Abstract
Objective: This study focused to systematically extract, summarize and analyse the data on the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome.
Methods: The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct, CINAHL, Springer link, Web of Science from 2000-2018. English language articles and quantitative studies focusing on leptin resistance and quality of life were included. Random effect analysis was adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance and quality of life which included a total of 9 studies on both RCTs and Non-RCTs.
Results: The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance in metabolic syndrome when compared to comparison group (-5.94(-14.28, 2.41). Two clinical trials showed a significant effect with pooled data (5.52(2.14, 8.91). Meta-analysis of RCTs focusing on quality of life showed significant effect on mental component (4.89 (0.16, 9.62) of quality of life (2.36 (-3.67, 8.39) when compared to comparison group.
Conclusion: This meta-analysis suggested that lifestyle modification has a potential to improve leptin resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined studies are required to come to a stronger conclusion.
Keywords: Metabolic syndrome, lifestyle modification, physical activity promotion, leptin resistance, quality of life, metaanalysis.
[http://dx.doi.org/10.1002/cphy.c110062 ] [PMID: 23720280]
[http://dx.doi.org/10.1152/ajpendo.00469.2001 ] [PMID: 11832370]
[PMID: 9495630]
[http://dx.doi.org/10.1038/oby.2006.248 ] [PMID: 17189537]
[http://dx.doi.org/10.2337/diab.41.6.715 ] [PMID: 1587398]
[http://dx.doi.org/10.2337/diacare.14.3.173 ] [PMID: 2044434]
[http://dx.doi.org/10.1161/01.ATV.10.4.493 ] [PMID: 2196039]
[http://dx.doi.org/10.1038/nature05488 ] [PMID: 17167477]
[http://dx.doi.org/10.1038/nature05482 ] [PMID: 17167471]
[http://dx.doi.org/10.2337/db11-0425 ] [PMID: 21948998]
[http://dx.doi.org/10.1016/j.ijcard.2003.11.003 ] [PMID: 15458693]
[PMID: 27735144]
[http://dx.doi.org/10.1371/journal.pone.0192372 ] [PMID: 29584725]
[http://dx.doi.org/10.1155/2014/726861 ] [PMID: 24563869]
[http://dx.doi.org/10.2174/138161282004140213160930]
[http://dx.doi.org/10.1155/2015/534320 ] [PMID: 26064110]
[http://dx.doi.org/10.1242/dmm.001180 ] [PMID: 19407331]
[http://dx.doi.org/10.2147/DMSOTT.S13860]
[http://dx.doi.org/10.1016/0277-9536(95)00112-K ] [PMID: 8560308]
[http://dx.doi.org/10.1038/oby.2003.144 ] [PMID: 12972674]
[http://dx.doi.org/10.1590/S0034-89102012000100021 ] [PMID: 22249758]
[http://dx.doi.org/10.1136/jech.52.6.377 ] [PMID: 9764259]
[http://dx.doi.org/10.5935/abc.20160186]
[http://dx.doi.org/10.1177/2047487312445000.]
[http://dx.doi.org/10.1038/nutd.2016.35 ] [PMID: 28067891]
[http://dx.doi.org/10.1016/j.ijcard.2016.12.084 ] [PMID: 28040281]
[http://dx.doi.org/10.1016/j.metabol.2009.10.027] [PMID: 20045151]
[http://dx.doi.org/10.1186/1476-511X-9-148 ] [PMID: 21194421]
[http://dx.doi.org/10.1016/j.orcp.2012.10.005 ] [PMID: 24548583]
[http://dx.doi.org/10.1038/oby.2005.66]
[http://dx.doi.org/10.1038/oby.2008.251 ] [PMID: 18451775]
[http://dx.doi.org/10.1186/s12933-017-0528-4 ] [PMID: 28376896]