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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System

Author(s): Ting Kang, Xiaoling Gao and Jun Chen

Volume 15, Issue 3, 2014

Page: [220 - 230] Pages: 11

DOI: 10.2174/1389201015666140617094952

Price: $65

Abstract

The existence of blood-brain barrier (BBB) represents the most formidable challenge for drug delivery to the central nervous system (CNS). Modern breakthrough in biology offers multiple choices for overcoming this barrier but yields modest outcomes for clinical application due to various problems such as safety concerns, insufficient delivery efficiency and poor penetration. Cell penetrating peptides (CPPs) possessing powerful transmembrane capacity have been shown to be effective transport vectors for bioactive molecules and an attractive alternative to traditional active targeting approaches. However, the non-specificity of CPPs has hindered them from targeting a desired site of action. Promisingly, design of novel CPP-mediated nanoparticulate delivery systems with specific targeting property may extricate CPPs from the dilemma. In this review, both the traditional and novel applications of CPPs-based strategies for CNS drug delivery will be discussed.

Keywords: Blood-brain barrier, cell penetrating peptides, central nervous system, drug delivery.


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