Biological Therapies in Osteoarthritis

Title:Biological Therapies in Osteoarthritis

Volume: 21 Issue: 17

Author(s): Claire Y.J. Wenham, Michael McDermott and Philip G. Conaghan

Affiliation:

Keywords: Osteoarthritis, tumour necrosis factor, interleukin-1, growth factors, calcitonin gene related peptide, biologics.

Abstract: Given the paucity of effective therapies and the increasing prevalence of osteoarthritis (OA) with ageing and overweight populations, new therapies for this painful, life-impairing condition are desperately needed, for both symptom relief and structural modification. With a growing understanding that OA involves multiple tissue pathologies including inflammation, many more therapeutic targets have been identified. This review will provide a current overview on the role of biologics in OA, including anti-tumour necrosis factor agents, growth factors and interleukin-1 antagonists.

Cite this article as:

Wenham Y.J. Claire, McDermott Michael and Conaghan G. Philip, Biological Therapies in Osteoarthritis, Current Pharmaceutical Design 2015; 21 (17) . https://dx.doi.org/10.2174/1381612821666150310144940