract
Background: Curcumin, principal constituent extracted from dried rhizomes of Curcuma longa L., is a hydrophobic polyphenol meant to cure chronic malignancies like rheumatoid arthritis, Alzheimer’s, Inflammatory bowel disease and many common ailments related to colon, lung, stomach and skin. The objective of this review is to study the synergistic effect of curcumin.
Methods: Current prose emphasizes the synergistic effect of curcumin as a part of cancer treatment and other ailments have been identified and reviewed with particular emphasis on their scientific impact and novelty.
Results: A number of synergistic combinations have emerged with the growth of biological data sets that can prove to be useful for the pharmaceutical industry.
Conclusion: This present review will be help the researchers and industries in drug development as a new paradigm of drug discovery.
Keywords: Curcumin, Curcuma longa L., combination therapy, synergism, metastasis, cardioprotective.
Graphical Abstract
[http://dx.doi.org/10.1038/nrd1609] [PMID: 15688074]
[http://dx.doi.org/10.1002/prp2.149] [PMID: 26171228]
[http://dx.doi.org/10.1056/NEJMp1106161] [PMID: 21830965]
[http://dx.doi.org/10.1200/JCO.2017.73.9250] [PMID: 28968167]
[http://dx.doi.org/10.1016/j.cllc.2017.06.013] [PMID: 28743421]
[http://dx.doi.org/10.1038/s41598-018-23321-6] [PMID: 29563526]
[http://dx.doi.org/10.1016/j.ijbiomac.2015.09.026] [PMID: 26391597]
[http://dx.doi.org/10.1016/j.febslet.2009.07.029] [PMID: 19622354]
[http://dx.doi.org/10.1186/1476-4598-10-12] [PMID: 21299897]
[http://dx.doi.org/10.1016/j.biotechadv.2014.04.004] [PMID: 24793420]
[http://dx.doi.org/10.1016/j.biopha.2017.10.119] [PMID: 29080464]
[http://dx.doi.org/10.1016/j.biopha.2016.11.098] [PMID: 27930973]
[http://dx.doi.org/10.1158/1078-0432.CCR-05-0171] [PMID: 16166455]
[http://dx.doi.org/10.1593/tlo.09193] [PMID: 19956394]
[PMID: 20332435]
[http://dx.doi.org/10.18632/oncotarget.6553] [PMID: 26672603]
[http://dx.doi.org/10.1159/000098655] [PMID: 17228149]
[http://dx.doi.org/10.1186/s13063-015-0641-1] [PMID: 25872567]
[http://dx.doi.org/10.3892/ol.2019.10204] [PMID: 31186739]
[http://dx.doi.org/10.1002/ijc.24593] [PMID: 19623659]
[http://dx.doi.org/10.3892/etm.2013.1297] [PMID: 24223665]
[http://dx.doi.org/10.1186/1471-2407-11-149] [PMID: 21510869]
[http://dx.doi.org/10.1038/srep26064] [PMID: 27263652]
[http://dx.doi.org/10.1155/2012/709739] [PMID: 22685460]
[http://dx.doi.org/10.2741/e798] [PMID: 28199187]
[http://dx.doi.org/10.5483/BMBRep.2015.48.8.216] [PMID: 25441423]
[http://dx.doi.org/10.21037/tcr.2016.11.04] [PMID: 30613476]
[http://dx.doi.org/10.1159/000441148] [PMID: 26771576]
[http://dx.doi.org/10.3892/ol.2017.6627] [PMID: 28927092]
[http://dx.doi.org/10.1111/jcpt.12703] [PMID: 29722036]
[http://dx.doi.org/10.1038/s41598-017-00812-6] [PMID: 28400554]
[http://dx.doi.org/10.3382/ps/pew069] [PMID: 26944958]
[http://dx.doi.org/10.1155/2014/561456] [PMID: 24949457]
[http://dx.doi.org/10.7897/2230-8407.087126]
[http://dx.doi.org/10.1016/j.phymed.2013.02.006] [PMID: 23537748]
[http://dx.doi.org/10.1039/C6MD00649C] [PMID: 30108820]
[http://dx.doi.org/10.22271/ortho.2016.v2.i4g.67]
[http://dx.doi.org/10.1186/s12906-017-2062-z] [PMID: 29316908]
[http://dx.doi.org/10.3892/mmr.2013.1661] [PMID: 24002213]
[http://dx.doi.org/10.1093/rheumatology/kei132] [PMID: 16249246]
[http://dx.doi.org/10.1016/j.joim.2018.08.003] [PMID: 30139656]
[http://dx.doi.org/10.3109/15376516.2011.603392] [PMID: 21859361]
[PMID: 25035531]
[http://dx.doi.org/10.1002/ptr.5025] [PMID: 23832433]
[http://dx.doi.org/10.1016/j.psyneuen.2011.04.012] [PMID: 21612876]
[http://dx.doi.org/10.1016/j.fct.2010.05.073] [PMID: 20561944]
[http://dx.doi.org/10.4103/0250-474X.44591] [PMID: 20046768]
[http://dx.doi.org/10.1002/ptr.5030] [PMID: 23873854]
[http://dx.doi.org/10.1590/S0102-695X2012005000117]
[http://dx.doi.org/10.5897/AJFS11.060]
[http://dx.doi.org/10.1002/pca.1129] [PMID: 19402187]
[http://dx.doi.org/10.1016/j.jpha.2013.10.002] [PMID: 29403896]
[http://dx.doi.org/10.1016/j.ijpharm.2015.04.067] [PMID: 25936626]
[http://dx.doi.org/10.1016/S1995-7645(14)60250-9] [PMID: 25312141]
[http://dx.doi.org/10.1016/j.toxrep.2014.12.017] [PMID: 28962370]
[http://dx.doi.org/10.1016/j.ejphar.2013.12.028] [PMID: 24384407]
[http://dx.doi.org/10.1016/j.jconrel.2013.08.302] [PMID: 24036260]
[http://dx.doi.org/10.1016/j.lfs.2013.12.200] [PMID: 24394958]
[http://dx.doi.org/10.1016/j.mrfmmm.2014.05.006] [PMID: 25847272]
[http://dx.doi.org/10.1016/j.ijbiomac.2013.04.031] [PMID: 23603073]
[http://dx.doi.org/10.1016/j.carbpol.2013.08.067] [PMID: 24274536]
[http://dx.doi.org/10.1016/j.ijporl.2013.11.024] [PMID: 24355767]
[http://dx.doi.org/10.1016/j.ejmech.2014.01.041] [PMID: 24531225]