Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector

Rosamund      Chapman; Gerald      Chege; Enid      Shephard; Helen      Stutz; Anna-Lise      Williamson

doi:10.2174/157016210791208686

Abstract

HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine. Numerous features make BCG an attractive vehicle to deliver HIV antigens. It has a good safety profile, elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable, a necessary consideration for developing countries. In this review we discuss the numerous factors that influence generation of a genetically stable recombinant BCG vaccine for HIV.

Keywords: Recombinant BCG, Mycobacterium bovis BCG, HIV, vaccine vector

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