Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives

Title:Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives

Volume: 15 Issue: 3

Author(s): Enise Ece Gurdal, Ebru Buclulgan, Irem Durmaz, Rengul Cetin-Atalay and Mine Yarim

Affiliation:

Keywords: Anticancer, apoptosis, benzothiazole, cytotoxicity, piperazine, sulphorhodamine B.

Abstract: Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI₅₀ values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Aroyl substituted compounds 1h and 1j were found to be the most active derivatives. In addition, further investigation of compounds 1h and 1j by Hoechst staining and FACS revealed that these compounds cause apoptosis by cell cycle arrest at subG₁ phase.

Cite this article as:

Gurdal Ece Enise, Buclulgan Ebru, Durmaz Irem, Cetin-Atalay Rengul and Yarim Mine, Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (3) . https://dx.doi.org/10.2174/1871520615666141216151101