Piperine and Derivatives: Trends in Structure-Activity Relationships

Title:Piperine and Derivatives: Trends in Structure-Activity Relationships

Volume: 15 Issue: 17

Author(s): Inder Pal Singh and Alka Choudhary

Affiliation:

Keywords: Anti-cancer, Anti-leishmanial, Anti-trypanosomal, Piperine, Piper nigrum, Structure-activity relationship.

Abstract: Piperine is the main constituent of pepper, a commonly used kitchen spice and has been reported to possess various pharmacological activities. The structural features, an aromatic ring with a methylenedioxy bridge, a conjugated dienone system and a piperidine ring constituting an amide bond, possessed by the molecule have been considered important for the molecule to exhibit an array of bioactivities. Several modifications of above structural units have affected the biological properties of piperine, either enhancing or in some cases completely abolishing the activity. The present review emphasizes on the synthetic aspects of piperine along with the structure-activity relationships of its derivatives so as to rationalize the discovery of newer piperine based molecules.

Cite this article as:

Singh Pal Inder and Choudhary Alka, Piperine and Derivatives: Trends in Structure-Activity Relationships, Current Topics in Medicinal Chemistry 2015; 15 (17) . https://dx.doi.org/10.2174/1568026615666150427123213