Abstract
The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.
Keywords: Reactive oxygen species, oxidative stress, cell signaling, kinases, phosphatases, transcription factors, urokinase plasminogen activator, Arachidonic acid, tumorigenesis, H2O2
Current Pharmaceutical Design
Title: New Insights into Redox-Modulated Cell Signaling
Volume: 17 Issue: 36
Author(s): Gabriella Leonarduzzi, Barbara Sottero, Gabriella Gabriella Testa, Fiorella Biasi and Giuseppe Poli
Affiliation:
Keywords: Reactive oxygen species, oxidative stress, cell signaling, kinases, phosphatases, transcription factors, urokinase plasminogen activator, Arachidonic acid, tumorigenesis, H2O2
Abstract: The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.
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Cite this article as:
Leonarduzzi Gabriella, Sottero Barbara, Gabriella Testa Gabriella, Biasi Fiorella and Poli Giuseppe, New Insights into Redox-Modulated Cell Signaling, Current Pharmaceutical Design 2011; 17 (36) . https://dx.doi.org/10.2174/138161211798764906
DOI https://dx.doi.org/10.2174/138161211798764906 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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