Review Article

Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells

Author(s): Conrad R.Y. Cruz and Catherine M. Bollard

Volume 18, Issue 3, 2017

Page: [271 - 280] Pages: 10

DOI: 10.2174/1389450117666160209143529

Price: $65

Abstract

The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T cell therapeutics with a focus on how the manufacturing strategies have been refined, and where the research is heading.

Keywords: Cell therapy, leukemia antigens, ex vivo expanded T cells.

Graphical Abstract


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