Abstract
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are two important lung and airways diseases which affect the lives of ~500 million people worldwide. Asthma is a heterogeneous disease that is broadly defined as a clinical syndrome characterized by altered lung function, mucus hypersecretion, peribronchial inflammation and hyperresponsiveness In contrast, the effect of inhalation of toxic particles and gases on the innate and adaptive inflammatory immune systems underlie the pathogenesis of COPD. In the last decade, knowledge concerning the pathophysiologic mechanisms underlying asthma and COPD has risen tremendously and current dogma suggests that the pathogenesis of both diseases is driven by the chronic inflammation present in the airways of these patients. Thus, understanding the mechanisms for the persistence of inflammation may lead to new therapeutic approaches. In this review, we provide an overview of the main signal transduction pathways implicated in asthma and COPD pathophysiology focusing on inflammasome signaling in various cells types which result in altered inflammatory mediator expression.
Keywords: Airways, COPD, asthma, inflammasome, NLRP3, caspase-1
Current Pharmaceutical Design
Title:Inflammasome Signaling in Pathogenesis of Lung Diseases
Volume: 18 Issue: 16
Author(s): Esmaeil Mortaz, Mohammad Reza Masjedi, Abdolamir Allameh and Ian M. Adcock
Affiliation:
Keywords: Airways, COPD, asthma, inflammasome, NLRP3, caspase-1
Abstract: Asthma and Chronic Obstructive Pulmonary Disease (COPD) are two important lung and airways diseases which affect the lives of ~500 million people worldwide. Asthma is a heterogeneous disease that is broadly defined as a clinical syndrome characterized by altered lung function, mucus hypersecretion, peribronchial inflammation and hyperresponsiveness In contrast, the effect of inhalation of toxic particles and gases on the innate and adaptive inflammatory immune systems underlie the pathogenesis of COPD. In the last decade, knowledge concerning the pathophysiologic mechanisms underlying asthma and COPD has risen tremendously and current dogma suggests that the pathogenesis of both diseases is driven by the chronic inflammation present in the airways of these patients. Thus, understanding the mechanisms for the persistence of inflammation may lead to new therapeutic approaches. In this review, we provide an overview of the main signal transduction pathways implicated in asthma and COPD pathophysiology focusing on inflammasome signaling in various cells types which result in altered inflammatory mediator expression.
Export Options
About this article
Cite this article as:
Mortaz Esmaeil, Reza Masjedi Mohammad, Allameh Abdolamir and M. Adcock Ian, Inflammasome Signaling in Pathogenesis of Lung Diseases, Current Pharmaceutical Design 2012; 18 (16) . https://dx.doi.org/10.2174/138161212800166077
DOI https://dx.doi.org/10.2174/138161212800166077 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Medical Management and Risk Reduction of the Cardiovascular Effects of Underwater Diving
Current Vascular Pharmacology Chemogenomic Investigation of AP-1 Transcriptional Regulation of LTC4 Synthase Expression
Letters in Drug Design & Discovery S-Nitrosothiols as Nitric Oxide-Donors: Chemistry, Biology and Possible Future Therapeutic Applications
Current Medicinal Chemistry Anti-inflammatory Lipid Mediators Derived from ω-6 and ω-3 Polyunsaturated Fatty Acids as a Treatment Option for IBD
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A2A Adenosine Receptor Agonists and their Potential Therapeutic Applications. An Update
Current Medicinal Chemistry Regulation of Expression and Function of IDO in Human Dendritic Cells
Current Medicinal Chemistry Human Beta-Defensin-3: A Promising Antimicrobial Peptide
Mini-Reviews in Medicinal Chemistry Advances in Whole Genome Sequencing Technology
Current Pharmaceutical Biotechnology Electronic Monitoring Devices as an Intervention in Asthma: The Story So Far
Current Respiratory Medicine Reviews Signal transduction in Acute Myeloid Leukemia – Implications for Novel Therapeutic Concepts.
Current Cancer Drug Targets Molecular Mechanisms Underlying St. Johns Wort Drug Interactions
Current Drug Metabolism Use of Antibiotics in Bronchiectasis
Reviews on Recent Clinical Trials Nutritional Aspects Relating to the Developmental Origins of Health and Disease
Current Women`s Health Reviews Recent Insights into COVID-19 in Children and Clinical Recommendations
Current Pediatric Reviews Purine Derivatives as Ligands for A3 Adenosine Receptors
Current Topics in Medicinal Chemistry Is There a Place for Nebulized Magnesium Sulfate in the Treatment of Acute Asthma? A Systematic Review
Current Drug Therapy The Role of β2-Adrenergic Receptors in Inflammation and Allergy
Current Drug Targets - Inflammation & Allergy Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
Current Drug Targets Immunomodulatory Effect of Cytokines in the Differentiation of Mesenchymal Stem Cells: A Review
Current Stem Cell Research & Therapy Withdrawal Notice: Vilsmeier-Haack Cyclisation as A Facile Synthetic Route to Thieno [2,3-b] quinolines (Part I)
Letters in Organic Chemistry