Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents

Title:Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents

Volume: 22 Issue: 30

Author(s): Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez, Dieudonne Njamen and Colin Clyne Hudson

Affiliation:

Keywords: Breast cancer, chemopreventive agents, chemotherapeutic agents, flavonoids.

Abstract: Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.

Cite this article as:

Magne Nde Chantal Beatrice, Zingue Stephane, Winter Evelyn, Beatriz Creczynski-Pasa Tania, Michel Thomas, Fernandez Xavier, Njamen Dieudonne and Clyne Hudson Colin, Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/0929867322666150729115321