Generic placeholder image

Current Psychopharmacology

Editor-in-Chief

ISSN (Print): 2211-5560
ISSN (Online): 2211-5579

Changes of Gene Expression in the Developing Brain by Acute Ethanol Exposure

Author(s): Nayoung Kim, Sang Soo Kang and Wan Sung Choi

Volume 1, Issue 4, 2012

Page: [344 - 352] Pages: 9

DOI: 10.2174/2211556011201040344

Price: $65

Abstract

Ethanol is one of the most common teratogens, causing a broad range of physiological, neuronal and behavioral problems, named as fetal alcohol spectrum disorder (FASD). Expression of various molecules involved in apoptosis, signaling pathways, and innate immune system, has been shown to change upon acute ethanol exposure. Gene expression profiling has been attempted by several groups, but comprehensive understanding is required, considering different experimental protocols used by each group. In this review, we summarize previously published reports of transcriptome analyses and our own previously unpublished results of cDNA microarray, according to developmental stages of brain and discuss about what we have learned from the results.

Keywords: Transcriptome analysis, fetal alcohol spectrum disorder, fetal alcohol syndrome, Acute Ethanol Exposure, cDNA microarray, FASD, synaptogenesis, TNFRSF1A, PI3K signaling pathways, glycolysis , neurodegeneration, neuroinflammation, brain damage, dysmorphism, glandular tissues


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy