Efficient and Environmentally Benign Diversity Oriented Synthesis of 2, 3- dihydroquinazolin-4(1H)-ones Using GAAS As a Bio-based Green Solvent

Title:Efficient and Environmentally Benign Diversity Oriented Synthesis of 2, 3- dihydroquinazolin-4(1H)-ones Using GAAS As a Bio-based Green Solvent

Volume: 2 Issue: 2

Author(s): Sarita Khandelwal, Anshu Rajawat, Yogesh K. Tailor and Mahendra Kumar

Affiliation:

Keywords: 2, 3-dihydroquinazolin-4(1H)-ones, domino protocol, gluconic acid aqueous solution (GAAS 50%, wt %), multicomponent reaction.

Abstract: An efficient and environmentally benign domino protocol has been presented for the synthesis of structurally diverse 2,3-dihydroquinazolin-4(1H)-one derivatives involving three-component reaction of isatoic anhydride, substituted anilines and aromatic aldehydes in the presence of gluconic acid aqueous solution (50%, wt %). The present protocol offers several advantages such as operational simplicity with easy workup, shorter reaction times, and excellent yields with superior atom economy and environmentally benign reaction conditions with the use of cost-effective, recyclable, non-toxic and bio-degradable GAAS (50%, wt %) as catalyst/solvent.

Cite this article as:

Khandelwal Sarita, Rajawat Anshu, Tailor K. Yogesh and Kumar Mahendra, Efficient and Environmentally Benign Diversity Oriented Synthesis of 2, 3- dihydroquinazolin-4(1H)-ones Using GAAS As a Bio-based Green Solvent, Current Green Chemistry 2015; 2 (2) . https://dx.doi.org/10.2174/2213346102666150121224434

DOI https://dx.doi.org/10.2174/2213346102666150121224434	Print ISSN 2213-3461
Publisher Name Bentham Science Publisher	Online ISSN 2213-347X