Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives

Title:Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives

Volume: 11 Issue: 8

Author(s): Abdulrahman I. Almansour, Venu Sanjeevi Lakshmipathi, Elumalai Manogaran, Mohamed Ashraf Ali, Farzana Beevi, Tan Soo Choon, Ang Chee Wei, Raju Suresh Kumar and Mohammad Asad

Affiliation:

Keywords: [3+2]-cycloaddition, Antimycobacterial activity, Azomethine ylide, Dispiroheterocycle, Intermolecular.

Abstract: A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H₃₇Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1µM. Compound (4d) was found to be the most active with MIC of 0.231 µM and 4.372 µM respectively.

Cite this article as:

Almansour I. Abdulrahman, Lakshmipathi Sanjeevi Venu, Manogaran Elumalai, Ali Ashraf Mohamed, Beevi Farzana, Choon Soo Tan, Wei Chee Ang, Kumar Suresh Raju and Asad Mohammad, Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives, Letters in Drug Design & Discovery 2014; 11 (8) . https://dx.doi.org/10.2174/1570180811666140506204239

DOI https://dx.doi.org/10.2174/1570180811666140506204239	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X