Peptides, Proteins and Peptide/Protein-Polymer Conjugates as Drug Delivery System

Title:Peptides, Proteins and Peptide/Protein-Polymer Conjugates as Drug Delivery System

Volume: 21 Issue: 11

Author(s): Biswajit Mukherjee, Swapna D. Karmakar, Chowdhury M. Hossain and Sanchari Bhattacharya

Affiliation:

Keywords: Conjugates, drug delivery, peptides, proteins, virus nanoparticles.

Abstract: In the last few decades, novel drug delivery strategies have been a big priority to the formulation scientists. Peptides and proteins have drawn a special attention for their wide scope in the area. Serum albumin, transferrin, recom- binant proteins, virus capsids etc. are used as carrier for drug and biomolecules. Conjugates of polymers with proteins have also shown strong potency in the field of drug delivery. Polyethylene glycol is one of the most successful polymers that has been used extensively to develop protein conjugated formulations. Besides, polyvinyl pyrrolidone, polylactic-co- glycolic acid, N-(2-hydroxypropyl) methacrylamide copolymer, polyglutamic acid have also been investigated. In this re- view, we will highlight on the most recent overview of various advantages, limitations and marketed products of proteins, peptides and protein/peptide-polymer conjugates as drug carriers, such products in clinical trials and their various uses in the field of modern drug delivery. Understanding the key features of these materials and the vigorous research in this field will develop new drug formulations that will combat various types of life-threatening diseases.

Cite this article as:

Mukherjee Biswajit, Karmakar D. Swapna, Hossain M. Chowdhury and Bhattacharya Sanchari, Peptides, Proteins and Peptide/Protein-Polymer Conjugates as Drug Delivery System, Protein & Peptide Letters 2014; 21 (11) . https://dx.doi.org/10.2174/0929866521666140804160907