A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane

Title:A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane

Volume: 11 Issue: 6

Author(s): Yinjiu Huang, Gang Liu, Xiaomei Hu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang and Xuehui Long

Affiliation:

Keywords: 1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.

Abstract: The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity which suggests that compound LG003 is a potential antitumor agent.

Cite this article as:

Huang Yinjiu, Liu Gang, Hu Xiaomei, Liu Hao, Hu Jianguo, Feng Zhenzhong, Tang Bi, Qian Jun, Wang Qiyi and Long Xuehui, A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane, Letters in Drug Design & Discovery 2014; 11 (6) . https://dx.doi.org/10.2174/1570180811666140214204858