Design, Synthesis and Biological Evaluation of Some Oxadiazole Derivatives as Novel Amide-Based Inhibitors of Soluble Epoxide Hydrolase

Title:Design, Synthesis and Biological Evaluation of Some Oxadiazole Derivatives as Novel Amide-Based Inhibitors of Soluble Epoxide Hydrolase

Volume: 11 Issue: 6

Author(s): Elham Rezaee Zavareh, Mahdi Hedayati, Laleh Hoghooghi Rad, Azin Kiani, Soraya Shahhosseini, Mehrdad Faizi and Sayyed Abbas Tabatabai

Affiliation:

Keywords: Biological evaluation, Docking, Oxadiazole, Physical properties, Soluble epoxide hydrolase, Synthesis.

Abstract: Soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators which are involved in the regulation of blood pressure and inflammation. Although the most reported potent sEH inhibitors are urea derivatives, these compounds have limited pharmacokinetic profile. In order to improve physicochemical properties, besides having favorable potency, amide non-urea derivatives with oxadiazole ring as a novel secondary pharmacophore against sEH enzyme were developed. Most of the novel compounds with appropriate physical properties, had comparable in vitro sEH inhibitory activity to 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA), a potent urea-based sEH inhibitor. The IC₅₀ value of the most potent compound (15c) was 0.43 nM.

Cite this article as:

Zavareh Rezaee Elham, Hedayati Mahdi, Rad Hoghooghi Laleh, Kiani Azin, Shahhosseini Soraya, Faizi Mehrdad and Tabatabai Abbas Sayyed, Design, Synthesis and Biological Evaluation of Some Oxadiazole Derivatives as Novel Amide-Based Inhibitors of Soluble Epoxide Hydrolase, Letters in Drug Design & Discovery 2014; 11 (6) . https://dx.doi.org/10.2174/1570180811666140220005530

DOI https://dx.doi.org/10.2174/1570180811666140220005530	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X