Abstract
Liposomes are widely used as drug delivery systems and several liposome-based nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have been decorated onto nanoparticulated vesicle such as liposomes to further improve the intracellular delivery efficiency. However, the poor selectivity of CPPs hindered their application, especially in the in vivo application. To resolve this issue, several strategies have been developed, including shielding and environment-triggered deshielding of CPPs as well as designing of environment-responsive CPPs and specific- targeting CPPs and last but not least, combination strategy. In this review, the abovementioned strategies were discussed.
Keywords: Cell penetrating peptides, liposomes, intelligent.
Current Pharmaceutical Biotechnology
Title:Cell-penetrating Peptide-based Intelligent Liposomal Systems for Enhanced Drug Delivery
Volume: 15 Issue: 3
Author(s): Huile Gao, Qianyu Zhang, Zhiqiang Yu and Qin He
Affiliation:
Keywords: Cell penetrating peptides, liposomes, intelligent.
Abstract: Liposomes are widely used as drug delivery systems and several liposome-based nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have been decorated onto nanoparticulated vesicle such as liposomes to further improve the intracellular delivery efficiency. However, the poor selectivity of CPPs hindered their application, especially in the in vivo application. To resolve this issue, several strategies have been developed, including shielding and environment-triggered deshielding of CPPs as well as designing of environment-responsive CPPs and specific- targeting CPPs and last but not least, combination strategy. In this review, the abovementioned strategies were discussed.
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Cite this article as:
Gao Huile, Zhang Qianyu, Yu Zhiqiang and He Qin, Cell-penetrating Peptide-based Intelligent Liposomal Systems for Enhanced Drug Delivery, Current Pharmaceutical Biotechnology 2014; 15 (3) . https://dx.doi.org/10.2174/1389201015666140617092552
DOI https://dx.doi.org/10.2174/1389201015666140617092552 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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