Recent Advances in the Discovery and Development of Marine Natural Products with Cardiovascular Pharmacological Effects

Title:Recent Advances in the Discovery and Development of Marine Natural Products with Cardiovascular Pharmacological Effects

Volume: 18 Issue: 6

Author(s): Jie-Bin Zhou, Rong Luo, Ying-Lin Zheng and Ji-Yan Pang*

Affiliation:

• School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275,China

Keywords: Marine, natural products, discovery, cardiovascular, pharmacology, marine polysaccharide.

Abstract: Numerous studies have indicated that marine natural products are one of the most important sources of the lead compounds in drug discovery for their unique structures, various bioactivities and less side effects. In this review, the marine natural products with cardiovascular pharmacological effects reported after 2000 will be presented. Their structural types, relevant biological activities, origin of isolation and information of strain species will be discussed in detail. Finally, by describing our studies as an example, we also discuss the chances and challenges for translating marine-derived compounds into preclinical or clinical trials.

Cite this article as:

Zhou Jie-Bin , Luo Rong, Zheng Ying-Lin and Pang Ji-Yan *, Recent Advances in the Discovery and Development of Marine Natural Products with Cardiovascular Pharmacological Effects, Mini-Reviews in Medicinal Chemistry 2018; 18 (6) . https://dx.doi.org/10.2174/1389557517666170927112621