Metal-N-Heterocyclic Carbene Complexes as Anti-Tumor Agents

Title:Metal-N-Heterocyclic Carbene Complexes as Anti-Tumor Agents

Volume: 21 Issue: 10

Author(s): Chunqi Hu, Xin Li, Wei Wang, Ruoyu Zhang and Liping Deng

Affiliation:

Keywords: NHCs, NHC-metal complexes, anti-tumor, biological evaluation.

Abstract: It has been a long story of the development of anticancer metallopharmaceuticals since the identification of cisplatin. Advances in metallodrugs discovery during the past 40 years have made it an ever-growing area of research in medicinal inorganic chemistry. Meanwhile, the emerging of N-heterocyclic carbene (NHC) chemistry has stimulated the newly burgeoning interests in the biomedical applications of metal-NHC complexes. This review will detail what have been achieved hitherto in the research of metal-NHC complexes as potential anti-tumor agents coupled with gold, silver, copper, platinum and palladium. Their mechanism of action will also be discussed. All the results obtained indicate that this promising approach is worthy of more focuses and further studies.

Cite this article as:

Hu Chunqi, Li Xin, Wang Wei, Zhang Ruoyu and Deng Liping, Metal-N-Heterocyclic Carbene Complexes as Anti-Tumor Agents, Current Medicinal Chemistry 2014; 21 (10) . https://dx.doi.org/10.2174/0929867321666131217161849