Virtual Screening Against Obesity

P.      Markt; S.      Herdlinger; D.      Schuster

doi:10.2174/092986711795656162

Abstract

The development of novel drugs against obesity is one of the top priorities of worldwide drug research. In recent years, it has been facilitated by the application of virtual screening methods. In this review, we give a short introduction into obesity-related protein targets and computer-aided drug design techniques. Furthermore, we highlight the most successful virtual screening studies, outline their results, and provide suggestions for future anti-obesity drug development.

Keywords: Anti-obesity drug, computer-aided drug design, ligand-based, molecular mechanisms, obesity, obesity targets, structure-based, virtual screening, screening studies