Abstract
Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.
Keywords: Alamar blue assay, nucleophilic addition, tuberculosis.
Graphical Abstract
Infectious Disorders - Drug Targets
Title:Hydrazones as a Privileged Structural Linker in Antitubercular Agents: A Review
Volume: 15 Issue: 2
Author(s): Bijo Mathew, Jerad Suresh, Mohamed J. Ahsan, Githa E. Mathew, Dhasthakeer Usman, Puthucode N.S. Subramanyan, Kallivalappil F. Safna and Srinubabu Maddela
Affiliation:
Keywords: Alamar blue assay, nucleophilic addition, tuberculosis.
Abstract: Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.
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Mathew Bijo, Suresh Jerad, Ahsan J. Mohamed, Mathew E. Githa, Usman Dhasthakeer, Subramanyan N.S. Puthucode, Safna F. Kallivalappil and Maddela Srinubabu, Hydrazones as a Privileged Structural Linker in Antitubercular Agents: A Review, Infectious Disorders - Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1871526515666150724104411
DOI https://dx.doi.org/10.2174/1871526515666150724104411 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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