Combinatorial Protein Biochemistry for Therapeutics and Proteomics

David      Lowe; Lutz      Jermutus

doi:10.2174/1389201043489585

Abstract

This paper reviews progress towards the customised generation of proteins for applications as therapeutics, diagnostics and in proteomics. It particularly focuses on combinatorial approaches where proteins with pre-defined biochemical and biophysical characteristics are selected from large variant libraries.

Keywords: protein therapeutic, protein engineering, display, directed evolution, alternative frameworks

« Previous Next »