Abstract
We provide a brief review of the significance of platelets, mitochondria, vitamin D, serotonin, and the gut microbiome in COVID-19. We hypothesize that hyperactive platelets and mitochondrial dysfunction, as well as low vitamin D level, gut dysbiosis, and increased serum serotonin produced by enterochromaffin cells, may all represent important aspects in the pathophysiology of COVID-19.
Keywords: Platelets, mitochondria, vitamin D, serotonin, gut-brain axis, COVID-19, SARS-CoV-2.
Current Medicinal Chemistry
Title:COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota
Volume: 28 Issue: 37
Author(s): István Bókkon*, Gábor Kapócs, András Vucskits, Attila Erdöfi-Szabó, Jan Vagedes , Felix Scholkmann and Henrik Szöke
Affiliation:
- Vision Research Institute, Neuroscience and Consciousness Research Department, Lowell, MA,United States
Keywords: Platelets, mitochondria, vitamin D, serotonin, gut-brain axis, COVID-19, SARS-CoV-2.
Abstract: We provide a brief review of the significance of platelets, mitochondria, vitamin D, serotonin, and the gut microbiome in COVID-19. We hypothesize that hyperactive platelets and mitochondrial dysfunction, as well as low vitamin D level, gut dysbiosis, and increased serum serotonin produced by enterochromaffin cells, may all represent important aspects in the pathophysiology of COVID-19.
Export Options
About this article
Cite this article as:
Bókkon István*, Kapócs Gábor , Vucskits András , Erdöfi-Szabó Attila , Vagedes Jan , Scholkmann Felix and Szöke Henrik , COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota, Current Medicinal Chemistry 2021; 28 (37) . https://dx.doi.org/10.2174/0929867328666210526100147
DOI https://dx.doi.org/10.2174/0929867328666210526100147 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Medicinal Chemistry Approaches for Glucokinase Activation to Treat Type 2 Diabetes
Current Medicinal Chemistry Primary and Secondary Hypertriglyceridaemia
Current Drug Targets Vascular Endothelial Growth Factor Receptors [VEGFR] as Target in Breast Cancer Treatment: Current Status in Preclinical and Clinical Studies and Future Directions
Current Topics in Medicinal Chemistry Ovarian Tissue Vitrification: Modalities, Challenges and Potentials
Current Women`s Health Reviews Gold Nanoparticles as an HIV Entry Inhibitor
Current HIV Research Inflammaging of Female Reproductive System: A Molecular Landscape
Current Aging Science The Leptin System: A Potential Target for Sepsis Induced Immune Suppression
Endocrine, Metabolic & Immune Disorders - Drug Targets Clinical Trajectories and Biological Features of Primary Progressive Aphasia (PPA)
Current Alzheimer Research Therapeutic Targets in the Ubiquitin-proteasome System for Alzheimer's Disease
Current Enzyme Inhibition Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?
CNS & Neurological Disorders - Drug Targets The Dual Role of Tumor Necrosis Factor (TNF) in Cancer Biology
Current Medicinal Chemistry Vaccination in Pregnancy
Current Pharmaceutical Biotechnology Metal Complexes, their Cellular Targets and Potential for Cancer Therapy
Current Pharmaceutical Design Anticancer Drugs Designed by Mother Nature: Ancient Drugs but Modern Targets
Current Pharmaceutical Design A Review on GABA/Glutamate Pathway for Therapeutic Intervention of ASD and ADHD
Current Medicinal Chemistry Toward The Rational Design of Cell Fate Modifiers Notch Signaling as a Target for Novel Biopharmaceuticals
Current Pharmaceutical Biotechnology From CHD Susceptibility Genes to New Therapeutics
Current Pharmacogenomics Anesthesia and Postoperative Cognitive Dysfunction (POCD)
Central Nervous System Agents in Medicinal Chemistry The-N-End Rule: The Beginning Determines the End
Protein & Peptide Letters Perioperative Considerations in Diabetic Patients
Current Diabetes Reviews